Abstract: Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.

Abstract: Blast, ballistic, and entry resistant operable window systems include a sliding exterior glazing panel assembly, a sliding interior glazing panel assembly, an exterior frame assembly that receives the sliding exterior glazing panel assembly, an interior frame assembly that receives the sliding interior glazing panel assembly, an exterior gasket for placement between the exterior frame assembly and the wall of the building, a central gasket for placement between the exterior frame assembly and the interior frame assembly, and an interior gasket for placement between the interior frame assembly and the wall of the building. Methods of installation in a wall of a building are also provided.

Abstract: Blast, ballistic, and entry resistant compression frame systems include a plurality of bolts, an exterior frame assembly having a peripheral flange and a plurality of sleeves that receive the bolts, an interior frame assembly having a peripheral flange and a plurality of apertures that receive the bolts therethrough, an exterior gasket between the peripheral flange of the exterior frame assembly and an exterior surface of the wall of the building, and an interior gasket between the peripheral flange of the interior frame assembly and an interior surface of the wall of the building. The exterior frame assembly peripheral flange and the interior frame assembly peripheral flange apply a compression force to the wall when the bolts are torque tightened into the threaded sleeves. Methods of installation in a wall of a building are also provided.

Abstract: Blast, ballistic, and entry resistant compression frame systems include a plurality of bolts, an exterior frame assembly having a peripheral flange and a plurality of sleeves that receive the bolts, an interior frame assembly having a peripheral flange and a plurality of apertures that receive the bolts therethrough, an exterior gasket between the peripheral flange of the exterior frame assembly and an exterior surface of the wall of the building, and an interior gasket between the peripheral flange of the interior frame assembly and an interior surface of the wall of the building. The exterior frame assembly peripheral flange and the interior frame assembly peripheral flange apply a compression force to the wall when the bolts are torque tightened into the threaded sleeves. Methods of installation in a wall of a building are also provided.

Abstract: In one embodiment, a system, comprising: a damper assembly, the damper assembly comprising: a structural member; at least one door pivotably coupled to the structural member; a clip connected to the damper assembly and comprising plural spring end constraining segments; a spring comprising a first end and a second end, wherein at least the first end comprises a hook, the spring coupled at the first end to one of the plural spring end constraining segments and at the second end fixably coupled to the damper assembly, the clip configured to accept a hookable connection to the spring at any one of the plural spring end constraining segments, each of the plural spring end constraining segments constraining movement of the hook, when connected thereto, during opening and closing of the at least one door, wherein the spring is at a first tension when hooked to the one of the plural spring end constraining segments and at a second tension when hooked to another of the plural spring end constraining segments.

Abstract: In one embodiment, a system, comprising: a damper assembly, the damper assembly comprising: a structural member; at least one door pivotably coupled to the structural member; a clip connected to the damper assembly and comprising plural spring end constraining segments; a spring comprising a first end and a second end, wherein at least the first end comprises a hook, the spring coupled at the first end to one of the plural spring end constraining segments and at the second end fixably coupled to the damper assembly, the clip configured to accept a hookable connection to the spring at any one of the plural spring end constraining segments, each of the plural spring end constraining segments constraining movement of the hook, when connected thereto, during opening and closing of the at least one door, wherein the spring is at a first tension when hooked to the one of the plural spring end constraining segments and at a second tension when hooked to another of the plural spring end constraining segments.

Abstract: A system for measuring forces from a rotating object is presented. In one aspect, the measurement system has a plurality of strain sensors that are configured to attach to the sidewall of a tire of a vehicle and measure the strain on the sidewall. The system can also have a data processor to relate the strain on the sidewall to the normal force exerted on the driving surface from the tire.

Abstract: Various methods and devices are provided for allowing multiple surgical instruments to be inserted into sealing elements of a single surgical access device. The sealing elements can be movable along predefined pathways within the device to allow surgical instruments inserted through the sealing elements to be moved laterally, rotationally, angularly, and vertically relative to a central longitudinal axis of the device for ease of manipulation within a patient's body while maintaining insufflation.

Abstract: A system for measuring forces from a rotating object is presented. In one aspect, the measurement system has a plurality of strain sensors that are configured to attach to the sidewall of a tire of a vehicle and measure the strain on the sidewall. The system can also have a data processor to relate the strain on the sidewall to the normal force exerted on the driving surface from the tire.

Abstract: Various methods and devices are provided for allowing multiple surgical instruments to be inserted into sealing elements of a single surgical access device. The sealing elements can be movable along predefined pathways within the device to allow surgical instruments inserted through the sealing elements to be moved laterally, rotationally, angularly, and vertically relative to a central longitudinal axis of the device for ease of manipulation within a patient's body while maintaining insufflation.

Abstract: A trocar sleeve includes a trocar cannula and a trocar housing having a housing member base and a housing member cover. The trocar cannula and trocar housing are mechanically interfitted to form a trocar sleeve, wherein at least a portion of the trocar cannula sits within the housing member base with the housing member cover sitting over the trocar cannula for securing the at least a portion of the trocar cannula within the housing member base. The trocar sleeve also includes a stop-cock valve mechanically interfitted between the trocar cannula and the trocar housing.