Abstract: A computing system receives user input selecting a first search folder in a hierarchical set of search folders for a collection of documents. The system identifies documents of the first search folder by: (i) executing a predefined query specified for the first search folder to dynamically retrieve documents, if any, from the collection of documents, that satisfy the specified query, (ii) identifying documents, if any, from the collection of documents, that are individually associated with the first search folder, (iii) determining whether the search folder includes one or more subfolders, and (iv) in accordance with a determination that the search folder includes one or more subfolders, recursively performing (i), (ii), (iii), and (iv) on each of the one or more subfolders of the first search folder, to retrieve documents, if any, contained in the one or more subfolders. The system displays the identified documents to the user.

Abstract: A method is performed at a computing system having one or more processors and memory. The process generates a hierarchical set of folders for a collection of documents. Each folder specifies a rule/query (possibly empty) for identifying a subset of the collection of documents. Each folder also specifies a user-defined set (possibly empty) of individual documents from the collection of documents. In addition, each folder specifies a set (possible empty) of subfolders. The process receives user input to select a first folder of the set of folders, and generates a responsive result set. The result set includes documents that satisfy the specified rule for the first folder, documents from the user-defined set of documents for the first folder, and documents recursively contained in subfolders of the first folder. The process then displays the result set to the user.

Abstract: Polypeptides are disclosed which inhibit the binding of the C5a chemotaxin to polymorphonuclear leukocytes by cleaving a six amino acid peptide from the carboxy-terminus of the C5a chemotaxin. The polypeptides can be isolated from virulent strains of group A streptococci, s. pyogenes, by enzymatic or detergent extraction.