Patents by Inventor Daniel E. BECK

Daniel E. BECK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aza-A-ring indenoisoquinoline topoisomerase I poisons
    Patent number: 10759795
    Abstract: The invention described herein pertains to four series of aza-A-ring indenoisoquinolines, which are inhibitors of topoisomerase IB (Top1), and the processes for preparing said aza-A-ring indenoisoquinolines. Also described are methods for treating cancer in mammals using the described aza-A-ring indenoisoquinoline compounds or pharmaceutical formulations thereof.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: September 1, 2020
    Assignees: PURDUE RESEARCH FOUNDATION, UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Mark S. Cushman, Daniel E. Beck, Yves Pommier
  • AZA-A-RING INDENOISOQUINOLINE TOPOISOMERASE I POISONS
    Publication number: 20190382401
    Abstract: The invention described herein pertains to four series of aza-A-ring indenoisoquinolines, which are inhibitors of topoisomerase IB (Top1), and the processes for preparing said aza-A-ring indenoisoquinolines. Also described are methods for treating cancer in mammals using the described aza-A-ring indenoisoquinoline compounds or pharmaceutical formulations thereof.
    Type: Application
    Filed: March 15, 2017
    Publication date: December 19, 2019
    Applicant: Purdue Research Foundation
    Inventors: Mark S. CUSHMAN, Daniel E. BECK, Yves POMMIER
  • N-substituted indenoisoquinolines and syntheses thereof
    Patent number: 9388211
    Abstract: N-Substituted indenoisoquinoline compounds, and pharmaceutical formulations of N-substituted indenoisoquinoline compounds are described. Also described are processes for preparing N-substituted indenoisoquinoline compounds. Also described are methods for treating cancer in mammals using the described N-substituted indenoisoquinoline compounds or pharmaceutical formulations thereof.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: July 12, 2016
    Assignees: Purdue Research Foundation, NATIONAL INSTITUTES OF HEALTH (NIH)
    Inventors: Mark S. Cushman, Andrew E. Morrell, Muthukaman Nagarajan, Yves George Pommier, Smitha Antony, Keli K. Agama, Daniel E. Beck
  • N-substituted indenoisoquinolines and syntheses thereof
    Patent number: 9217010
    Abstract: N-Substituted indenoisoquinoline compounds, and pharmaceutical formulations of N-substituted indenoisoquinoline compounds are described. Also described are processes for preparing N-substituted indenoisoquinoline compounds. Also described are methods for treating cancer in mammals using the described N-substituted indenoisoquinoline compounds or pharmaceutical formulations thereof.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: December 22, 2015
    Assignees: PURDUE RESEARCH FOUNDATION, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Mark S. Cushman, Andrew E. Morrell, Muthukaman Nagarajan, Yves G. Pommier, Keli K. Agama, Smitha Antony, Daniel E. Beck
  • N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF
    Publication number: 20150218207
    Abstract: N-Substituted indenoisoquinoline compounds, and pharmaceutical formulations of N-substituted indenoisoquinoline compounds are described. Also described are processes for preparing N-substituted indenoisoquinoline compounds. Also described are methods for treating cancer in mammals using the described N-substituted indenoisoquinoline compounds or pharmaceutical formulations thereof.
    Type: Application
    Filed: April 15, 2015
    Publication date: August 6, 2015
    Inventors: Mark S. CUSHMAN, Andrew E. MORRELL, Muthukaman NAGARAJAN, Yves George POMMIER, Smitha ANTONY, Keli K. AGAMA, Daniel E. BECK