Patents by Inventor Daniel F. Milano

Daniel F. Milano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of preparing cell-binding agent-drug conjugates
    Patent number: 11833214
    Abstract: The present invention provides methods of preparing a cell-binding agent-cytotoxic agent conjugate comprising a cell-binding agent (CysCBA) having one or more unpaired cysteine residues covalently linked to a cytotoxic agent. Also provided are conjugates prepared by the methods described herein and pharmaceutical composition and methods of use thereof.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: December 5, 2023
    Assignee: IMMUNOGEN, INC.
    Inventors: Scott A Hilderbrand, Daniel F. Milano
  • METHODS FOR ANTIBODY DRUG CONJUGATION, PURIFICATION, AND FORMULATION
    Publication number: 20220267371
    Abstract: Methods of producing, purifying, and formulating antibody drug conjugates (ADCs) are provided herein. The methods use continuous conjugation processes, single-pass tangential flow filtration, countercurrent diafiltration, and/or in-line process automation technologies. The methods decrease process times and costs and improve product consistency.
    Type: Application
    Filed: February 8, 2022
    Publication date: August 25, 2022
    Inventors: Daniel F. MILANO, Michael R. REARDON, Richard A. SILVA, Benjamin M. HUTCHINS, Robert W. HERBST
  • Methods for antibody drug conjugation, purification, and formulation
    Patent number: 11274121
    Abstract: Methods of producing, purifying, and formulating antibody drug conjugates (ADCs) are provided herein. The methods use continuous conjugation processes, single-pass tangential flow filtration, countercurrent diafiltration, and/or in-line process automation technologies. The methods decrease process times and costs and improve product consistency.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: March 15, 2022
    Assignee: ImmunoGen, Inc.
    Inventors: Daniel F. Milano, Michael R. Reardon, Richard A. Silva, Benjamin M. Hutchins, Robert W. Herbst
  • METHODS OF PREPARING CELL-BINDING AGENT-DRUG CONJUGATES
    Publication number: 20200405874
    Abstract: The present invention provides methods of preparing a cell-binding agent-cytotoxic agent conjugate comprising a cell-binding agent (CysCBA) having one or more unpaired cysteine residues covalently linked to a cytotoxic agent. Also provided are conjugates prepared by the methods described herein and pharmaceutical composition and methods of use thereof.
    Type: Application
    Filed: March 20, 2020
    Publication date: December 31, 2020
    Inventors: Scott A. Hilderbrand, Daniel F. Milano
  • METHODS FOR ANTIBODY DRUG CONJUGATION, PURIFICATION, AND FORMULATION
    Publication number: 20190270769
    Abstract: Methods of producing, purifying, and formulating antibody drug conjugates (ADCs) are provided herein. The methods use continuous conjugation processes, single-pass tangential flow filtration, countercurrent diafiltration, and/or in-line process automation technologies. The methods decrease process times and costs and improve product consistency.
    Type: Application
    Filed: January 11, 2019
    Publication date: September 5, 2019
    Inventors: Daniel F. Milano, Michael R. Reardon, Richard A. Silva, Benjamin M. Hutchins, Robert W. Herbst