Abstract: Needle-free injection devices and drug delivery systems are disclosed. The needle-free injection devices may include a drug delivery system, a power source, an activation system, and a disabling element. The drug delivery system may include a needle-free syringe and a drug storage system. The needle-free syringe may include a plunger slidably disposed within an injection chamber. The injection chamber may include an injection orifice, and the plunger may be configured to expel a volume of fluid from the injection chamber through the injection orifice. The drug storage system may include a storage chamber and an outlet. The drug storage system may be frangibly connected to the needle-free syringe with the outlet proximate to and fluidly connected with the injection orifice. The drug storage system may be configured to inject a fluid from the storage chamber through the outlet, through the injection orifice, and into the injection chamber.

Abstract: A nozzle assembly for a needle-free injection device. The nozzle assembly includes a nozzle body including an injectate chamber and one or more outlet orifices and a plunger configured to move through the injectate chamber toward the one or more outlet orifices. In some embodiments, the plunger includes a first portion and a second portion removably joined by a frangible region. In some embodiments, the plunger includes extensions configured to couple the plunger to a drive assembly of a needle-free injection device.

Abstract: A nozzle assembly for a needle-free injection device. The nozzle assembly includes a nozzle body including an injectate chamber and one or more outlet orifices and a plunger configured to move through the injectate chamber toward the one or more outlet orifices. In some embodiments, the plunger includes a first portion and a second portion removably joined by a frangible region. In some embodiments, the plunger includes extensions configured to couple the plunger to a drive assembly of a needle-free injection device.

Abstract: Needle-free hypodermic jet injection devices having an actuation system to effect an injection from a drug delivery system. The actuation system includes an injection force assembly adapted to transmit a driving force to the drug delivery system. The actuation system further includes a trigger assembly adapted to alter the actuation system between a plurality of configurations including a fired configuration in which the injection force assembly transmits a driving force to the drug delivery system. In some embodiments, the device has a recoil restriction system including a restriction member adapted to couple the recoil restriction system to the trigger assembly and a recoil member coupled to the injection force assembly and movable relative to the restriction member. The restriction member limits movement of the recoil member once the recoil member moves a predetermined distance relative to the restriction member.

Abstract: Needle-free hypodermic jet injection devices having an actuation system to effect an injection from a drug delivery system. The actuation system includes an injection force assembly adapted to transmit a driving force to the drug delivery system. The actuation system further includes a trigger assembly adapted to alter the actuation system between a plurality of configurations including a fired configuration in which the injection force assembly transmits a driving force to the drug delivery system. In some embodiments, the device has a recoil restriction system including a restriction member adapted to couple the recoil restriction system to the trigger assembly and a recoil member coupled to the injection force assembly and movable relative to the restriction member. The restriction member limits movement of the recoil member once the recoil member moves a predetermined distance relative to the restriction member.

Abstract: A nozzle assembly for a needle-free injection device. The nozzle assembly includes a nozzle body including an injectate chamber and one or more outlet orifices and a plunger configured to move through the injectate chamber toward the one or more outlet orifices. In some embodiments, the plunger includes a first portion and a second portion removably joined by a frangible region. In some embodiments, the plunger includes extensions configured to couple the plunger to a drive assembly of a needle-free injection device.

Abstract: Needle-free injection devices having a body, an actuation system, and a delivery system including a drive assembly and configured to receive a nozzle assembly. In some embodiments, the drive assembly includes a spring and a support member configured to restrict movement of the spring in a direction non-parallel to a central axis of the spring. In some embodiments, the drive assembly includes a transmission assembly configured to couple a drive source with the actuation system upon engagement of a nozzle assembly with the drive assembly. In some embodiments, the body is configured to acoustically seal an interface between the delivery system and the actuation system. In some embodiments, the body includes a gripping member selectively extendable from the body.

Abstract: Needle-free injection devices and drug delivery systems are disclosed. The needle-free injection devices may include a drug delivery system, a power source, an activation system, and a disabling element. The drug delivery system may include a needle-free syringe and a drug storage system. The needle-free syringe may include a plunger slidably disposed within an injection chamber. The injection chamber may include an injection orifice, and the plunger may be configured to expel a volume of fluid from the injection chamber through the injection orifice. The drug storage system may include a storage chamber and an outlet. The drug storage system may be frangibly connected to the needle-free syringe with the outlet proximate to and fluidly connected with the injection orifice. The drug storage system may be configured to inject a fluid from the storage chamber through the outlet, through the injection orifice, and into the injection chamber.

Abstract: Needle-free hypodermic jet injection devices having an actuation system to effect an injection from a drug delivery system. The actuation system includes an injection force assembly adapted to transmit a driving force to the drug delivery system. The actuation system further includes a trigger assembly adapted to alter the actuation system between a plurality of configurations including a fired configuration in which the injection force assembly transmits a driving force to the drug delivery system. In some embodiments, the device has a recoil restriction system including a restriction member adapted to couple the recoil restriction system to the trigger assembly and a recoil member coupled to the injection force assembly and movable relative to the restriction member. The restriction member limits movement of the recoil member once the recoil member moves a predetermined distance relative to the restriction member.

Abstract: Needle-free injection devices having a drive assembly to provide an operative force to effect an injection and a dosing assembly to prepare the device for a subsequent injection. In some embodiments, the dosing assembly is configured to transfer injectate from an injectate source to the injectate assembly. In some embodiments, a portion of energy available to the drive assembly urges the injectate towards the injectate assembly. In some embodiments, the device includes a nozzle assembly having one or more ports.

Abstract: A needle-free injection device is described. The injection device includes a user-grippable housing and a syringe assembly movably secured to the housing. The syringe assembly is configured to expel injectable fluid out of a nozzle upon application of pressurized gas to the syringe assembly. The injection device also includes a pressurized gas delivery mechanism disposed within the housing and configured to selectively apply pressurized gas to the syringe assembly. The pressurized gas delivery mechanism is at least partly actuated by pressing the nozzle onto an injection site so that the syringe assembly moves relative to the housing.

Abstract: A needle-free injection device is described. The injection device typically includes a system for providing directed and pre-selected pressure and a nozzle with an orifice for defining a stream of fluid that is directed toward the skin of a patient against which a front end of the nozzle is positioned. The device also normally includes an engagement system that can selectively engage the nozzle with the pressurizing system so that the nozzle can be mounted to the pressurizing system to receive pressure for injection and so that after injection the nozzle can be removed and replaced for each new use of the device.

Abstract: A needle-free injection device is described. The injection device includes a user-grippable housing and a syringe assembly movably secured to the housing. The syringe assembly is configured to expel injectable fluid out of a nozzle upon application of pressurized gas to the syringe assembly. The injection device also includes a pressurized gas delivery mechanism disposed within the housing and configured to selectively apply pressurized gas to the syringe assembly. The pressurized gas delivery mechanism is at least partly actuated by pressing the nozzle onto an injection site so that the syringe assembly moves relative to the housing.

Abstract: A needle-free injection device is described. The injection device typically includes a system for providing directed and pre-selected pressure and a nozzle with an orifice for defining a stream of fluid that is directed toward the skin of a patient against which a front end of the nozzle is positioned. The device also normally includes an engagement system that can selectively engage the nozzle with the pressurizing system so that the nozzle can be mounted to the pressurizing system to receive pressure for injection and so that after injection the nozzle can be removed and replaced for each new use of the device.

Abstract: A gas-powered, durable, needle-free hypodermic jet injection device includes a hand-held injector which carries a disposable injection cartridge with a volume of liquid medication to be injected in the form of a high velocity jet capable of penetrating the skin without the use of a hypodermic needle. The injection device provides an injection orifice, and an injection piston. Forceful movement of the injection piston caused by high pressure gas causes a high velocity injection jet of liquid medication to be expelled from the injection cylinder via the injection orifice. The injection device includes features which improve its safety, and also which improve its ease of manufacture, its durability, and its cost effectiveness.

Abstract: A gas-powered, durable, needle-free hypodermic jet injection device includes a hand-held injector which carries a disposable injection cartridge with a volume of liquid medication to be injected in the form of a high velocity jet capable of penetrating the skin without the use of a hypodermic needle. The injection device provides an injection orifice, and an injection piston. Forceful movement of the injection piston caused by high pressure gas causes a high velocity injection jet of liquid medication to be expelled from the injection cylinder via the injection orifice. The injection device includes features which improve its safety, and also which improve its ease of manufacture, its durability, and its cost effectiveness.

Abstract: This invention relates to an apparatus and method for plugging holes in an acetabular shell component. The apparatus includes an acetabular shell component having an inner concave surface and an outer convex surface with at least a first selectively pluggable hole passing therethrough. The first selectively pluggable hole being defined by at least a cylindrical threaded sidewall. The apparatus further includes a plug having a tapered threaded sidewall. The cylindrical threaded sidewall of the first selectively pluggable hole threadably receives the tapered threaded sidewall of the plug to create an interference fit. This interference fit substantially seals the first selectively pluggable hole to minimize migration of debris through the first selectively pluggable hole.

Abstract: A two piece construction disposable carpal tunnel ligament tome is provided. In a preferred embodiment the tome has a handle, stem, cutting head with two forward extending and parallel spaced upper and lower forks. The handle, stem, cutting head and forks are injection molded as one plastic piece. Mounted in the cutting head is a blade fabricated from flat stock metal with a forward facing cutting edge concealed by the forks. Extending forward from the blade are upper and lower fork reinforcement members. The fork reinforcements are encapsulated by the molded upper and lower forks. The inventive carpal tunnel ligament tome provides very rigid forks, yet does not require the extensive machining required by tomes with metal forks. Since the blade and fork reinforcement can be fabricated from a flat stock material, fabrication costs can be lowered with extremely high performance of the tome being maintained.

Abstract: A glenoid component for use in shoulder arthroplasty which is adapted to be implanted into a scapula and engaged by a head of a humeral component. The glenoid component includes a body having a first articulating surface and second textured medial surface opposite to the first articulating surface. The first articulating surface is adapted to be engaged by the head of the humeral component and the second textured medial surface is adapted to be secured to the scapula. A plurality of circular base members extends from the second textured medial surface and provides a circular base pad having a first diameter. A plurality of cylindrical pegs each have a first end adapted to engage a cavity formed in the scapula and a second end extending from one of the circular base members. Each of the cylindrical pegs is partially defined by a sidewall having a second diameter such that the first diameter of the cylindrical base pads is larger than the second diameter of the cylindrical pegs to increase peg shear strength.

Abstract: A vertical foldable wheelchair (10) having a pair of side frame assemblies (11, 11') each including frame members coupled together for selective movement of the side frame assemblies (11, 11') between a vertically extended deployed condition and a relatively vertically compact collapsed condition. The frame members are coupled together to provide a bi-stable, over-center, linkage assembly (13, 13') which is movable between and biased toward both of: (i) a first stable position on one side of a linkage assembly centerline when the side frame assemblies (11, 11') are in the deployed condition; and (ii) a second stable position on an opposite side of the centerline when the side frame assemblies (11, 11') are in the collapsed condition.