Abstract: A dynamic phantom for use with a functional magnetic resonance imaging (fMRI) device is described. In one example, the dynamic phantom includes an outer housing, an inner cylinder including a removable divider, and a gearbox that can rotate the cylinder, all of which are made from fMRI-compatible materials. The divider forms longitudinal compartments inside the cylinder that can each contain a contrast material. When the cylinder contains contrast materials having at least two different concentrations, and a space between the cylinder and the housing also contains a contrast material, rotation of the cylinder produces biomimetic hemodynamic signals that may be detected by the fMRI device.

Abstract: A dynamic phantom for use with a functional magnetic resonance imaging (fMRI) device is described. In one example, the dynamic phantom includes an outer housing, an inner cylinder including a removable divider, and a gearbox that can rotate the cylinder, all of which are made from fMRI-compatible materials. The divider forms longitudinal compartments inside the cylinder that can each contain a contrast material. When the cylinder contains contrast materials having at least two different concentrations, and a space between the cylinder and the housing also contains a contrast material, rotation of the cylinder produces biomimetic hemodynamic signals that may be detected by the fMRI device.

Abstract: The method of the present disclosure is directed towards a method for determining the concentration of an analyte in a mammal's bloodstream. This method includes the following steps; applying a patch to the mammal's skin, the patch configured to transmit a reporter through the mammal's skin, wherein the reporter is configured to have an affinity for the analyte and is capable of exhibiting a detectable change in fluorescence upon binding to the analyte, subjecting a portion of the mammal's skin to Near Infrared Spectroscopy (NIRS), detecting fluorescence emission intensity and calculating the concentration of the analyte based on the detected fluorescence emission. The system of the present disclosure is directed towards an analyte monitoring system.