Abstract: Provided herein are examples of mRNA treatment nanoparticles and methods of using them to treat a patient. An mRNA treatment nanoparticle may include one or more mRNAs encoding a tumor-specific antigen and an immunomodulatory agent; and a delivery vehicle molecule encapsulating the one or more mRNAs.

Abstract: An improved vertical lift door roller assembly has a wheel pivotally mounted to a shaft. The shaft is placed within a spring loaded locking cylinder. The locking cylinder is movable between a first position where it restricts pivoting of the wheel and a second position where the wheel is able to pivot. The door roller assembly is mountable to a support a vertical lift door, such as a bracket or a hinge. The roller wheel can be pivoted to decouple the roller from a vertical lift door wheel track and to reseat the wheel in the track.

Abstract: Computer-implemented methods and systems for integrating computer applications are disclosed. One method includes querying a primary computer application for current state of a newly created object; receiving the current state of the object, and generating object data for a secondary computer application based on the current state of the object. The method further includes communicating an object creation request to a secondary computer application, the object creation request including the generated object data, receiving a secondary computer application object identifier from the secondary computer application upon creation of the object at the secondary computer application, and communicating the secondary computer application object identifier to the primary computer application for storing in a record of the object created at the primary computer application.

Abstract: An underwater light fixture and a method for making the underwater light fixture are provided. The method includes assembling a light fixture in a housing, leaving a fastener out of the light fixture, wherein an opening for the fastener fluidically couples to open volume in the housing. The housing is placed in a vacuum chamber, and a vacuum is pulled on the vacuum chamber to remove air from the open volume of the housing. A dry gas is introduced into the vacuum chamber to fill the open volume in the housing, and the fastener is installed in the light fixture to seal the open volume.

Abstract: The presently described and disclosed technology includes, in one example, a method, comprising: extracting a sequence of a spike protein of a first virus from a first non-human mammal that is previously exposed to an infection by the first virus; identifying a target antigen specific to the spike protein; and injecting an mRNA therapeutic comprising an mRNA encoding the target antigen into a human patient that has antibodies to a second virus.

Abstract: Mobile communications base stations, such as 5G wireless communications base stations operating at millimeter wave (mmW) frequencies, may have limited spatial coverage due to issues such as limited line of sight or attenuation from foliage or structures. Line of sight and attenuation can be modeled to recommend placement of repeaters for expanded spatial coverage. The repeaters can include open-air repeaters and window repeaters.

Abstract: An underwater light fixture and a method for making the underwater light fixture are provided. The method includes assembling a light fixture in a housing, leaving a fastener out of the light fixture, wherein an opening for the fastener fluidically couples to open volume in the housing. The housing is placed in a vacuum chamber, and a vacuum is pulled on the vacuum chamber to remove air from the open volume of the housing. A dry gas is introduced into the vacuum chamber to fill the open volume in the housing, and the fastener is installed in the light fixture to seal the open volume.

Abstract: An improved vertical lift door roller assembly has a wheel pivotally mounted to a shaft. The shaft is placed within a spring loaded locking cylinder. The locking cylinder is movable between a first position where it restricts pivoting of the wheel and a second position where the wheel is able to pivot. The door roller assembly is mountable to a support a vertical lift door, such as a bracket or a hinge. The roller wheel can be pivoted to decouple the roller from a vertical lift door wheel track and to reseat the wheel in the track.

Abstract: An improved vertical lift door roller assembly has a wheel pivotally mounted to a shaft. The shaft is placed within a spring loaded locking cylinder. The locking cylinder is movable between a first position where it restricts pivoting of the wheel and a second position where the wheel is able to pivot. When the door roller assembly is used on a vertical lift door, the wheel can be pivoted to decouple the roller from a vertical lift door J channel wheel track.

Abstract: An internal balloon projector includes a body insertable through a balloon opening having a power module and a projection module. The projection module receives electrical power from the power module and is operable to project an image onto an inner surface of the balloon when inserted therein. A balloon assembly includes a balloon with the projector inserted therein. The balloon is inflatable via an inflation passage formed within the body, and can be deflated and reinflated. The internal balloon projector can sequentially project multiple images on the inner surface of the balloon.

Abstract: A data processing method comprises creating and storing a dependency graph representing at least one derived dataset and one or more raw datasets or intermediate derived datasets on which the at least one derived dataset depends; reading configuration data specifying one or more periods for one or more datasets in the dependency graph; detecting a first update to a first dataset; initiating a first build of a first intermediate derived dataset only when a then-current time is within a first period of the one or more periods or a previous build of the first intermediate derived dataset occurred earlier than a then-current time less a second period of the one or more periods; asynchronously detecting a second update to a second dataset; initiating, in response to the second update, a second build of a second intermediate derived dataset that depends on the second dataset.

Abstract: Techniques for automatically scheduling builds of derived datasets in a distributed database system that supports pipelined data transformations are described herein.

Abstract: Safety system (100) for use with a personal protective equipment for working in great heights comprising: wireless communication means configured to provide a communication with a rescue coordination center (170); sensor means for providing sensor data comprising at least one acceleration sensor and at least one orientation sensor; evaluation and notification means configured to determine a fall event and/or a loss of consciousness event based on the sensor data and to notify the rescue coordination center (170) via the wireless communication means by sending an alert event message.

Abstract: An improved vertical lift door roller assembly has a wheel pivotally mounted to a shaft. The shaft is placed within a spring loaded locking cylinder. The locking cylinder is movable between a first position where it restricts pivoting of the wheel and a second position where the wheel is able to pivot. When the door roller assembly is used on a vertical lift door, the wheel can be pivoted to decouple the roller from a vertical lift door J channel wheel track.

Abstract: Systems and methods for aggregating and storing different types of data, and generating interactive user interfaces for analyzing the stored data. In some embodiments, entity data is received for a plurality of entities from one or more data sources, and used to determine attribute values for the entities for one or more given time periods. The plurality of entities may be categorized into one or more entity groups, and aggregate attribute values may be generated based upon the entity groups. A first interactive user interface is generated displaying the one or more entity groups in association with the aggregated attribute values associated with the entity group. In response to a received indication of a user selection of an entity group, a second interactive user interface is generated displaying the one or more entities associated with the selected entity group, each entity displayed in association with the attribute values associated with the entity.

Abstract: A mounting system and method secure a power distribution unit within a substrate at sites where access behind the substrate is unavailable to a worker effecting the installation. The power distribution unit is coupled to a trim plate for displacement relative to the trim plate when the trim plate is engaged with an obverse surface of the substrate. Displacement of the power distribution unit relative to the trim plate from a first position into a second position beyond the obverse surface, and then release of the power distribution unit for return toward the first position, in response to a biasing force, enables a retention member to lock the power distribution unit in place within the substrate. Selective removal of the power distribution unit from the substrate is accomplished by lifting the trim plate from the obverse surface of the substrate to effect release of the retention member from the power distribution unit, thereby releasing the power distribution unit from the substrate.

Abstract: In a furniture supported power control arrangement and method, power is controlled selectively from one of two furniture locations in the arrangement. A three-way circuit is comprised of low-voltage wiring connecting a first double-throw electric switch carried at a first furniture location for selective manual actuation, and a second double-throw electric switch carried at a second furniture location for selective manual actuation. A low-voltage driver supplies low-voltage power to the three-way circuit, and a low-voltage room lighting system is connected to the three-way circuit, whereby low-voltage power is directed to or disconnected from the room lighting system as controlled selectively by actuation of either one of the first and second double-throw electric switches.

Abstract: A retrofit device and method adapt an existing, conventional lighting fixture for resisting bio-fouling of a primary window of the lighting fixture when submerged and exposed to biological organisms within a surrounding environment. The primary window is isolated from the surrounding environment by an auxiliary window member, and ultraviolet radiation is directed to the outer surface of the auxiliary window member from a source within the retrofit device, enabling transmission of ultraviolet radiation to the outer surface of the auxiliary window member of an intensity limited to essentially that which is effective in rendering the outer surface of the auxiliary window member immune to permanent adherence of biological organisms to which that outer surface is exposed when submerged, thereby allowing illumination from a source behind the primary window to be projected effectively through the auxiliary window member into the surrounding environment.

Abstract: A retrofit device and method adapt an existing, conventional lighting fixture for resisting bio-fouling of a primary window of the lighting fixture when submerged and exposed to biological organisms within a surrounding environment. The primary window is isolated from the surrounding environment by an auxiliary window member, and ultraviolet radiation is directed to the outer surface of the auxiliary window member from a source within the retrofit device, enabling transmission of ultraviolet radiation to the outer surface of the auxiliary window member of an intensity limited to essentially that which is effective in rendering the outer surface of the auxiliary window member immune to permanent adherence of biological organisms to which that outer surface is exposed when submerged, thereby allowing illumination from a source behind the primary window to be projected effectively through the auxiliary window member into the surrounding environment.

Abstract: Systems and methods for aggregating and storing different types of data, and generating interactive user interfaces for analyzing the stored data. In some embodiments, entity data is received for a plurality of entities from one or more data sources, and used to determine attribute values for the entities for one or more given time periods. The plurality of entities may be categorized into one or more entity groups, and aggregate attribute values may be generated based upon the entity groups. A first interactive user interface is generated displaying the one or more entity groups in association with the aggregated attribute values associated with the entity group. In response to a received indication of a user selection of an entity group, a second interactive user interface is generated displaying the one or more entities associated with the selected entity group, each entity displayed in association with the attribute values associated with the entity.