Abstract: Provided herein is a method of characterising a target polynucleotide as it moves with respect to a nanopore using a motor protein. Also provided are polynucleotide adapters and kits comprising such adapters. The methods, kits and adapters find use in characterising polynucleotides, for example in sequencing.

Abstract: A controller for a switching regulator includes an error amplifier configured to receive a feedback voltage indicative of the regulated output voltage and a reference voltage, and to generate an error signal indicative of the difference between the feedback voltage and the reference voltage; a loop calculator configured to generate an output signal in response to the error signal, the output signal being used by the switching regulator to generate the regulated output voltage having a voltage value related to the reference voltage; and an output voltage adjust circuit configured to receive a sense current signal indicative of a current flowing through the load and to generate a voltage adjust signal in response to the sense current signal, the voltage adjust signal being applied to generate the reference voltage relative to a predetermined set voltage.

Abstract: A controller for a switching regulator includes an error amplifier configured to receive a feedback voltage indicative of the regulated output voltage and a reference voltage, and to generate an error signal indicative of the difference between the feedback voltage and the reference voltage; a loop calculator configured to generate an output signal in response to the error signal, the output signal being used by the switching regulator to generate the regulated output voltage having a voltage value related to the reference voltage; and an output voltage adjust circuit configured to receive a sense current signal indicative of a current flowing through the load and to generate a voltage adjust signal in response to the sense current signal, the voltage adjust signal being applied to generate the reference voltage relative to a predetermined set voltage.

Abstract: A suspension system for a differential-pressure touch sensitive panel suspended over force sensors, for use in either fixed or mobile devices such as point of sales terminals, kiosks, laptops, monitors, PDAs, cell phones, UMPCs and more. In one embodiment, each side of the lens is encircled and supported by a looped string, monofilament or flexible wire, which is then looped around the back cover or base plate, forming a figure-8. The figure 8-loops bring the lens into a fixed state in the xy-plane without the addition of any friction causing physical contact. Other alternative implementations include continuous suspensions, bender suspensions and 3-dimensional force suspensions. Moreover, the present invention proposes the use of a flexible padding under the force sensors to allow the sensors to be slightly preloaded, which reduces the dependency on extremely tight mechanical tolerances.

Abstract: A suspension system for a differential-pressure touch sensitive panel suspended over force sensors, for use in either fixed or mobile devices such as point of sales terminals, kiosks, laptops, monitors, PDAs, cell phones, UMPCs and more. In one embodiment, each side of the lens is encircled and supported by a looped string, monofilament or flexible wire, which is then looped around the back cover or base plate, forming a figure-8. The figure 8-loops bring the lens into a fixed state in the xy-plane without the addition of any friction causing physical contact. Other alternative implementations include continuous suspensions, bender suspensions and 3-dimensional force suspensions. Moreover, the present invention proposes the use of a flexible padding under the force sensors to allow the sensors to be slightly preloaded, which reduces the dependency on extremely tight mechanical tolerances.

Abstract: An electromagnet for use in MRI apparatus comprising an annular vessel inside which annular windings energizable to produce a magnetic field are contained together with iron components, hereinafter termed cold iron, which components are mechanically anchored with respect to the windings, and iron shim rings positioned externally of the vessel within its annular bore, hereinafter termed warm iron, the size and relative position of the shim rings being chosen so that instability of the magnetic field introduced by one shim ring, due to vibration or temperature changes, is substantially compensated for by an equal and opposite effect produced by one or more other shim rings.