Patents by Inventor Daniel Eugene Meyer
Daniel Eugene Meyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10740651Abstract: The present approach relates to the use of trained artificial neural networks, such as convolutional neural networks, to classify vascular structures, such as using a hierarchical classification scheme. In certain approaches, the artificial neural network is trained using training data that is all or partly derived from synthetic vascular representations.Type: GrantFiled: October 27, 2017Date of Patent: August 11, 2020Assignee: GENERAL ELECTRIC COMPANYInventors: Alberto Santamaria-Pang, Daniel Eugene Meyer, Michael Ernest Marino, Qing Li, Dmitry V. Dylov, Aritra Chowdhury
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Patent number: 10423820Abstract: The subject matter of the present disclosure generally relates to techniques for image analysis. In certain embodiments, various morphological or intensity-based features as well as different thresholding approaches may be used to segment the subpopulation of interest and classify object in the images.Type: GrantFiled: September 13, 2017Date of Patent: September 24, 2019Assignee: GENERAL ELECTRIC COMPANYInventors: Alberto Santamaria-Pang, Qing Li, Yunxia Sui, Dmitry Vladimirovich Dylov, Christopher James Sevinsky, Michael E. Marino, Michael J. Gerdes, Daniel Eugene Meyer, Fiona Ginty, Anup Sood
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Publication number: 20190080146Abstract: The subject matter of the present disclosure generally relates to techniques for image analysis. In certain embodiments, various morphological or intensity-based features as well as different thresholding approaches may be used to segment the subpopulation of interest and classify object in the images.Type: ApplicationFiled: September 13, 2017Publication date: March 14, 2019Inventors: Alberto Santamaria-Pang, Qing Li, Yunxia Sui, Dmitry Vladimirovich Dylov, Christopher James Sevinsky, Michael E. Marino, Michael J. Gerdes, Daniel Eugene Meyer, Fiona Ginty, Anup Sood
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Publication number: 20190001002Abstract: Design and use of an administered drug in the form of a nanoparticle or molecule is described. In certain examples, the nanoparticle has a core and a shell surrounding the core. The core may be configured or designed to provide useful X-ray attenuating properties, gamma ray emission properties, magnetic properties, or therapeutic effects. In certain aspects, the nanoparticle or molecule is sized so as to either distribute from or remain in the blood pool, while still being eliminated by the kidneys.Type: ApplicationFiled: July 3, 2018Publication date: January 3, 2019Inventors: Paul Francis Fitzgerald, Michael Ernest Marino, Peter Michael Edic, Daniel Eugene Meyer, Peter J. Bonitatibus, JR., Robert Edgar Colborn, Benjamin Ming-Yueh Yeh
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Publication number: 20190001001Abstract: Design and use of an administered drug in the form of a nanoparticle or molecule is described. In certain examples, the nanoparticle has a core and a shell surrounding the core. The core may be configured or designed to provide useful X-ray attenuating properties, gamma ray emission properties, magnetic properties, or therapeutic effects. In certain aspects, the nanoparticle or molecule is sized so as to either distribute from or remain in the blood pool, while still being eliminated by the kidneys.Type: ApplicationFiled: July 3, 2017Publication date: January 3, 2019Inventors: Paul Francis Fitzgerald, Michael Ernest Marino, Peter Michael Edic, Daniel Eugene Meyer, Peter J. Bonitatibus, Jr., Robert Edgar Colborn, Benjamin Ming-Yueh Yeh
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Publication number: 20180121760Abstract: The present approach relates to the use of trained artificial neural networks, such as convolutional neural networks, to classify vascular structures, such as using a hierarchical classification scheme. In certain approaches, the artificial neural network is trained using training data that is all or partly derived from synthetic vascular representations.Type: ApplicationFiled: October 27, 2017Publication date: May 3, 2018Inventors: Alberto Santamaria-Pang, Daniel Eugene Meyer, Michael Ernest Marino, Qing Li, Dmitry V. Dylov, Aritra Chowdhury
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Patent number: 9846206Abstract: Magnetic material imaging (MMI) system including first and second sets of field-generating coils. Each of the field-generating coils of the first and second sets has an elongated segment that extends along an imaging axis of the medical imaging system. The imaging axis extends through a region-of-interest (ROI) of an object. The elongated segments of the first set of field-generating coils are positioned opposite the elongated segments of the second set of field-generating coils and the ROI is located between the first and second sets of field-generating coils. The MMI system also includes a coil-control module configured to control a flow of current through the first and second sets of field-generating coils to generate a selection field and to generate a drive field. The selection and drive fields combine to form a movable 1D field free region (FFR) that extends through the ROI.Type: GrantFiled: August 19, 2013Date of Patent: December 19, 2017Assignee: General Electric CompanyInventors: Dominic Michael Graziani, Thomas Kwok-Fah Foo, Luca Marinelli, Daniel Eugene Meyer, Bruce Allan Hay
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Patent number: 9474810Abstract: The present application discloses nanoparticles, particularly nanoparticles of superparamagnetic iron oxide, which find utility in iron therapy and diagnostic imaging such as magnetic resonance (MR). The disclosed nanoparticles have been treated with an ?-hydroxyphosphonic acid conjugate containing polyethylene glycol as a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are polyethylene oxide-based polymers and have a molecular weight greater than 5,000 dalton and less than or equal to about 30,000 daltons. Surprisingly, these nanoparticles have a more rapid and complete processing in liver of retained nanoparticles when compared to similar nanoparticles in which the PEG-based hydrophilic moiety has a molecular weight less than 5,000.Type: GrantFiled: March 2, 2012Date of Patent: October 25, 2016Assignee: General Electric CompanyInventors: Bruce Allan Hay, Daniel Eugene Meyer, Brian Christopher Bales, Michael Todd Luttrell
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Patent number: 9251937Abstract: A method of sterilizing a nanoparticle preparation at a high temperature is provided. A plurality of nanoparticles are purified to form the preparation, wherein the nanoparticles comprise at least a core and a shell and the shell comprises one or more ligand species attached to the core. The nanoparticle preparation is made by a purified nanoparticle composition, a carrier fluid and an excess of the one or more ligand species not attached to the core. The ligand species attached to the core and the excess ligand species added after purification are structurally identical. The nanoparticle preparation provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.Type: GrantFiled: June 29, 2012Date of Patent: February 2, 2016Assignee: General Electric CompanyInventors: Brian Christopher Bales, Brian James Grimmond, Daniel Eugene Meyer, Bruce Allan Hay, Michael Todd Luttrell
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Publication number: 20140159712Abstract: Magnetic material imaging (MMI) system including first and second sets of field-generating coils. Each of the field-generating coils of the first and second sets has an elongated segment that extends along an imaging axis of the medical imaging system. The imaging axis extends through a region-of-interest (ROI) of an object. The elongated segments of the first set of field-generating coils are positioned opposite the elongated segments of the second set of field-generating coils and the ROI is located between the first and second sets of field-generating coils. The MMI system also includes a coil-control module configured to control a flow of current through the first and second sets of field-generating coils to generate a selection field and to generate a drive field. The selection and drive fields combine to form a movable 1D field free region (FFR) that extends through the ROI.Type: ApplicationFiled: August 19, 2013Publication date: June 12, 2014Applicant: General Electric CompanyInventors: Dominic Michael Graziani, Thomas Kwok-Fah Foo, Luca Marinelli, Daniel Eugene Meyer, Bruce Allen Hay
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Publication number: 20140003997Abstract: A method of sterilizing a nanoparticle preparation at a high temperature is provided. A plurality of nanoparticles are purified to form the preparation, wherein the nanoparticles comprise at least a core and a shell and the shell comprises one or more ligand species attached to the core. The nanoparticle preparation is made by a purified nanoparticle composition, a carrier fluid and an excess of the one or more ligand species not attached to the core. The ligand species attached to the core and the excess ligand species added after purification are structurally identical. The nanoparticle preparation provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.Type: ApplicationFiled: June 29, 2012Publication date: January 2, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Brian Christopher Bales, Brian James Grimmond, Daniel Eugene Meyer, Bruce Allan Hay, Michael Todd Luttrell
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Publication number: 20130230463Abstract: The present application discloses nanoparticles, particularly nanoparticles of superparamagnetic iron oxide, which find utility in iron therapy and diagnostic imaging such as magnetic resonance (MR). The disclosed nanoparticles have been treated with an ?-hydroxyphosphonic acid conjugate containing polyethylene glycol as a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are polyethylene oxide-based polymers and have a molecular weight greater than 5,000 dalton and less than or equal to about 30,000 daltons. Surprisingly, these nanoparticles have a more rapid and complete processing in liver of retained nanoparticles when compared to similar nanoparticles in which the PEG-based hydrophilic moiety has a molecular weight less than 5,000.Type: ApplicationFiled: March 2, 2012Publication date: September 5, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Bruce Allan HAY, Daniel Eugene MEYER, Brian Christopher BALES, Michael Todd LUTTRELL
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Patent number: 8246932Abstract: Composition of non-radioactive traceable metal isotope-enriched nanoparticles, and methods of their use for determining in-vivo biodistribution are provided. The methods comprise the steps of: (a) introducing the nanoparticles into the biological material, wherein the nanoparticles comprise at least one inorganic core, and the inorganic core comprises at least two metal isotopes in a predetermined ratio; wherein at least one metal isotope is enriched non-radioactive traceable metal isotope and (b) determining the distribution of the nanoparticles in the biological material based on the predetermined ratio of the metal isotopes.Type: GrantFiled: March 28, 2008Date of Patent: August 21, 2012Assignee: General Electric CompanyInventors: Peter John Bonitatibus, Jr., Amit Mohan Kulkarni, Andrew Soliz Torres, Ying Zhou, Chiaki Treynor, Daniel Eugene Meyer
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Publication number: 20100189643Abstract: The present invention provides conjugate compounds comprising (a) an active compound; (b) optionally, but in some embodiments preferably, an affinity binding agent; and (c) a block copolymer, the block copolymer comprising: (i) a first elastin-like polypeptide having a first Tt and (U) a second elastin-like polypeptide having a second Tt greater than the first Tt. Method for the targeted delivering of an active compound in vivo to a selected region within a subject with such agents are also described.Type: ApplicationFiled: July 17, 2007Publication date: July 29, 2010Applicant: DUKE UNIVERSITYInventors: Ashutosh Chilkoti, Matthew Robert Dreher, Daniel Eugene Meyer
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Publication number: 20090246143Abstract: Composition of non-radioactive traceable metal isotope-enriched nanoparticles, and methods of their use for determining in-vivo biodistribution are provided. The methods comprise the steps of: (a) introducing the nanoparticles into the biological material, wherein the nanoparticles comprise at least one inorganic core, and the inorganic core comprises at least two metal isotopes in a predetermined ratio; wherein at least one metal isotope is enriched non-radioactive traceable metal isotope and (b) determining the distribution of the nanoparticles in the biological material based on the predetermined ratio of the metal isotopes.Type: ApplicationFiled: March 28, 2008Publication date: October 1, 2009Applicant: GENERAL ELECTRIC COMPANYInventors: Peter John Bonitatibus, JR., Amit Mohan Kulkarni, Andrew Soliz Torres, Ying Zhou, Chiaki Treynor, Daniel Eugene Meyer