Abstract: The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasome production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R1, R2, R3a, R3b and R4 are defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of a disease or disorder that is associated with NLRP3 inflammasome activity.

Abstract: An embodiment includes generating a query prompting a user to select from among a plurality of response options related to a first query set of objects. The embodiment also receives, responsive to the query, user input representative of a selected response option selected by the user from among the plurality of response options. The embodiment also calculates a plurality of weight values for respective ones of a plurality of similarity matrices based on the selected response option, where the plurality of similarity matrices include respective different sets of similarity values, each set of similarity values comprising similarity values representative of similarities of respective pairs of the plurality of objects. The embodiment stores a designated similarity matrix that is selected from among the plurality of similarity matrices based at least in part on a weight value from among the plurality of weight values assigned to the designated similarity matrix.

Abstract: Polymer composites including feldspar having improved processability and biodegradability without loss of strength or flexibility are described. The polymer composites can be moulded into disposable articles such as coffee capsules, cutlery, straws, drink stirrers, food trays, single-serve packaging, such as a cup, cap, container and/or lid, or any other single-use item.

Abstract: The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasome production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R1, R2, R3 and R4 are defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of a disease or disorder that is associated with NLRP3 inflammasome activity.

Abstract: A wearable cooling device that is designed to rapidly restore and/or maintain a user's thermal comfort is provided. The disclosed wearable cooling device is versatile and may be affixed to or in contact with (or close proximity to) a variety of locations on a user's body, e.g., wrist, neck and ankle, among others. The wearable cooling device utilizes a forced air device, e.g., a fan, that blows air onto a wetted piece of media, e.g., fabric, which is in direct contact with a high thermally conductive element, e.g., copper or aluminum. The high thermally conductive element may be in contact with a user's skin or with a user's outer clothing. The wetted media is situated between the forced air device and the high thermally conductive element. When the forced air device is activated, the exhaust air passes onto and around the wetted media, which in turn cools the high thermally conductive element. As a result, the high thermally conductive element cools down the user.

Abstract: A Heating, Ventilation, and Air Conditioning (HVAC) system that is configured to receive a refrigerant from a condenser at a fixed expansion device and a variable expansion device. The system is further configured to output a first portion of the refrigerant to a first downstream HVAC component at a fixed flow rate using the fixed expansion device. The system is further configured to apply a first force to a pin of the variable expansion device based on a sensed temperature. The system is further configured to apply a second force to a valve of the variable expansion device via the force applied to the pin and to output a second portion of the refrigerant to a second downstream HVAC component at a variable flow rate based on the second force using the valve of the variable expansion device.

Abstract: A three-dimensional printing system including at least one positioning mechanism, and at least one end effector movably connected to the at least one positioning mechanism. The at least one end effector includes at least one mixing head configured to dispense a material, and at least one subtractive tool configured to subtract at least a portion of the material such that a desired design is achieved.

Abstract: A communication system includes a traffic relay (TR) device for locating unmanned traffic in a controlled airspace. The TR device comprises one or more processors configured to perform the step of receive a status message from an unmanned aerial vehicle (UAV). The status message provides identification and location information of the UAV. The one or more processors are also configured to perform the step of generate a warning message for communication to at least one manned aerial vehicle (MAV) or a manned traffic manager (MTM) device that is communicatively connected to the at least one MAV. The warning message is based on a comparison of the location of the UAV to a designated airspace.

Abstract: A computer-implemented technique is described herein for assisting a user in advancing a task objective. The technique uses a suggestion-generating system (SGS) to provide one or more suggestions to a user in response to at least a last-submitted query provided by the user. The SGS may correspond to a classification-type or generative-type neural network. The SGS uses a machine-trained model that is trained using a multi-task training framework based on plural groups of training examples, which, in turn, are produced using different respective example-generating methods. One such example-generating method constructs a training example from queries in a search session. It operates by identifying the task-related intent the queries, and then identifying at least one sequence of queries in the search session that exhibits a coherent task-related intent. A training example is constructed based on queries in such a sequence.

Abstract: Described herein are antibodies or variants thereof that specifically bind to coronavirus antigens, such as SARS-CoV-2 antigens. The antibodies can be neutralizing antibodies. Also provided are methods of using the antibodies, including methods of treating a subject infected with SARS-CoV-2, and methods of diagnosing a subject infected with SARS-CoV-2.

Abstract: Systems and methods for adjusting a weight, center of gravity, and balance point of a firearm are disclosed. The systems and methods include a handguard, a weight configured to be attached to the handguard, and a firearm accessory configured to be adjustably secured about the weight.

Abstract: The invention concerns a polymer composite comprising: a. biodegradable polymer in an amount of 5-94.5% by weight of the overall weight; b. flour of pulse in an amount of at least 5% by weight of the overall weight; c. plasticizer in an amount from 5-50% w/w of component b); d. optional filler, and e. optional additive, wherein c) is a solid plasticizer with a melting temperature in the range of 70 to 210°. The invention also concerns a process for its preparation, an intermediate, and a solid article comprising the polymer composite.

Abstract: A system is disclosed to build and store a data model and queries for a graph database. In various embodiments, data defining one or more aspects of a data model associated with a graph database is received. A set of data that represents the data model is stored as a graph that includes one or more nodes to represent each of the following: data model metadata, one or more node labels comprising the graph database, one or more relationship types of the graph database, and one or more property definitions each associated with a property of at least one of a node label and a relationship type of the graph database.

Abstract: Techniques for generating pre-defined outbound messages in response to a first inbound message or a first outbound message in a configured interval of time, including prioritization over configured autoreply messages. Source or destination messages conforming to business rules are sent to accompany outbound messages in particular orders and under particular circumstances.

Abstract: A system is disclosed to build and store a data model and queries for a graph database. In various embodiments, data defining one or more aspects of a data model associated with a graph database is received. A set of data that represents the data model is stored as a graph that includes one or more nodes to represent each of the following: data model metadata, one or more node labels comprising the graph database, one or more relationship types of the graph database, and one or more property definitions each associated with a property of at least one of a node label and a relationship type of the graph database.

Abstract: The invention concerns a polymer composite comprising: a. polymer in an amount of 5-94.5% by weight of the overall weight; b. milled oilseed meal in an amount of at least 5% by weight of the overall weight; c. plasticizer in an amount from 5-50% w/w of component b); d. optional filler, and e. optional additive, wherein c) is a solid plasticizer with a melting temperature in the range of 70 to 210°. The invention also concerns a process for its preparation, an intermediate, and a solid article comprising the polymer composite.

Abstract: The invention concerns a polymer composite comprising: a. biodegradable polymer in an amount of 5-94.5% by weight of the overall weight; b. whole grain flour of cereal grass in an amount of at least 5% by weight of the overall weight; c. plasticizer in an amount from 5-50% w/w of component b); d. optional filler, and e. optional additive, wherein c) is a solid plasticizer with a melting temperature in the range of 70 to 210° . The invention also concerns a process for its preparation, an intermediate, and a solid article comprising the polymer composite.