Abstract: The present invention relates, in part, to methods for large-scale purification of mRNA. The method includes, at least, steps of forming an mRNA slurry, stirring the slurry, and vacuum or pressure filtering the slurry.

Abstract: Disclosed is a method for producing hybrid or non-hybrid recombinant glycoprotein hormones, for example the recombinant equine chorionic gonadotropin (r-eCG), the hybrid recombinant chorionic gonadotropin, the recombinant thyroid-stimulating hormone (r-TSH), the recombinant luteinizing hormone (r-LH), the luteinizing hormone and the recombinant follicle-stimulating hormone (r-FSH). In addition, the present disclosure relates to the recombinant glycoprotein hormones comprising the equine ? and ? subunits, inter alia, the ? subunit of mammals and equine ? subunit, where the two subunits are fused in a simple chain, and chain-modifying agents, which hormones are easier to purify, more homogeneous, easier to produce on an industrial scale without using animals, in comparison with the wild glycoprotein hormone.

Abstract: A device for producing an output light emission having a light source for emitting light and a first polarizing beam splitter element positioned so at least one portion of the emitted light is incident thereupon, wherein a first reflected light beam of a first polarization state and a second transmitted light beam of a second polarization state are produced. The device also includes a first liquid crystal element having at least two states which are actuated using a control unit. The first liquid crystal element at least partially reflects the first light beam, wherein the polarization state of the first light beam is altered based on the state of the first liquid crystal element. The first polarizing beam splitter element is positioned so the first light beam is incident thereupon after reflection at the first liquid crystal element.

Abstract: A device for producing an output light emission having a light source for emitting light and a first polarizing beam splitter element positioned so at least one portion of the emitted light is incident thereupon, wherein a first reflected light beam of a first polarization state and a second transmitted light beam of a second polarization state are produced. The device also includes a first liquid crystal element having at least two states which are actuated using a control unit. The first liquid crystal element at least partially reflects the first light beam, wherein the polarization state of the first light beam is altered based on the state of the first liquid crystal element. The first polarizing beam splitter element is positioned so the first light beam is incident thereupon after reflection at the first liquid crystal element.

Abstract: An illumination system including at least one light source such as an electroluminescent element, e.g. a light emitting diode (LED), and at least one optical element whose surface is structured by diffraction and/or refraction type optical microstructures. In order to shape the beam, the optical element includes at least two sections whose optical microstructures and therefore optical properties are different from one another. The pattern of the microstructures in each of the at least two sections is, at least over a predetermined angular range, rotationally symmetric with respect to the optical axis or another symmetry axis.

Abstract: A method, computer system, and computer program product for generating an outcome-based healthcare contract is provided. The embodiment may include defining an outcome-based contract template between a company and a payer, whereby the outcome-based contract template comprises at least one category of a plurality of patient data to be tracked. The embodiment may include generating a contract for a patient based on the outcome-based contract template, whereby at least one specific value associated to the patient is assigned to each at least one category, and whereby the contract comprises a target outcome for the patient. The embodiment may include monitoring the plurality of patient data associated with the patient. The embodiment may include determining the target outcome is achieved based on the plurality of patient data. The embodiment may include transmitting a plurality of outcome data between the company and the payer based on the determined target outcome being achieved.

Abstract: A well stimulation modeling method and simulation model for modeling a stimulation treatment involving a chemical reaction between a treatment fluid and a porous medium, such as acid treatment of a carbonate formation. In a wormhole initiation stage or mode, the medium of the cells having a solid saturation above a respective critical solid saturation is comprised of matrix material behaving as a single permeability, single porosity system; and in a wormhole growth stage or mode, the cells having a solid saturation equal to or less than the respective critical sold saturation comprise two different interconnected media, the matrix material and a wormhole material, defined to include wormhole-forming material as well as mature wormholes, having fluid mobility as a function of the solid saturation.

Abstract: A gaming system includes a credit mechanism configured to receive credit input by a player for contribution to a credit balance and a display configured to display a plurality of standard symbol positions and optionally one or more additional symbol positions. The system also includes a betting module configured to determine a bet amount and game play instructions on commencement of a game input using a player interface, the bet subtracted from the credit balance. A symbol selector selects symbols for display in the plurality of standard symbol positions and, dependent on the amount wagered, further arranged to select and display symbols in the additional symbol position(s) to increase the probability of a win outcome being generated. An outcome determiner determines an outcome of the game based on the displayed symbol positions.

Abstract: A method of awarding an award on a gaming machine, the method comprising: a) in a random selection process selecting an eligibility criterion or eligibility criteria from a plurality of possible eligibility criteria, whereby the selected criterion or criteria is deemed an active award trigger event; b) monitoring game play activity on the gaming machine for occurrence of the active award trigger event; c) when the active award trigger event occurs as a result of game play activity on the gaming machine, awarding the award; and d) following the completion of step c), or following the occurrence of another event: i) deeming the selected eligibility criterion or criteria an inactive award trigger event; and ii) repeating steps a) to c).

Abstract: A gaming system includes a credit mechanism configured to receive credit input by a player for contribution to a credit balance and a display configured to display a plurality of standard symbol positions and optionally one or more additional symbol positions. The system also includes a betting module configured to determine a bet amount and game play instructions on commencement of a game input using a player interface, the bet subtracted from the credit balance. A symbol selector selects symbols for display in the plurality of standard symbol positions and, dependent on the amount wagered, further arranged to select and display symbols in the additional symbol position(s) to increase the probability of a win outcome being generated. An outcome determiner determines an outcome of the game based on the displayed symbol positions.

Abstract: An illumination system including at least one light source such as an electroluminescent element, e.g. a light emitting diode (LED), and at least one optical element whose surface is structured by diffraction and/or refraction type optical microstructures. In order to shape the beam, the optical element includes at least two sections whose optical microstructures and therefore optical properties are different from one another. The pattern of the microstructures in each of the at least two sections is, at least over a predetermined angular range, rotationally symmetric with respect to the optical axis or another symmetry axis.

Abstract: A triggering method for a win outcome on a gaming device includes determining an amount of credit on commencement of game play. A number of symbols displayed in the game is adjusted as a function of the amount bet, to thereby affect the probability of a win outcome being generated.

Abstract: Embodiments of the present invention provide a diagnostic approach utilizing quantitative polymerase chain reaction (PCR) to detect quantitatively a pathogen of the genus Leifsonia that causes ratoon stunting disease (RSD) in sugarcane. This is a rapid, cost-effective and/or high sensitivity methodology for detecting this pathogen. The present invention relates to methods and kits for detecting a pathogen in a plant, plant part or plant cell from the Gramineae/Poaceae family, such as plants of the Saccharum spp, including sugarcane.

Abstract: A well stimulation modeling method and simulation model for modeling a stimulation treatment involving a chemical reaction between a treatment fluid and a porous medium, such as acid treatment of a carbonate formation. In a wormhole initiation stage or mode, the medium of the cells having a solid saturation above a respective critical solid saturation is comprised of matrix material behaving as a single permeability, single porosity system; and in a wormhole growth stage or mode, the cells having a solid saturation equal to or less than the respective critical sold saturation comprise two different interconnected media, the matrix material and a wormhole material, defined to include wormhole-forming material as well as mature wormholes, having fluid mobility as a function of the solid saturation.

Abstract: An illumination system including at least one light source such as an electroluminescent element, e.g. a light emitting diode (LED), and at least one optical element whose surface is structured by diffraction and/or refraction type optical microstructures. In order to shape the beam, the optical element includes at least two sections whose optical microstructures and therefore optical properties are different from one another. The pattern of the microstructures in each of the at least two sections is, at least over a predetermined angular range, rotationally symmetric with respect to the optical axis or another symmetry axis.

Abstract: A gaming system is disclosed which comprises a display, a symbol selector arranged to select at least a first set of normal symbols to be displayed by the display at a plurality of display positions and to cause a special symbol to be displayed at a display position, a special symbol controller arranged to replicate an aspect of the special symbol until an end condition is met, the special symbol controller arranged to maintain each previously displayed special symbol in the display position where the special symbol occurred, select at least one display position for each replicated aspect of the special symbol and cause each replicated aspect of the special symbol to be displayed at the selected position, and an outcome generator arranged to determine at least one game outcome based on the displayed special symbol, the displayed normal symbols and the replicated aspect of the special symbol. A corresponding method is also disclosed.

Abstract: This invention relates to a computer-based method and system for facilitating the classification of information items. Information items are searched for references to entities of interest, and associated with such entities based on calculated confidence levels that the information items contains a reference to the entities and a category confidence level that the information items relate to the entities.

Abstract: A method of awarding an award on a gaming machine, the method comprising: a) in a random selection process selecting an eligibility criterion or eligibility criteria from a plurality of possible eligibility criteria, whereby the selected criterion or criteria is deemed an active award trigger event; b) monitoring game play activity on the gaming machine for occurrence of the active award trigger event; c) when the active award trigger event occurs as a result of game play activity on the gaming machine, awarding the award; and d) following the completion of step c), or following the occurrence of another event: i) deeming the selected eligibility criterion or criteria an inactive award trigger event; and ii) repeating steps a) to c).

Abstract: A triggering method for a win outcome on a gaming device includes determining an amount of credit on commencement of game play. A number of symbols displayed in the game is adjusted as a function of the amount bet, to thereby affect the probability of a win outcome being generated.

Abstract: A method of awarding an award on a gaming machine is set forth. The method includes selecting an eligibility criterion or eligibility criteria from a plurality of possible eligibility criteria. The selected criterion is deemed to be an active award trigger event. Game play activity on the gaming machine is then monitored for occurrence of this trigger event. When the active award trigger event occurs, the award is awarded. Following award of the award, or following the occurrence of another event, the selected eligibility criterion are rendered inactive award trigger event, and another eligibility criterion is selected as the active award trigger event.