Abstract: The present disclosure relates to compounds of Formula (I) which are multimeric forms of a monomeric binding peptide linearly bonded to PEG moieties to form the multimers. The multimeric forms stimulate angiogenesis and promote wound healing. The disclosure also includes pharmaceutical compositions comprising the multimers, including compositions suitable for topical or systemic administration.

Abstract: The present disclosure relates to compounds of Formula (I) which are multimeric forms of a monomeric binding peptide linearly bonded to PEG moieties to form the multimers. The multimeric forms stimulate angiogenesis and promote wound healing. The disclosure also includes pharmaceutical compositions comprising the multimers, including compositions suitable for topical or systemic administration.

Abstract: The present disclosure relates to compounds of Formula (I) which are multimeric forms of a monomeric binding peptide linearly bonded to PEG moieties to form the multimers. The multimeric forms stimulate angiogenesis and promote wound healing. The disclosure also includes pharmaceutical compositions comprising the multimers, including compositions suitable for topical or systemic administration.

Abstract: The present disclosure relates to compounds of Formula (I) which are multimeric forms of a monomeric binding peptide linearly bonded to PEG moieties to form the multimers. The multimeric forms stimulate angiogenesis and promote wound healing. The disclosure also includes pharmaceutical compositions comprising the multimers, including compositions suitable for topical or systemic administration.

Abstract: The present disclosure provides methods and uses of Tie2 agonists alone or in combination with antiviral agents. In particular, the present disclosure provides methods and uses for treating influenza, treating a bacterial superinfection associated with influenza and decreasing lung endothelial leakage. The disclosure also provides compositions comprising (a) a Tie2 agonist and (b) an antiviral agent and methods and uses thereof.

Abstract: The present invention provides a multimeric form of a Tie 2 binding peptide monomer, wherein the multimeric form has Tie 2 agonist activity. The multimeric form, preferably a tetramer, stimulates angiogenesis and promotes wound healing. The present invention also features pharmaceutical compositions comprising the multimeric Tie 2 agonists, including those suitable for topical or systemic administration. Methods of using the multimeric Tie 2 agonists of the invention for stimulating angiogenesis and for promoting healing of wounds, such as diabetic ulcers or skin grafts, are also provided.

Abstract: The present disclosure provides methods and uses of Tie2 agonists alone or in combination with antiviral agents. In particular, the present disclosure provides methods and uses for treating influenza, treating a bacterial superinfection associated with influenza and decreasing lung endothelial leakage. The disclosure also provides compositions comprising (a) a Tie2 agonist and (b) an antiviral agent and methods and uses thereof.

Abstract: The present disclosure provides methods and uses of Tie2 binding and/or activating agents. In particular, the present disclosure provides methods and uses for inhibiting the expansion of colony forming unit-granulocytes, reducing eosinophils and/or basophils, for treating allergic disease or response or eosinophil/basophil associated condition and for reducing inflammatory cytokine and/or chemokine levels.

Abstract: The present invention provides a multimeric form of a Tie 2 binding peptide monomer, wherein the multimeric form has Tie 2 agonist activity. The multimeric form, preferably a tetramer, stimulates angiogenesis and promotes wound healing. The present invention also features pharmaceutical compositions comprising the multimeric Tie 2 agonists, including those suitable for topical or systemic administration. Methods of using the multimeric Tie 2 agonists of the invention for stimulating angiogenesis and for promoting healing of wounds, such as diabetic ulcers or skin grafts, are also provided.

Abstract: The present invention provides a multimeric form of a Tie 2 binding peptide monomer, wherein the multimeric form has Tie 2 agonist activity. The multimeric form, preferably a tetramer, stimulates angiogenesis and promotes wound healing. The present invention also features pharmaceutical compositions comprising the multimeric Tie 2 agonists, including those suitable for topical or systemic administration. Methods of using the multimeric Tie 2 agonists of the invention for stimulating angiogenesis and for promoting healing of wounds, such as diabetic ulcers or skin grafts, are also provided.

Abstract: The present disclosure provides methods and uses of Tie2 binding and/or activating agents. In particular, the present disclosure provides methods and uses for inhibiting the expansion of colony forming unit-granulocytes, reducing eosinophils and/or basophils, for treating allergic disease or response or eosinophil/basophil associated condition and for reducing inflammatory cytokine and/or chemokine levels.

Abstract: The present invention provides a multimeric form of a Tie 2 binding peptide monomer, wherein the multimeric form has Tie 2 agonist activity. The multimeric form, preferably a tetramer, stimulates angiogenesis and promotes wound healing. The present invention also features pharmaceutical compositions comprising the multimeric Tie 2 agonists, including those suitable for topical or systemic administration. Methods of using the multimeric Tie 2 agonists of the invention for stimulating angiogenesis and for promoting healing of wounds, such as diabetic ulcers or skin grafts, are also provided.

Abstract: A retractable mirror assembly for a vehicle which retracts towards and extends away from a vehicle body wherein the mirror compensates for the change in position so that the same perspective is maintained. The mirror assembly comprises the vehicle body in which a mirror housing that surrounds a mirror backing plate having a mirror glass is retracted and expanded to and from the vehicle body. A second support bracket and a stationary bracket are connected and move in relation to one another in order to rotate the mirror backing plate and mirror so that the mirror maintains the same perspective while the mirror assembly is being retracted and expanded to and from the vehicle body.

Abstract: An exterior rear view mirror for a vehicle has a housing pivotally mounted on a base for angular movement about a first pivot axis and an electric motor for causing such movement. A controller operates the motor at either of two different speeds. The controller includes a counter for counting the number of revolutions of the output shaft of the motor so as to determining the angle through which the housing has been moved, thus enabling the housing to be restored to its original position by causing the motor to perform the same number of revolutions in the opposite direction.

Abstract: A retractable mirror assembly for a vehicle which retracts towards and extends away from a vehicle body wherein the mirror compensates for the change in position so that the same perspective is maintained. The mirror assembly comprises the vehicle body in which a mirror housing that surrounds a mirror backing plate having a mirror glass is retracted and expanded to and from the vehicle body. A second support bracket and a stationary bracket are connected and move in relation to one another in order to rotate the mirror backing plate and mirror so that the mirror maintains the same perspective while the mirror assembly is being retracted and expanded to and from the vehicle body.

Abstract: A side view mirror including a multiplexor chip, NTC thermistor within the housing. The multiplexor controls multiple functionality from the housing and provides simplified LIN bus connection to the vehicle.

Abstract: A side view mirror including a multiplexor chip, NTC thermistor within the housing. The multiplexor controls multiple functionality from the housing and provides simplified LIN bus connection to the vehicle.

Abstract: The subject invention is a bracketless rearview mirror assembly (10) that is inexpensive and provides an easy assembly technique to attach the mirror assembly to a side of a motor vehicle (12). The mirror assembly includes a case (14) with a reflective mirror (16) and a guide mechanism (26). The motor vehicle (12) includes a mounting surface (48) with an opening (52) disposed between an inner side (48) and an outer side (50). A connector (42) is positioned between the case (14) and the inner side (48) of the mounting surface (46) of the vehicle. An adjustment mechanism (20) extends from inside the case, through the guide mechanism (26) and the connector (42), to the inner side (48) of the mounting surface (46). The adjustment mechanism (20) can be a simple handle (68) for manual adjustment or a harness (84) for encapsulating electronic controls for electrically adjusted mirrors.

Abstract: The invention concerns a vehicle rear view mirror, notably for an automobile, comprising a casing that contains an entrance sealed by a mirror, first drive means for pivoting the mirror on a first axis, second drive means for pivoting said mirror on a second axis perpendicular to the first axis and control means for selectively actuating the first and second drive means, the control means comprising a single rotating drive motor device.

Abstract: A heated mirror is provided. The mirror includes a plastic or glass substrate. A contact surface is provided for receiving a resistive heating layer. A plurality of spaced electrodes are electrically coupled to the resistive heating layer for inducing a current in the resistive heating layer to heat the mirror assembly. The substrate is polished in the direction of current flow through the resistive layer. The assembly may also include a separate reflective layer.