Patents by Inventor Daniel E. Rasmussen

Daniel E. Rasmussen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • O-linked glycoforms of polypeptides and method to manufacture them
    Patent number: 10844110
    Abstract: The present invention relates to compositions comprising glycoproteins having altered patterns of O-linked glycosylation, in particular Factor VII, Factor IX, and methods for making these.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: November 24, 2020
    Assignee: Novo Nordisk Healthcare AG
    Inventors: Niels Kristian Klausen, Daniel E. Rasmussen
  • O-Linked Glycoforms Of Polypeptides And Method To Manufacture Them
    Publication number: 20180057566
    Abstract: The present invention relates to compositions comprising glycoproteins having altered patterns of O-linked glycosylation, in particular Factor VII, Factor IX, and methods for making these.
    Type: Application
    Filed: October 9, 2017
    Publication date: March 1, 2018
    Inventors: Niels Kristian Klausen, Daniel E. Rasmussen
  • Reduction of the content of protein contaminants in compositions comprising a vitamin K-dependent protein of interest
    Patent number: 9187549
    Abstract: The present invention relates to Vitamin K-dependent protein compositions having a very low, or negligible, content of protein contaminants. The present invention also relates to method applicable in the preparation of such Vitamin K-dependent protein compositions. Such methods may either be used alone or in sequential combination with the purpose of reducing the relative content of protein contaminants. The present invention is particularly relevant in the preparation of compositions of coagulation factors selected from Factor X polypeptides (FX/FXa), Factor IX polypeptides (FIX/FIXa), Factor VII polypeptides (FVII/FVIIa), and the anticoagulant Protein C, in particular Factor VII polypeptides.
    Type: Grant
    Filed: December 23, 2005
    Date of Patent: November 17, 2015
    Assignee: Novo Nordisk Healthcare A/G
    Inventors: Janus Krarup, Thomas Budde Hansen, Anne Charlotte Arentsen, Daniel E. Rasmussen, Are Bogsnes, Arne Staby, Haleh Ahmadian, Susanne Bang
  • Hydrophobic interaction chromatography purification of factor VII polypeptides
    Patent number: 9023992
    Abstract: The invention described herein provides new methods of preparing purified Factor VII polypeptide drug substances in large quantities (industrial scale levels) that are associated with reduced content of product-related impurities (e.g., late eluting peaks) and/or that exhibit a relatively uniform glycosylation pattern.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: May 5, 2015
    Assignee: Novo Nordisk Healthcare AG
    Inventors: Daniel E. Rasmussen, Janus Krarup
  • Purification of proteins using preparative reverse phase chromatography (RPC)
    Patent number: 8921518
    Abstract: The present invention provides a method for industrial-scale protein separation by reverse phase chromatography by use of a buffer system and an additional salt.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: December 30, 2014
    Assignee: Novo Nordisk A/S
    Inventors: Daniel E. Rasmussen, Arne Staby, John Strikart Nielsen, Ole Schou
  • ANTIBODY PURIFICATION PROCESS
    Publication number: 20110105725
    Abstract: The invention concerns a method for the industrial production of antibodies.
    Type: Application
    Filed: May 15, 2009
    Publication date: May 5, 2011
    Inventors: Bjarne Rønfeldt Nielsen, Hanne Christensen, Daniel E. Rasmussen, Thomas Budde Hansen, John Strikart Nielsen, Erik Halkjaer, Rikke Christina Nielsen, Christina Jespersgaard, Arne Staby
  • HYDROPHOBIC INTERACTION CHROMATOGRAPHY PURIFICATION OF FACTOR VII POLYPEPTIDES
    Publication number: 20110064719
    Abstract: The invention described herein provides new methods of preparing purified Factor VII polypeptide drug substances in large quantities (industrial scale levels) that are associated with reduced content of product-related impurities (e.g., late eluting peaks) and/or that exhibit a relatively uniform glycosylation pattern.
    Type: Application
    Filed: September 17, 2010
    Publication date: March 17, 2011
    Applicant: Novo Nordisk A/S
    Inventors: DANIEL E. RASMUSSEN, JANUS KRARUP
  • PURIFICATION OF PROTEINS USING PREPARATIVE REVERSE PHASE CHROMATOGRAPHY (RPC)
    Publication number: 20090036652
    Abstract: The present invention provides a method for industrial-scale protein separation by reverse phase chromatography by use of a buffer system and an additional salt.
    Type: Application
    Filed: December 21, 2006
    Publication date: February 5, 2009
    Applicant: Novo Nordisk A/S
    Inventors: Daniel E. Rasmussen, Arne Staby, John Strikart Nielsen, Ole Schou
  • Reduction of the Content of Protein Contaminents in Compositions Comprising a Vitamin K-Dependent Protein of Interest
    Publication number: 20080207880
    Abstract: The present invention relates to Vitamin K-dependent protein compositions having a very low, or negligible, content of protein contaminants. The present invention also relates to method applicable in the preparation of such Vitamin K-dependent protein compositions. Such methods may either be used alone or in sequential combination with the purpose of reducing the relative content of protein contaminants. The present invention is particularly relevant in the preparation of compositions of coagulation factors selected from Factor X polypeptides (FX/FXa), Factor IX polypeptides (FIX/FIXa), Factor VII polypeptides (FVII/FVIIa), and the anticoagulant Protein C, in particular Factor VII polypeptides.
    Type: Application
    Filed: December 23, 2005
    Publication date: August 28, 2008
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Janus Krarup, Thomas Budde Hansen, Anne Charlotte Arentsen, Daniel E. Rasmussen, Are Bognes, Arne Staby, Haleh Ahmadian, Susanne Bang