Abstract: The present disclosure provides methods of preparing pharmaceutical forms using an additive manufacturing techniques to create a final dosing form and the active pharmaceutical ingredient is present as an amorphous solid dispersion. These methods comprise using a preformed amorphous solid dispersion in an additive manufacturing method that results in a composition even after the additional energy has been added that retains its amorphous nature.

Abstract: The disclosure provides for improved methods of formulating pharmaceutical compositions containing weakly basic or weakly acid active pharmaceutical ingredients that are also poorly water-soluble. The methods employ the use of strong bases with weakly acidic APIs and strong acids with weakly basic APIs, thereby improving drug loading.

Abstract: An exhaust fan assembly can include an outer housing, a fan housing mounted to the outer housing, a fan wheel and an electric motor operably coupled to the fan wheel, the fan wheel and electric motor being mounted within the fan housing, wherein the fan housing defines an open inlet side for accepting airflow in a direction generally parallel to a rotational axis of the fan wheel and an outlet for discharging airflow in a direction generally perpendicular to the rotational axis, wherein the fan housing defines a volute section with an outer perimeter having a continuously curved cross-sectional shape.

Abstract: A nonpneumatic tire (NPT) having an inner ring for receiving a hub by which the nonpneumatic tire is affixed to a vehicle or other apparatus, an outer ring encircled by a tread band, and a plurality of revolved and mirrored spokes that extend between the inner ring and the outer ring to form an interconnected web of collapsible open cells. Each of the spokes includes multiple segments, with at least some of the segments having a concave bias when in an unloaded state. The design and arrangement of the spokes results in a nondirectional web, and loads experienced by the NPT are distributed throughout the web in a manner that increases the load carrying capacity of the NPT.

Abstract: Methods and systems are disclosed for prompting a patient to take a blood glucose management action. A diabetes management application on a mobile device can receive diabetes-related information from the mobile device. The diabetes management application can identify a blood glucose management action prompt based on a comparison of the received diabetes-related information to one or more predetermined prompt criteria. The diabetes management application can generate a blood glucose management action prompt based on the blood glucose management action prompt condition. The diabetes management application can present the blood glucose management action prompt to the patient on a user interface of the mobile device.

Abstract: A system for dispensing a detergent solution from a solid detergent into a dishwasher includes a dispenser that can collect water sprayed into the dishwasher and use the collected water to produce the detergent solution by dissolving a portion of the solid detergent, controlling the amount of the detergent solution produced, and releasing the produced detergent solution between cleaning cycles. The dispenser can perform these functions automatically without being electrically powered.

Abstract: A system for dispensing a detergent solution from a solid detergent into a dishwasher includes a dispenser that can collect water sprayed into the dishwasher and use the collected water to produce the detergent solution by dissolving a portion of the solid detergent, controlling the amount of the detergent solution produced, and releasing the produced detergent solution between cleaning cycles. The dispenser can perform these functions automatically without being electrically powered.

Abstract: The present disclosure provides pharmaceutical compositions prepared using an additive manufacturing process where the active pharmaceutical ingredient has been rendered into the amorphous form or prepared as an amorphous solid dispersion at a temperature below the melting point of the active pharmaceutical ingredient or the glass transition of the physical mixture or composition of the individual components. The present disclosure also provides methods of preparing these compositions by using properties such as the chamber and surface temperature and the electron laser density.

Abstract: The present disclosure provides pharmaceutical compositions comprising a thermally conductive excipient which may be used to improve the heat transfer within the pharmaceutical compositions in a high energy mixing process. The resultant pharmaceutical compositions may be amorphous in nature and improve the processability of thermally labile or shear sensitive active agents.

Abstract: A neurovascular access catheter can comprise an elongate, flexible tubular body. The tubular body can comprise a proximal end, a distal end, and a side wall at least partially defining a central lumen. The central lumen can extend axially through the side wall. The tubular body can include a distal microcatheter segment that extends proximally from the distal end. The tubular body can include a proximal shaft that extends distally from the proximal end. The tubular body can include a tapered dilator segment being positioned in between the distal microcatheter segment and the proximal shaft segment.

Abstract: A neurovascular access catheter can comprise an elongate, flexible tubular body. The tubular body can comprise a proximal end, a distal end, and a side wall at least partially defining a central lumen. The central lumen can extend axially through the side wall. The tubular body can include a distal microcatheter segment that extends proximally from the distal end. The tubular body can include a proximal shaft that extends distally from the proximal end. The tubular body can include a tapered dilator segment being positioned in between the distal microcatheter segment and the proximal shaft segment.

Abstract: A space layout system performs various automated layout techniques to generate space layouts for office and other workspaces. The system can access building information modeling (BIM) information fora space, and automatically determine a layout of desks or other furniture for the space. The system can also provide to receive user input and automatically modify or reconfigure the layout of the space using the automated techniques.

Abstract: The biological test kit is a device for drawing and, optionally, testing biological samples. The biological test kit is an array of lancets set in wells in a rigid base. Each lancet well is covered by a protective cover which when deformed permits the lancet to puncture a user or other patient. In one embodiment the biological test kit employs distinct covers for each lancet and in another the covers are formed from sheet material formed into blisters which cover the lancet.

Abstract: Devices, systems and methods to facilitate partially automated production of fluid-filled vaporizer cartridge are disclosed. A device can include a vaporizer cartridge configured to be sealable assembled by a press-fit after filling. Systems and methods include systems and methods for filling an array of partially-assembled vaporizer cartridges and for assembling an array of filled, partially-assembled vaporizer cartridges simultaneously.

Abstract: A medical device that includes a first body including a first actuation wire having a first connector that extends outwardly from the first body, and a second body including a second actuation wire having a second connector that is disposed within the second body. The first connector is configured to engage the second connector in response to the second body mating with the first body, and to deform the second connector in response to the first body disengaging the second body.

Abstract: Devices, systems and methods to facilitate partially automated production of fluid-filled vaporizer cartridges are disclosed. A device can include a vaporizer cartridge configured to be sealably assembled by a press-fit after filling. Systems and methods include systems and methods for filling an array of partially-assembled vaporizer cartridges and for assembling a array of filled, partially-assembled vaporizer cartridges simultaneously.

Abstract: An insect capture device is used to monitor, capture, and/or kill insects. The device has a raised portion to create a gap between a surface and the device to entice insects to pass under. At the raised portion, a glue board includes an adhesive facing the surface. As the insect passes under the raised portion, the insect can unknowingly become attached to the adhesive portion and stuck thereto. To aid in installing the glue board, one or more sections of the glue board can be free of adhesive to connect or fit to a part of the device to hold the glue board in place, while also allowing for easy removal to replace the glue board with a new one, free of captured insects.

Abstract: A neurovascular catheter can have an elongate flexible tubular body. The tubular body can have a proximal end, an inclined distal end, and a side wall that defines a central lumen. The neurovascular catheter can further have a distal leading tip on a first side of the inclined distal end. The neurovascular catheter can further have a preset curve in a distal zone of the tubular body such that wherein the distal leading tip lies on a concave side of the curve.

Abstract: A material wetting system for wetting a powder material includes a liquid supply system, a material mixing unit, a material supply system, and a shroud assembly. The liquid supply system includes a supply line. The material mixing unit is in fluid communication with the supply line and includes a central cavity having an open upper end configured to receive a supply of powder material. The material mixing unit is configured to receive liquid from the supply line and is operatively connected to a reduced pressure source to draw air into the central cavity. The material supply system includes an orifice and is configured to feed powder material through the orifice, with the orifice disposed above the central cavity of the material mixing unit. The shroud assembly is disposed about the open upper end of the central cavity of the material mixing unit and the orifice of the material supply system.

Abstract: A neurovascular catheter has enhanced tensile strength to resist distal tip detachment during proximal retraction past an obstruction. The catheter includes an elongated flexible tubular body, having a proximal end, a distal end and a side wall defining a central lumen. A radiopaque marker is provided adjacent to the distal end. The tensile support extends axially inside the side wall and is attached to the radiopaque marker, to tether the marker to the catheter body. In one implementation, the tensile support may at least partially wrap around the marker. The marker may have a tubular sidewall with a feature to increase compressibility, such as at least one compression gap in a proximal portion of the side wall.