Abstract: Provided herein are methods of monitoring for the production of select antibodies in a non-human animal, comprising (a) immunizing a non-human animal with an immunogen; (b) obtaining a blood sample comprising antibody secreting cells (ASCs) from said non-human animal; and (c) individually assaying ASCs present in the blood sample, or a fraction thereof, for the production of select antibodies. Methods of guiding antibody production in a non-human animal for the production of select antibodies are also provided. In exemplary embodiments, the method comprises performing a cycle of (a) to (c), as above, and repeating the cycle when the percentage of ASCs producing select antibodies is below a threshold. In various aspects, the cycle is repeated until the percentage of ASCs producing select antibodies is at or above a threshold. Single cell assays are further provided herein.

Abstract: A method and system creates an interactive multimedia document that incorporates references to multimedia files that support a particular logical step or argument presented within the document. The method and system utilizes several modules including a builder module and a presenter module. The references are configured to determine, upon selection, a visual format and a relevant portion of the multimedia file to be displayed. Thus, only one copy of the multimedia file needs to be incorporated into the document. The multimedia files include text documents, portable document files, PowerPoint® presentations, audio files, video files, voice narrated graphics, and other types of files. In some embodiments, the interactive multimedia document is a legal brief and the multimedia files include depositions, supporting case law, evidence, and other materials.

Abstract: A method and system creates an interactive multimedia document that incorporates references to multimedia files that support a particular logical step or argument presented within the document. The method and system utilizes several modules including a builder module and a presenter module. The references are configured to determine, upon selection, a visual format and a relevant portion of the multimedia file to be displayed. Thus, only one copy of the multimedia file needs to be incorporated into the document. The multimedia files include text documents, portable document files, PowerPoint® presentations, audio files, video files, voice narrated graphics, and other types of files. In some embodiments, the interactive multimedia document is a legal brief and the multimedia files include depositions, supporting case law, evidence, and other materials.

Abstract: A method and system creates an interactive multimedia document that incorporates references to multimedia files that support a particular logical step or argument presented within the document. The method and system utilizes several modules including a builder module and a presenter module. The references are configured to determine, upon selection, a visual format and a relevant portion of the multimedia file to be displayed. Thus, only one copy of the multimedia file needs to be incorporated into the document. The multimedia files include text documents, portable document files, PowerPoint® presentations, audio files, video files, voice narrated graphics, and other types of files. In some embodiments, the interactive multimedia document is a legal brief and the multimedia files include depositions, supporting case law, evidence, and other materials.

Abstract: A method and system creates an interactive multimedia document that incorporates references to multimedia files that support a particular logical step or argument presented within the document. The method and system utilizes several modules including a builder module and a presenter module. The references are configured to determine, upon selection, a visual format and a relevant portion of the multimedia file to be displayed. Thus, only one copy of the multimedia file needs to be incorporated into the document. The multimedia files include text documents, portable document files, PowerPoint® presentations, audio files, video files, voice narrated graphics, and other types of files. In some embodiments, the interactive multimedia document is a legal brief and the multimedia files include depositions, supporting case law, evidence, and other materials.