Patents by Inventor Daniel Durocher

Daniel Durocher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIMERIZATION SCREENING ASSAYS
    Publication number: 20240110920
    Abstract: The present disclosure relates to compositions of matter and assay methods used to screen for molecular dimerization events using a two-ribonucleoprotein complex signal boost assay. The compositions and methods provide a readout upon detection of dimerization of molecules and may be implemented in a high throughput manner using libraries of tens to hundreds to thousands of putative binding partners.
    Type: Application
    Filed: September 23, 2023
    Publication date: April 4, 2024
    Inventor: Daniel Durocher
  • Treatment of homologous recombination deficient cancers
    Patent number: 11897925
    Abstract: Disclosed are compounds, compositions, uses and methods using inhibitors of the CIP2A-TOPBP1 complex or agents that inhibit phosphopeptide recognition of TOPBP1 BRCT7/8, for treatment of a cancer associated with or characterized by a homologous recombination (HR) deficiency or treatment of cancer cells having HR deficiency.
    Type: Grant
    Filed: November 6, 2021
    Date of Patent: February 13, 2024
    Assignee: Sinai Health System
    Inventors: Daniel Durocher, Salomé Adam, Silvia Emma Rossi, Yibo Xue
  • METHODS OF USING MYT1 INHIBITORS
    Publication number: 20230158022
    Abstract: Disclosed are methods of using inhibitors of tyrosine and threonine-specific cdc2-inhibitory kinase (Myt1), e.g., in the treatment of subjects in need thereof.
    Type: Application
    Filed: April 1, 2021
    Publication date: May 25, 2023
    Inventors: Daniel DUROCHER, Jordan YOUNG, Frank SICHERI, Janek SZYCHOWSKI, Bingcan LIU, Evelyne DIETRICH, Frédéric VALLÉE, Alexander PERRYMAN, Jean-François TRUCHON, Robert PAPP, Theresa ZHANG, Artur VELOSO, Jimmy FOURTOUNIS, Patrick BEAULIEU
  • Treatment of Homologous Recombination Deficient Cancers
    Publication number: 20220153793
    Abstract: Disclosed are compounds, compositions, uses and methods using inhibitors of the CIP2A-TOPBP1 complex or agents that inhibit phosphopeptide recognition of TOPBP1 BRCT7/8, for treatment of a cancer associated with or characterized by a homologous recombination (HR) deficiency or treatment of cancer cells having HR deficiency.
    Type: Application
    Filed: November 6, 2021
    Publication date: May 19, 2022
    Inventors: Daniel Durocher, Salomé Adam, Silvia Emma Rossi, Yibo Xue
  • Homologous recombination factors
    Patent number: 11261466
    Abstract: The invention relates to factors that influence or regulate homologous recombination, methods to monitor these factors, the use of these factors to screen for agents that modulate homologous recombination, and methods to activate or modulate homologous recombination.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: March 1, 2022
    Assignee: Sinai Health System
    Inventors: Daniel Durocher, Alexandre Orthwein, Sylvie Noordermeer
  • Ubiquitin variants and uses therof as 53BP1 inhibitors
    Patent number: 10808017
    Abstract: 53BP1 inhibitors, compositions comprising the inhibitors and methods of using same are provided. The inhibitors can be used in combination with gene editing systems.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: October 20, 2020
    Assignees: The Governing Council of the University of Toronto, Sinai Health System
    Inventors: Daniel Durocher, Sachdev Sidhu, Wei Zhang, Frank Sicheri, Marella Canny
  • UBIQUITIN VARIANTS AND USES THEROF AS 53BP1 INHIBITORS
    Publication number: 20190010196
    Abstract: 53BP1 inhibitors, compositions comprising the inhibitors and methods of using same are provided. The inhibitors can be used in combination with gene editing systems.
    Type: Application
    Filed: January 31, 2017
    Publication date: January 10, 2019
    Inventors: Daniel Durocher, Sachdev Sidhu, Wei Zhang, Frank Sicheri, Marella Canny
  • HOMOLOGOUS RECOMBINATION FACTORS
    Publication number: 20180073039
    Abstract: The invention relates to factors that influence or regulate homologous recombination, methods to monitor these factors, the use of these factors to screen for agents that modulate homologous recombination, and methods to activate or modulate homologous recombination.
    Type: Application
    Filed: March 1, 2016
    Publication date: March 15, 2018
    Inventors: Daniel Durocher, Alexandre Orthwein, Sylvie Noordermeer
  • Apparatus for occupant detection
    Publication number: 20060066085
    Abstract: An apparatus for occupant detection in a vehicle, including a dielectric substrate with a reference plane, and a plurality of electrodes forming a capacitive array on said dielectric substrate and coupled to said reference plane. Each of the plurality of electrodes being formed of a conductive polymer thick film ink. The plurality of electrodes and the reference plane are connected to a controller that detects a change in capacitance between the plurality of electrodes and the reference plane, and identifies the presence and type of occupant in the vehicle.
    Type: Application
    Filed: September 28, 2005
    Publication date: March 30, 2006
    Inventor: Daniel DuRocher
  • Yeast proteome analysis
    Publication number: 20030162221
    Abstract: Methods and reagents for high throughput analysis of protein-protein interaction networks using mass spectrometry.
    Type: Application
    Filed: September 23, 2002
    Publication date: August 28, 2003
    Inventors: Gary Bader, Shane Climie, Daniel Durocher, Joseph Michael Daniel Figeys, Albrecht Gruhler, Adrian Mark Heilbut, Yuen Ho, Lynda A. Moore, Michael Moran, Brenda Muskat, Michael Tyers, Cheryl Deanna Wolting