Patents by Inventor Daniel D Sohn

Daniel D Sohn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tartrate salts of (R) -3-N,N- dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1- benzopyran-5-carboxamide
    Patent number: 6858645
    Abstract: A new salt (R)-3-N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrogen tartrate, particularly the (2R,3R)-tartrate thereof, most particularly the (R)-3-N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrogen (2R,3R)-tartrate monohydrate, processes for the manufacture of said tartrate salt, the use of the salt in medicine, the use of the tartrate salt in the manufacture of pharmaceutical formulations, and a method for the treatment of CNS disorders by administration of the tartrate salt to a host in need of such treatment.
    Type: Grant
    Filed: May 15, 1998
    Date of Patent: February 22, 2005
    Assignee: AstraZeneca AB
    Inventors: Hakan Nyqvist, Daniel D Sohn
  • TARTRATE SALTS OF (R) -3-N,N- DICYCLOBUTYLAMINO-8-FLUORO-3,4-DIHYDRO-2H-1- BENZOPYRAN-5-CARBOXAMIDE
    Publication number: 20030109576
    Abstract: A new salt (R)-3-N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrogen tartrate, particularly the (2R,3R)-tartrate thereof, most particularly the (R)-3-N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrogen (2R,3R)-tartrate monohydrate, processes for the manufacture of said tartrate salt, the use of the salt in medicine, the use of the tartrate salt in the manufacture of pharmaceutical formulations, and a method for the treatment of CNS disorders by administration of the tartrate salt to a host in need of such treatment.
    Type: Application
    Filed: June 8, 1998
    Publication date: June 12, 2003
    Inventors: HAKAN NYQVIST, DANIEL D SOHN
  • Process for the manufacture of 3-N-N-dicyclobutylamino-8-fluoro-3, 4-dihydro-2H-1-benzopyran-5-carboxamide
    Patent number: 6197978
    Abstract: A process for the manufacture of the racemic compound of the formula (I), its R-enantiomer (formula R-(I)) and its S-enantiomer (formula S-(I)), and pharmaceutically acceptable salts and/or solvates thereof, as well as new intermediates obtained and used in the process.
    Type: Grant
    Filed: May 6, 1998
    Date of Patent: March 6, 2001
    Assignee: Astra Aktiebolag
    Inventors: Sverker Hanson, Lars Johansson, Daniel D. Sohn
  • (R)-5-carbamoyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzo pyrans
    Patent number: 5616610
    Abstract: Compounds of the general formula ##STR1## wherein R.sub.1 is n-propyl or cyclobutyl;R.sub.2 is isopropyl, tertiary butyl, cyclobutyl, cyclopentyl or cyclohexyl;R.sub.3 is hydrogen;R.sub.4 is hydrogen or methyl;as (R)-enantiomer in the form of free base or pharmaceutically acceptable salts thereof, process for their preparation, pharmaceutical composition, use of and method of treatment of disorders in CNS.
    Type: Grant
    Filed: January 4, 1995
    Date of Patent: April 1, 1997
    Assignee: Astra Aktiebolag
    Inventors: John L. Evenden, Eva M. Hammarberg, Hans S. Hansson, Sven E. Hellberg, Lars G. Johansson, Johan R. M. Lundkvist, Svante B. Ross, Daniel D. Sohn, Seth O. Thorberg
  • 5-substituted pyrimidine nucleosides and nucleotides
    Patent number: 5576429
    Abstract: The present invention is directed to compounds of formula (I), ##STR1## wherein R.sup.1 is OH, NH.sub.2 ; R.sup.2 is a heteroaromatic or aromatic substituent; R.sup.3 is H, OH, F, OCH.sub.3 ; R.sup.4 is H, F, OH or an ether or ester residue thereof, OCH.sub.3, CN, C.dbd.CH, N.sub.3 ; R.sup.5 is OH or an ether or ester residue thereof including mono, di- and triphosphate esters (.alpha.), wherein n is 0 or 1 and M is hydrogen or a pharmaceutically acceptable counterion such as sodium, potassium, ammonium or alkylammonium; and pharmaceutically acceptable salts thereof; and pharmaceutical compositions comprising said compounds can be used for therapeutic treatment of virus infections.
    Type: Grant
    Filed: February 28, 1995
    Date of Patent: November 19, 1996
    Assignee: Medivir AB
    Inventors: Karl N. G. Johansson, Hans C. G. Malmberg, Rolf Noreen, S. Christer Sahlberg, Daniel D. Sohn, Sal o Gronowitz
  • Chroman derivatives and a method of treating 5-HT mediated disorders
    Patent number: 5500425
    Abstract: Compounds of the formula I ##STR1## processes for their preparation, pharmaceutical preparations, use of and method of treatment of disorders in CNS by using compounds of formula I.
    Type: Grant
    Filed: September 9, 1994
    Date of Patent: March 19, 1996
    Assignee: Aktiebolaget Astra
    Inventors: Lars-Gunnar Larsson, Lucy A. Renyl, Svante B. Ross, Daniel D. Sohn, Seth-Olov Thorberg
  • Substituted dihydrobenzopyrans
    Patent number: 4952705
    Abstract: The invention relates to compounds of the formula: ##STR1## which are useful as leukotriene D.sub.4 (LTD.sub.4) inhibitors and therefore useful in the treatment of allergies and inflammatory conditions.
    Type: Grant
    Filed: February 12, 1987
    Date of Patent: August 28, 1990
    Assignee: G. D. Searle & Co.
    Inventors: Masateru Miyano, Robert L. Shone, Daniel D. Sohn
  • Use of substituted dihydrobenzopyrans for allergy and inflammation
    Patent number: 4888356
    Abstract: The invention relates to compounds of the formula: ##STR1## which are useful as leukotriene D.sub.4 (LTD.sub.4) inhibitors and therefore useful in the treatment of allergies and inflammatory conditions.
    Type: Grant
    Filed: June 14, 1988
    Date of Patent: December 19, 1989
    Assignee: G. D. Searle and Company
    Inventors: Masateru Miyano, Robert L. Shone, Daniel D. Sohn
  • Substituted dihydrobenzopyrans
    Patent number: 4778903
    Abstract: The invention relates to compounds of the formula: ##STR1## which are useful as leukotriene D.sub.4 (LTD.sub.4) inhibitors and therefore useful in the treatment of allergies and inflammatory conditions.
    Type: Grant
    Filed: December 12, 1984
    Date of Patent: October 18, 1988
    Assignee: G. D. Searle & Co.
    Inventors: Masateru Miyano, Robert L. Shone, Daniel D. Sohn
  • Substituted dihydrobenzopyrans useful as leukotriene D.sub.4 inhibitors
    Patent number: 4665203
    Abstract: The invention relates to compounds of the formula: ##STR1## which are useful as leukotriene D.sub.4 (LTD.sub.4) inhibitors and therefore useful in the treatment of allergies and inflammatory conditions.
    Type: Grant
    Filed: August 12, 1985
    Date of Patent: May 12, 1987
    Assignee: G. D. Searle & Co.
    Inventors: Masateru Miyano, Robert L. Shone, Daniel D. Sohn