Patents by Inventor Daniel Coughlin

Daniel Coughlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
    Patent number: 8293739
    Abstract: The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. More specifically, the invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy) phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: October 23, 2012
    Assignee: Kinex Pharmaceuticals, LLC
    Inventors: David G. Hangauer, Jr., Daniel Coughlin, Jonathan Gale, Jeremy A. Cody, Debasis Patra, Grant J. Palmer, Paul K. Isbester, Jonathon Salsbury
  • Benzisoxazole piperidine compounds and methods of use thereof
    Patent number: 8129410
    Abstract: The invention includes benzisoxazole piperidine compositions and methods of using them for modulating sleep.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: March 6, 2012
    Assignee: Hypnion, Inc.
    Inventors: Daniel Coughlin, James F. White, Kazumi Shiosaki, David G. Hangauer, Michael Solomon, Dale M. Edgar
  • Benzisoxazole piperazine compounds and methods of use thereof
    Patent number: 8088778
    Abstract: The invention includes benzisoxazole piperazine compositions and methods of using them for modulating sleep.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: January 3, 2012
    Assignee: Hypnion, Inc.
    Inventors: Daniel Coughlin, James F. White, Kazumi Shiosaki, David G. Hangauer, Michael Solomon, Dale M. Edgar
  • Process for the Preparation of Compositions for Modulating a Kinase Cascade and Methods of Use Thereof
    Publication number: 20110201611
    Abstract: The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. More specifically, the invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention.
    Type: Application
    Filed: April 26, 2011
    Publication date: August 18, 2011
    Applicant: Kinex Pharmaceuticals, LLC
    Inventors: David G. Hangauer, JR., Daniel Coughlin, Jonathan Gale, Jeremy A. Cody, Debasis Patra, Grant J. Palmer, Paul K. Isbester, Jonathon Salsbury
  • Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
    Patent number: 7939529
    Abstract: The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. More specifically, the invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: May 10, 2011
    Assignee: Kinex Pharmaceuticals, LLC
    Inventors: David G. Hangauer, Jr., Daniel Coughlin, Jonathan Gale, Jeremy A. Cody, Debasis Patra, Grant J. Palmer, Paul K. Isbester, Jonathon Salsbury
  • Composition and methods for modulating a kinase cascade
    Patent number: 7851470
    Abstract: The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: December 14, 2010
    Assignee: Kinex Pharmaceuticals, LLC
    Inventors: David G. Hangauer, Jr., Daniel Coughlin, Jonathan Gale, Jeremy A. Cody, Debasis Patra
  • COMPOSITIONS OF CHOLINESTERASE INHIBITORS
    Publication number: 20100256229
    Abstract: The present invention is directed to compositions, methods of use, and processes for the synthesis related to 3-((S)-1-(dimethylamino)ethyl)phenyl methyl-((R)-1-phenylpropan-2 yl)carbamate, and its pharmaceutically acceptable salt forms, including the hydrogen fumarate salt. The present invention also relates to a novel form polymorph of 3-((S)-1-(dimethylamino)ethyl)phenylmethyl-((R)-1-phenylpropan-2 yl)carbamate, characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well a unique crystalline structure.
    Type: Application
    Filed: April 2, 2010
    Publication date: October 7, 2010
    Applicant: Colucid Pharmaceuticals, Inc.
    Inventors: Shoucheng Du, Marc W. Andersen, Daniel Coughlin, Alexander Kolchinski
  • BENZISOXAZOLE PIPERAZINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20090163514
    Abstract: The invention includes benzisoxazole piperazine compositions and methods of using them for modulating sleep.
    Type: Application
    Filed: February 11, 2009
    Publication date: June 25, 2009
    Inventors: Daniel Coughlin, James F. White, Kazumi Shiosaki, David G. Hangauer, Michael Solomon, Dale M. Edgar
  • Benzisoxazole piperazine compounds and methods of use thereof
    Patent number: 7494998
    Abstract: The invention includes benzisoxazole piperazine compositions and methods of using them for modulating sleep.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: February 24, 2009
    Assignee: Hypnion, Inc.
    Inventors: Daniel Coughlin, James F. White, Kazumi Shiosaki, David G. Hangauer, Michael Solomon, Dale M. Edgar
  • Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
    Publication number: 20080287436
    Abstract: The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. More specifically, the invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention.
    Type: Application
    Filed: May 19, 2008
    Publication date: November 20, 2008
    Inventors: David G. Hangauer, JR., Daniel Coughlin, Jeremy A. Cody, Jonathan Gale
  • Composition and methods for modulating a kinase cascade
    Publication number: 20080221102
    Abstract: The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
    Type: Application
    Filed: December 28, 2007
    Publication date: September 11, 2008
    Inventors: David G. Hangauer, Daniel Coughlin, Jeremy A. Cody, Jonathan Gale
  • Benzisoxazole Piperidine Compounds and Methods of Use Thereof
    Publication number: 20080214539
    Abstract: The invention includes benzisoxazole piperidine compositions and methods of using them for modulating sleep.
    Type: Application
    Filed: April 26, 2006
    Publication date: September 4, 2008
    Inventors: Daniel Coughlin, James F. White, Kazumi Shiosaki, David G. Hangauer, Michael Solomon, Dale M. Edgar
  • Benzisoxazole piperazine compounds and methods of use thereof
    Publication number: 20070004752
    Abstract: The invention includes benzisoxazole piperazine compositions and methods of using them for modulating sleep.
    Type: Application
    Filed: April 26, 2006
    Publication date: January 4, 2007
    Inventors: Daniel Coughlin, James White, Kazumi Shiosaki, David Hangauer, Michael Solomon, Dale Edgar
  • Beta-amino-alpha-cyanoacrylates and their use as herbicides
    Publication number: 20050054536
    Abstract: ?-Amino-?-Cyanoacrylates of formula I where the variables have the following meanings: R1 is n-alkyl, n-alkenyl or alkoxyalkyl; R2,R3 are alkyl, which may be partially or fully halogenated and/or may carry a substituent from the group consisting of cyano, alkoxy, haloalkoxy, alkylthio, haloalkylthio, C1-C6-alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl and haloalkylsulfonyl, are alkenyl or alkynyl; or R2 and R3 together with the carbon atom to which they are attached form a cycloalkyl ring in which one or two nonadjacent CH2 groups may be replaced by oxygen or sulfur, and where the cycloalkyl ring may be substituted by halogen or alkyl; R4 is hydrogen, halogen, cyano or alkyl, where the substituents R2, R3 and R4 or two of the radicals R2, R3 and R4 are not simultaneously methyl, and their agriculturally useful salts, processes and intermediates for their preparation; and the use of these compounds or of compositions comprising these compounds for controlling undesirable plants are described.
    Type: Application
    Filed: December 17, 2002
    Publication date: March 10, 2005
    Inventors: Albert Everson, Daniel Coughlin, Michael Guaciaro, Linda Fleming, Lester Maravetz, John Huppatz