Patents by Inventor Daniel Ehrlich
Daniel Ehrlich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240084043Abstract: Provided herein are methods of treating eye disorders by administering an anti-VEGF antibody and/or conjugate to a subject having an eye disorder. The anti-VEGF antibody of the present disclosure may be an anti-VEGF antibody conjugate that includes a polymeric moiety that extends the half-life/effectiveness/properties of the antibody when administered to a subject. A method of the present disclosure includes administering one or more doses of an anti-VEGF antibody conjugate to a subject (e.g., human or other mammalian patient) in need of treating an eye disorder, where the anti-VEGF antibody conjugate may be administered less frequently than a standard anti-VEGF therapy to treat the eye disorder.Type: ApplicationFiled: November 8, 2023Publication date: March 14, 2024Inventors: Jason Ehrlich, Pablo Velazquez-Martin, Joel Naor, Daniel Victor Perlroth, Hong Liang
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Patent number: 11912784Abstract: Provided herein are methods of treating eye disorders by administering an anti-VEGF antibody and/or conjugate to a subject having an eye disorder. The anti-VEGF antibody of the present disclosure may be an anti-VEGF antibody conjugate that includes a polymeric moiety that extends the half-life/effectiveness/properties of the antibody when administered to a subject. A method of the present disclosure includes administering one or more doses of an anti-VEGF antibody conjugate to a subject (e.g., human or other mammalian patient) in need of treating an eye disorder, where the anti-VEGF antibody conjugate may be administered less frequently than a standard anti-VEGF therapy to treat the eye disorder.Type: GrantFiled: October 9, 2020Date of Patent: February 27, 2024Assignee: Kodiak Sciences Inc.Inventors: Jason Ehrlich, Pablo Velazquez-Martin, Joel Naor, Daniel Victor Perlroth, Hong Liang
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Publication number: 20130247995Abstract: Embodiments of the invention relate to systems, methods, and apparatuses for a control valve. In one embodiment, a valve can be provided. The valve can include a flow restrictor portion operable to generate a pressure drop in a fluid flow by viscous dissipation; a throttle portion operable to change a flow rate of the fluid; and a guard portion operable to separate the flow restrictor portion from the throttle portion.Type: ApplicationFiled: March 20, 2012Publication date: September 26, 2013Applicant: THE AEROSPACE CORPORATIONInventor: Daniel A. Ehrlich
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Patent number: 7491943Abstract: A method and apparatus for illuminating a subject with deep UV light and detecting 2-dimensional image information, e.g., a transmission image, fluorescence image, reflected light image, etc. The subject may be illuminated with a light pulse having a duration of 2 seconds or less and one or more components with a wavelength of between about 150 nm to about 300 nm. The light pulse may be arranged so as to minimize or eliminate any detrimental effect on the functioning of the subject, e.g., on a living cell. A concentration, mass, quantum yield, absorbance or other characteristics of one or more compounds in the subject may be determined based on one or more 2-dimensional images obtained of the subject. An illumination beam having left and right circularly polarized components may be generated, e.g., for circular dichroism analysis of a subject.Type: GrantFiled: January 13, 2006Date of Patent: February 17, 2009Assignees: Whitehead Institute for Biomedical Research, Massachusetts Institute of TechnologyInventors: Benjamin J. Zeskind, Paul Matsudaira, Daniel Ehrlich
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Patent number: 7335874Abstract: A method and apparatus for illuminating a subject with deep UV light and detecting 2-dimensional image information, e.g., a transmission image, fluorescence image, reflected light image, etc. The subject may be illuminated with a light pulse having a duration of 2 seconds or less and one or more components with a wavelength of between about 150 nm to about 300 nm. The light pulse may be arranged so as to minimize or eliminate any detrimental effect on the functioning of the subject, e.g., on a living cell. A concentration, mass, quantum yield, absorbance or other characteristics of one or more compounds in the subject may be determined based on one or more 2-dimensional images obtained of the subject. An illumination beam having left and right circularly polarized components may be generated, e.g., for circular dichroism analysis of a subject.Type: GrantFiled: January 13, 2006Date of Patent: February 26, 2008Assignees: Whitehead Institute for Biomedical Research, Massachusetts Institute of TechnologyInventors: Benjamin J. Zeskind, Paul Matsudaira, Daniel Ehrlich
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Publication number: 20060209408Abstract: A method and apparatus for illuminating a subject with deep UV light and detecting 2-dimensional image information, e.g., a transmission image, fluorescence image, reflected light image, etc. The subject may be illuminated with a light pulse having a duration of 2 seconds or less and one or more components with a wavelength of between about 150 nm to about 300 nm. The light pulse may be arranged so as to minimize or eliminate any detrimental effect on the functioning of the subject, e.g., on a living cell. A concentration, mass, quantum yield, absorbance or other characteristics of one or more compounds in the subject may be determined based on one or more 2-dimensional images obtained of the subject. An illumination beam having left and right circularly polarized components may be generated, e.g., for circular dichroism analysis of a subject.Type: ApplicationFiled: January 13, 2006Publication date: September 21, 2006Applicant: Whitehead Institute for Biomedical ResearchInventors: Benjamin Zeskind, Paul Matsudaira, Daniel Ehrlich
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Publication number: 20060188869Abstract: A method and apparatus for illuminating a subject with deep UV light and detecting 2-dimensional image information, e.g., a transmission image, fluorescence image, reflected light image, etc. The subject may be illuminated with a light pulse having a duration of 2 seconds or less and one or more components with a wavelength of between about 150 nm to about 300 nm. The light pulse may be arranged so as to minimize or eliminate any detrimental effect on the functioning of the subject, e.g., on a living cell. A concentration, mass, quantum yield, absorbance or other characteristics of one or more compounds in the subject may be determined based on one or more 2-dimensional images obtained of the subject. An illumination beam having left and right circularly polarized components may be generated, e.g., for circular dichroism analysis of a subject.Type: ApplicationFiled: January 13, 2006Publication date: August 24, 2006Applicant: Whitehead Institute for Biomedical ResearchInventors: Benjamin Zeskind, Paul Matsudaira, Daniel Ehrlich
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Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device
Publication number: 20060144706Abstract: A technique processes a sample of biomolecular analyte. The technique uses an apparatus having a support assembly that receives and supports a test module, a load assembly that loads the sample of biomolecular analyte onto the test module, an electrophoresis assembly that applies a current to the test module such that components within the sample separate by electrophoresis, and a controller that controls operations of the load assembly and the electrophoresis assembly. The load assembly and the electrophoresis assembly are coupled to the support assembly. The controller controls the operation of the load assembly in an automated manner. Preferably, the test module includes a dielectric plate member having an upper planar surface and a lower planar surface that is spaced apart from and coplanar with the upper planar surface. The dielectric plate member has at least one set of channels that includes an injection channel and a separation channel.Type: ApplicationFiled: December 13, 2005Publication date: July 6, 2006Inventors: Aram Adourian, Daniel Ehrlich, Lance Koutny, Paul Matsudaira, Dieter Schmalzing -
Publication number: 20060035289Abstract: The present invention is related to an affinity fluorescent protein (aFP) comprising a modified fluorescent protein or molecule which comprises a heterologous amino acid sequence, thereby introducing a ligand-activated protein binding site, wherein the modified fluorescent protein displays an altered spectral property when the binding site is engaged with ligand relative to the spectral property displayed when the binding site is not engaged by ligand.Type: ApplicationFiled: November 1, 2004Publication date: February 16, 2006Applicant: Whitehead Institute for Biomedical ResearchInventors: Paul Matsudaira, Daniel Ehrlich, Qiuhui Zhong, Yelena Freyzon
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Patent number: 5874011Abstract: Techniques and apparatus for the laser induced etching of a reactive material, or of a multilayer substrate or wafer comprising layers of materials of different etching characteristics and reactivities, are disclosed. Short wavelength laser radiation and control of the process ambient equalize etch rates of the layers of a multilayer substrate or wafer and allow high-resolution etching. A suppressant gas introduced into a halogen-containing ambient suppresses explosive reactions between the ambient and reactive materials or layers. For less reactive layers or materials, reduced-pressure air is a suitable ambient. The techniques and apparatus disclosed herein are particularly useful in the manufacture of magnetic data transfer heads.Type: GrantFiled: August 1, 1996Date of Patent: February 23, 1999Assignee: Revise, Inc.Inventor: Daniel Ehrlich
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Patent number: 5389196Abstract: A method for producing a three-dimensional object includes the steps of providing an interface plane within a chamber and generating a beam of radiant energy having varied levels of beam energy density. The beam is directed to selectively expose a pattern of address points on the interface plane to the beam of radiant energy for a limited duration. Conditions are established in the chamber to enable the beam to induce a micro-chemical reaction at the interface plane at a rate which serves to form a portion of the three-dimensional object. A significant feature of the invention is that the micro-chemical reaction is substantially binary with respect to the beam energy density. That is, the reaction is either substantially "on" or substantially "off.Type: GrantFiled: January 30, 1992Date of Patent: February 14, 1995Assignee: Massachusetts Institute of TechnologyInventors: Theodore M. Bloomstein, Daniel Ehrlich, Anita M. Flynn