Abstract: A tissue removing device and brush construction, and more particularly, a cytology brush construction which is intended to be utilized in conjunction with a specimen sampling device for the collection of microbiological biopsy specimen from a body cavity. The brush construction is attained by the provision of at least one initially flat element which may have at least one or opposing longitudinal outer edges in either a wavy-linear configuration, rectilinear form, or which may incorporate a multiplicity of closely spaced, parallel slits cut in from at least one longitudinal edge so as to leave a central longitudinal connecting web in the element.