Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least sectionwise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: A method of manufacturing a solid formulation product comprising steps of: positioning a platform into a cup comprising an open end comprising a skirt, such that the platform is at least partially received by the cup; then filing the cup with liquid formulation to a predetermined level such that the platform is at least partially submerged in the liquid formulation; solidifying the liquid formulation in the cup to form a solid formulation; once the solid formulation is formed, deforming then releasing the skirt.

Abstract: A drive mechanism for a drug delivery device with a reduced operating loudness includes a dose selector, a housing, and a ratchet with a gear element comprising a plurality of gear teeth connected with the dose selector and a pawl element rotationally constrained to the housing comprising at least one pawl tooth. The at least one pawl tooth engages with the gear teeth and is located opposite to the gear teeth. One of the gear element and the pawl element moves forth and back relative to the other element of the gear and pawl elements along a first direction for de-engagement and re-engagement of the opposite gear teeth and at least one pawl tooth when the gear element rotates relative to the housing during dose setting using the dose selector. The pawl element and/or gear element comprises a noise reduction characteristic at a surface which dampens the noise produced.

Abstract: A system comprises a first member, a second member, and a third member, wherein the first and second members are rotatable relative to the third member, wherein the first and second members are coupled to one another by a dead-angle follower coupling, wherein the dead-angle follower coupling is configured such that the first and second members are rotatable relative to one another, wherein the second and third members are rotationally coupled to one another by a switchable coupling mechanism, wherein the switchable coupling mechanism is switchable between two different states, a locked state and a non-locked state, wherein the maximum torque transferable between the second and third members via the switchable coupling mechanism in the locked state is greater than in the non-locked state, wherein the switchable coupling mechanism is in the locked state when the first member is in a locking position relative to the second member.

Abstract: A system comprises a first member, a second member, and a third member, wherein the first and second members are rotatable relative to the third member, wherein the first and second members are coupled to one another by a dead-angle follower coupling, wherein the dead-angle follower coupling is configured such that the first and second members are rotatable relative to one another, wherein the second and third members are rotationally coupled to one another by a switchable coupling mechanism, wherein the switchable coupling mechanism is switchable between two different states, a locked state and a non-locked state, wherein the maximum torque transferable between the second and third members via the switchable coupling mechanism in the locked state is greater than in the non-locked state, wherein the switchable coupling mechanism is in the locked state when the first member is in a locking position relative to the second member.

Abstract: A drive mechanism for a drug delivery device with a reduced operating loudness includes a dose selector, a housing, and a ratchet with a gear element comprising a plurality of gear teeth connected with the dose selector and a pawl element rotationally constrained to the housing comprising at least one pawl tooth. The at least one pawl tooth engages with the gear teeth and is located opposite to the gear teeth. One of the gear element and the pawl element moves forth and back relative to the other element of the gear and pawl elements along a first direction for de-engagement and re-engagement of the opposite gear teeth and at least one pawl tooth when the gear element rotates relative to the housing during dose setting using the dose selector.

Abstract: A drive train for a wind-up injection device, comprises a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle coupled with a button, a rotationally drivable expelling mechanism, and a clutch element coupled with the torsional energy storage via the rotatable element and comprising a ratchet for maintaining the rotatable element at one of a number of discrete angular positions, wherein via the rotatable element, the clutch element is adapted to transmit a torque from the user handle to the torsional energy storage or from the torsional energy storage to the expelling mechanism, and wherein the ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage, and wherein the drive train is adapted to dampen torque peaks by a flexible impact portion in the area of the clutch element.

Abstract: A system comprises a first member, a second member, and a third member, wherein the first and second members are rotatable relative to the third member, wherein the first and second members are coupled to one another by a dead-angle follower coupling, wherein the dead-angle follower coupling is configured such that the first and second members are rotatable relative to one another, wherein the second and third members are rotationally coupled to one another by a switchable coupling mechanism, wherein the switchable coupling mechanism is switchable between two different states, a locked state and a non-locked state, wherein the maximum torque transferable between the second and third members via the switchable coupling mechanism in the locked state is greater than in the non-locked state, wherein the switchable coupling mechanism is in the locked state when the first member is in a locking position relative to the second member.

Abstract: A drive train (T) for a wind-up injection device (1) for injecting a liquid drug comprises a torsional energy storage (9) adapted to be loaded or unloaded by a rotatable element (6), a rotatable user handle (8), a rotationally driveable expelling mechanism (5) adapted to expel the liquid drug and a clutch element (12) coupled with the torsional energy storage (9) via the rotatable element (6) and comprising a ratchet (12.4) for maintaining the rotatable element (6) at one of a number of discrete angular positions against the torque of the torsional energy storage (9). The clutch element (12) is adapted to transmit a torque from the user handle (8) via the rotatable element (6) to the torsional energy storage (9) or alternatively from the torsional energy storage (9) via the rotatable element (6) to the expelling mechanism (5), wherein the ratchet (12.4) is switchable from one position to an adjacent position by a torque transmitted from the user handle (8) to the torsional energy storage (9).

Abstract: A button (70, 270, 370, 470) for a drug delivery device with a reduced operating loudness comprises a plate-like button body forming a touch surface (70b, 270b, 370b, 470b), wherein the plate-like button body is coupled by an axial supporting member (75, 275, 375, 475) to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body comprises a material composite with at least one first component (271, 272, 371, 372, 373, 374, 471) consisting of a first material and at least one second component (278, 378, 478) consisting of a second material different from the first material, wherein the at least one first component (271, 272, 371, 372, 373, 374, 47) and the at least one second component (278, 378, 478) are coupled via at least one coupling plane (270d, 270e, 370d, 470d) that is at least sectionwise slanted or perpendicular to the longitudinal direction.

Abstract: A drive mechanism (1) for use in a drug delivery device (100) is provided. The drive mechanism (1) comprises a housing (10, 11, 12, 14, 15) with a proximal and a distal end and a piston rod (22) which is rotatable with respect to the housing (10, 11, 12, 14, 15). The drive mechanism (1) further comprises a nut member (31) which is selectively rotationally lockable with respect to the housing (10, 11, 12, 14, 15), wherein the drive mechanism (1) is switchable between a setting mode of operation and a dispensing mode of operation.

Abstract: The invention refers to an injection device comprising a housing (10), containing a cartridge (170) with an amount of liquid to be dispensed, a drive sleeve (41), which is rotationally constrained to the housing (10) during dose setting and spring driven rotatable relative to the housing (10) during dose dispensing, a dose dial member (60) for setting a dose to be dispensed, which is rotatable relative to the housing (10) during dose setting and during dose dispensing, and which is rotationally coupled to the drive sleeve (41) during dose dispensing. The device further comprises a last dose protection mechanism (41, 50, 60) for preventing the setting of a dose, which exceeds the amount of liquid left in the cartridge (170), with a limiter (50), which is interposed between the drive sleeve (41) and the dose dial member (60). Further, the device comprises two different display members (110, 120), each indicating the set dose.

Abstract: The present disclosure concerns an attachment for an operable drug delivery device, comprising a gripping sleeve member that is configured to receive a first member of the operable drug delivery device, wherein the gripping sleeve member comprises a first gripping sleeve member part comprising a first engagement feature at its inner surface that is configured to engage the first gripping sleeve member part in a torque-proof manner with the first member of the operable drug delivery device. Further, the present invention concerns a use of the attachment or a system of attachments for operating the operable drug delivery device.

Abstract: The present invention relates to a dispensing speed control mechanism for use in an injection device. The injection device may have a housing (10, 30, 40; 40?; 40?; 40??) and a drive member (70), which is driven by a power reservoir (100, 100?) and axially movable between a dose setting position, in which the drive member (70) is rotationally constrained to the housing (10, 30, 40; 40?; 40?; 40??), and a dose dispensing position, in which the drive member (70) is rotationally de-coupled from the housing (10, 30, 40; 40?; 40?; 40??). The speed control mechanism comprises friction means (42) for retarding the drive member (70) during dose dispensing depending on the axial position of the drive member (70). Further, the invention relates to an injection device with such a dispensing speed control mechanism.

Abstract: A drive mechanism (1) for use in a drug delivery device (100) is provided. The drive mechanism (1) comprises a housing (10, 11, 12, 14, 15) with a proximal and a distal end and a piston rod (22) which is rotatable with respect to the housing (10, 11, 12, 14, 15). The drive mechanism (1) further comprises a nut member (31) which is selectively rotationally lockable with respect to the housing (10, 11, 12, 14, 15), wherein the drive mechanism (1) is switchable between a setting mode of operation and a dispensing mode of operation.

Abstract: A drug delivery device having a spring element that provides dispense assistance. The drug delivery device includes a variable dose setting mechanism, a fixed dose setting mechanism, and a mechanical coupling having a spring element. The variable dose setting mechanism is operably coupled to a first reservoir holding a first medicament, and the variable dose setting mechanism comprises a dose setter. The fixed dose setting mechanism is operably coupled to a second reservoir holding a second medicament. The mechanical coupling operably couples the variable dose setting mechanism and the fixed dose setting mechanism. Further, the variable dose setting mechanism is configured to set a variable dose of the first medicament upon activation of the dose setter, and the fixed dose setting mechanism is configured to set a fixed dose of the second medicament during variable dose setting.

Abstract: The present invention relates to a handheld automatic injection device comprising a housing (10, 30, 40; 40?), a piston rod (80) located within the housing (10, 30, 40; 40?), a drive member (70) permanently coupled to the piston rod (80), a dose setting member (50), which during dose setting rotates relative to the housing (10, 30, 40; 40?) in a first direction and which during dose dispensing rotates relative to the housing (10, 30, 40; 40?) in a second opposite direction, and a power reservoir (100) for driving the drive member (70). The drive member (70) is axially movable between a dose setting position, in which the drive member (70) is rotationally constrained to the housing, and a dose dispensing position, in which the drive member (70) is rotationally decoupled from the housing (10, 30, 40; 40?).

Abstract: The present invention relates to a dispensing speed control mechanism for use in an injection device. The injection device may have a housing (10, 30, 40; 40?; 40?; 40??) and a drive member (70), which is driven by a power reservoir (100, 100?) and axially movable between a dose setting position, in which the drive member (70) is rotationally constrained to the housing (10, 30, 40; 40?; 40?; 40??), and a dose dispensing position, in which the drive member (70) is rotationally de-coupled from the housing (10, 30, 40; 40?; 40?; 40??). The speed control mechanism comprises friction means (42) for retarding the drive member (70) during dose dispensing depending on the axial position of the drive member (70). Further, the invention relates to an injection device with such a dispensing speed control mechanism.