Patents by Inventor Daniel E. Michele

Daniel E. Michele has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • QUANTIFICATION OF INTERMITTENT FUNCTION OF BAROREFLEX FROM CONTINUOUS ARTERIAL PRESSURE DATA
    Publication number: 20210393188
    Abstract: An apparatus for measuring arterial pulse and heart rate of a subject includes a wearable sensor assembly configured to be attached to the subject to measure the blood pressure of the subject. The apparatus further includes a signal processor configured to receive blood pressure data from the wearable sensor assembly and to perform time-series analysis on the blood pressure data. The processor then determines baroreflex functionality of the patient, from the blood pressure data. Further, the processor determines an indication of hypertension in the subject from the baroreflex functionality.
    Type: Application
    Filed: June 21, 2021
    Publication date: December 23, 2021
    Inventors: Daniel A. Beard, Daniel E. Michele, Brian E. Carlson, Feng Gu
  • Compositions and methods for treating and preventing cardiomyopathy and heart disease
    Patent number: 8580245
    Abstract: The present invention relates to compositions and methods for treating and preventing heart disease. In particular, the present invention provides compositions comprising poloxamers (e.g., poloxamer 188-P188) and methods of using the same for treating and preventing heart disease (e.g., in subjects with muscular dystrophy) and for treating cells and tissue damage caused by ischemia and cell death (e.g., for treating dystrophin-deficient cells (e.g., myocytes)).
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: November 12, 2013
    Assignee: The Regents of the University of Michigan
    Inventors: Joseph M. Metzger, Dewayne Townsend, Soichiro Yasuda, Daniel E. Michele
  • COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING CARDIOMYOPATHY AND HEART DISEASE
    Publication number: 20110044935
    Abstract: The present invention relates to compositions and methods for treating and preventing heart disease. In particular, the present invention provides compositions comprising poloxamers (e.g., poloxamer 188-P188) and methods of using the same for treating and preventing heart disease (e.g., in subjects with muscular dystrophy) and for treating cells and tissue damage caused by ischemia and cell death (e.g., for treating dystrophin-deficient cells (e.g., myocytes)).
    Type: Application
    Filed: October 29, 2010
    Publication date: February 24, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Joseph M. Metzger, Dewayne Townsend, Soichiro Yasuda, Daniel E. Michele
  • Compositions and methods for treating and preventing cardiomyopathy and heart disease
    Patent number: 7846426
    Abstract: The present invention relates to compositions and methods for treating and preventing heart disease. In particular, the present invention provides compositions comprising poloxamers (e.g., poloxamer 188—P188) and methods of using the same for treating and preventing heart disease (e.g., in subjects with muscular dystrophy) and for treating cells and tissue damage caused by ischemia and cell death (e.g., for treating dystrophin-deficient cells (e.g., myocytes)).
    Type: Grant
    Filed: February 27, 2006
    Date of Patent: December 7, 2010
    Assignee: The Regents of the University of Michigan
    Inventors: Joseph M. Metzger, Dewayne Townsend, Soichiro Yasuda, Daniel E. Michele
  • Compositions and Methods for Treating and Preventing Cardiomyopathy and Heart Disease
    Publication number: 20080260681
    Abstract: The present invention relates to compositions and methods for treating and preventing heart disease. In particular, the present invention provides compositions comprising poloxamers (e.g., poloxamer 188-P1 88) and methods of using the same for treating and preventing heart disease (e.g., in subjects with muscular dystrophy) and for treating cells and tissue damage caused by ischemia and cell death (e.g., for treating dystrophin-deficient cells (e.g., myocytes)).
    Type: Application
    Filed: February 27, 2006
    Publication date: October 23, 2008
    Inventors: Joseph M. Metzger, Dewayne Townsend, Soichiro Yasuda, Daniel E. Michele