Abstract: Ophthalmic formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided suitable for intravitreal administration to the eye. The ophthalmic formulations include a stable liquid formulation and a lyophilizable formulation. Preferably, the protein antagonist has the amino acid sequence shown in SEQ ID NO:4.

Abstract: Formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided including a pre-lyophilized formulation, a reconstituted lyophilized formulation, and a stable liquid formulation. Preferably, the fusion protein has the sequence of SEQ ID NO:4.

Abstract: Formulations of an interleukin-1 (IL-1) antagonist are provided including a pre-lyophilized formulation, a reconstituted lyophilized formulation, and a stable liquid formulation. Preferably, the IL-1 antagonist is an IL-1 trap composed of a dimer of two fusion protein having an amino acid sequence selected from the group consisting of SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, and 26. Most preferably, the fusion protein has the sequence of SEQ ID NO:10.

Abstract: Demodulation of M-ary continuous-phase FSK signals is effected in accordance with phase measurements taken at symbol transition times. The phase error caused by intersymbol interference is estimated by knowledge of the type and degree of distortion which is principally dependent upon the frequency difference between successive data symbols and phase distortion characteristics of the channel filter. Pairs of phase nodes are selected at each symbol transition time and, from each pair, a tentative choice is made by using the expected phase distortion based on adjacent phase node pairs. Refined choices are then made using the estimated phase distortion based on adjacent tentative choices. Differences between successive tentative choices of phase node selections yield a sequence of frequencies making up the FSK signal. Circuitry implementation embraces the use of phase-locked loop detectors and digital decision logic including programmable read-only memories.

Abstract: A coherent phase detector using a frequency discriminator for reducing a frequency encoded signal to baseband, thereby avoiding the necessity of generating a coherent RF phase reference signal. A baseband processor is provided to compensate for error components arising in the frequency discriminator output. The baseband processor includes feedback loops for DC level correction and automatic gain correction. A novel scheme is also described for reducing the influence of interbit crosstalk on the operation of the baseband processor.