Abstract: The present invention provides microparticles that induce the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.

Abstract: The present invention provides microparticles that induce the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.

Abstract: The present invention provides microparticles that induce the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.

Abstract: The present invention provides microparticles that deliver in vivo predictable release profiles of at least one chemokine to create a biomimetic chemokine concentration gradient that induces the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.

Abstract: A flywheel system including a rotor shaft. The rotor shaft includes an inner passage therethrough, and a dam with a central opening disposed on a first end of the inner passage. An outer passage surrounds the inner passage. The inner passage is open at a second end, and the outer passage is closed on an end surrounding the second end of the inner passage. The outer passage is open on an end surrounding the first end of the inner passage. Fluid flows into the inner passage at the first end, via the central opening of the dam. Rotation of the flywheel rotor causes the fluid to accumulate along a wall of the inner passage, and to propagate to the second end, where the fluid exits into the outer passage. The fluid propagates along the outer passage to the open end of the outer passage, where it is released.

Abstract: A flywheel system including a rotor shaft. The rotor shaft includes an inner passage therethrough, and a dam with a central opening disposed on a first end of the inner passage. An outer passage surrounds the inner passage. The inner passage is open at a second end, and the outer passage is closed on an end surrounding the second end of the inner passage. The outer passage is open on an end surrounding the first end of the inner passage. Fluid flows into the inner passage at the first end, via the central opening of the dam. Rotation of the flywheel rotor causes the fluid to accumulate along a wall of the inner passage, and to propagate to the second end, where the fluid exits into the outer passage. The fluid propagates along the outer passage to the open end of the outer passage, where it is released.