Abstract: A computer-implemented method for updating a surgical plan for placement of a joint implant is disclosed. The surgical plan is obtained, including an implant model, an implant size, and an initial value for each of a plurality of placement parameters. At least one knee performance equation is selected from a library based on the surgical plan information, wherein each knee performance equation relates an output response associated with a post-operative influence to the plurality of placement parameters. Each output response is calculated across a range of values for each of a subset of the plurality of placement parameters. A graphical representation of the output response across each range is displayed, and input related to a selected value for each placement parameter of the subset is received. The surgical plan is updated based on the selected values. Devices and non-transitory computer readable media for carrying out the method are also disclosed.

Abstract: A dual mode surgical imaging system for hybrid navigation. The imaging system can include a housing, a first camera configured for visual light, a second mono or stereo camera configured for IR, and a structured light generator configured to identify depth information. The first camera, the second camera, and the structured light generator are contained within the same housing and are coordinated to a single reference frame. The imaging system is configured to switch between use of the first camera or the second camera for markerless or marker-based navigation.

Abstract: A method for utilizing robotic surgical data for providing surgical training is disclosed. The method includes collecting, by a computing device, data related to a surgical procedure from one or more components of a computer-assisted surgical system. At least one of the one or more components is a robotically controlled surgical device. A graphical depiction representative of the surgical procedure is generated based on the collected data from the one or more components of the computer-assisted surgical system and one or more images providing a visual depiction of a patient's anatomy. A graphical user interface is output to a display device. The graphical user interface includes the graphical depiction of the surgical procedure and the collected data from the one or more components of the computer-assisted surgical system, to provide surgical training.

Abstract: Methods and system for characterizing ligament properties using elastography are disclosed. An ultrasound system capable of performing shear wave elasticity imaging and/or supersonic shear imaging may retrieve one or more images from a proposed surgical site. The one or more images may be provided to a surgical planning system that identifies one or more properties of ligaments proximate to the surgical site. Musculoskeletal simulations may be performed using the identified properties to preoperatively identify a surgical plan. Preoperative identification of a surgical plan may enable a surgeon to select from more fine-tuning options for a joint replacement than conventional systems.

Abstract: Disclosed are techniques to navigate soft tissue structures based on preoperative imaging for joint arthroplasty. Particular embodiments are useful for direct anterior approach total hip arthroplasty but may be applicable in other approaches and/or other surgical procedures. In some embodiments, the patient is imaged with MRI safe markers on the skin prior to surgery. These markers remain on the patient prior to and during surgery. The position of various muscular, venous, and nervous structures can be provided to the surgeon prior to making the incision, allowing him or her to navigate the soft tissue during dissection.

Abstract: Patient-specific guides for the Latarjet procedure, as well as surgical systems and methods of performing the Latarjet procedure to treat glenohumeral instability using such patient-specific guides are disclosed. A patient-specific coracoid guide and a patient-specific glenoid guide may be configured based on preoperatively generated three-dimensional models of the patient's shoulder anatomy. Guides may be configured for coracoid graft preparation and glenoid decortication. The coracoid graft may be placed in the desired position based on three-dimensional (3D) preoperative planning.

Abstract: A computer-implemented method for updating a surgical plan for placement of a joint implant is disclosed. The surgical plan is obtained, including an implant model, an implant size, and an initial value for each of a plurality of placement parameters. At least one knee performance equation is selected from a library based on the surgical plan information, wherein each knee performance equation relates an output response associated with a post-operative influence to the plurality of placement parameters. Each output response is calculated across a range of values for each of a subset of the plurality of placement parameters. A graphical representation of the output response across each range is displayed, and input related to a selected value for each placement parameter of the subset is received. The surgical plan is updated based on the selected values. Devices and non-transitory computer readable media for carrying out the method are also disclosed.

Abstract: Systems and methods for transmitting data in an operative setting are disclosed. A surgical system records data pertaining to a surgical procedure as the procedure is performed. The data is transferred to a portable electronic device, such as a cellular-enabled device, intermittently during the surgical procedure or after the surgical procedure is completed. The cellular-enabled device establishes a connection with a remote database that may be cloud-enabled for storage and analysis of the data.

Abstract: A method of generating a custom three-dimensional model of a bone is disclosed. A 2D image of the bone is obtained and an orientation and scale of the 2D image are aligned to a pre-determined coordinate system. Based on the 2D image, a representative bone is identified from a library of representative bones that are aligned to the pre-determined coordinate system. Based on the 2D image, an ideal view of a 3D model of the representative bone is selected. Modifications may be made to the 3D model by using additional representative bones from the library. A custom three-dimensional model of the bone is thereby generated.

Abstract: The present invention relates to a nucleic acid sequence comprising a binding site operably linked to a nucleotide of interest, wherein the binding site is capable of interacting with an RNA-binding protein such that translation of the nucleotide of interest is repressed in a viral vector production cell.

Abstract: Methods, non-transitory computer readable media, and surgical computing devices are disclosed herein for creating a three-dimensional (3D) model based on a plurality of received two-dimensional (2D) medical images containing patient anatomy and a tracking fiducial. Once the 2D images are received, a determination is made regarding any potential processing steps required to put the images into a standard view. Once the images are processed, a user may modify or adjust various factors. Using the size and orientation of the tracking fiducial a 3D virtual model is created based on a repository of known patient data, such as a bone atlas. The 3D virtual model can then be output to a display device and optionally used to facilitate a surgical procedure. The 3D virtual model of patient anatomy can advantageously be generated more quickly and using fewer resources with this technology.

Abstract: A nucleotide sequence encoding the RNA genome of a lentiviral vector, wherein the major splice donor site in the RNA genome of the lentiviral vector is inactivated, and wherein the cryptic splice donor site 3? to the major splice donor site is inactivated.

Abstract: The present disclosure provides a surgical navigation system that utilizes multimodal tracking along with low profile/small diameter bone pins to fix FBG sensors to a patient. With some embodiments, a multi-core fiber optic cable having both an infrared (IR) tracking sensor disposed at a known location in the multi-core fiber optic cable and FBGs. The FBGs can be used to locate the tip of the cable relative to the IR marker, where the tip of the cable is embedded in a bone, the location of the done can be determined.

Abstract: A surgical system and method for markerless intraoperative navigation is provided. The system can includes a structured light system that can be utilized to intraoperatively sense three-dimensional surface geometry. The computer system is configured to segment a depth image to obtain surface geometry data of an anatomical structure embodied within the depth image, register the surface geometry data of the anatomical structure to a model, and update the surgical plan according to the registered surface geometry data. The surgical system is an endoscopic surgical system.

Abstract: Methods and system for characterizing ligament properties using elastography are disclosed. An ultrasound system capable of performing shear wave elasticity imaging and/or supersonic shear imaging may retrieve one or more images from a proposed surgical site. The one or more images may be provided to a surgical planning system that identifies one or more properties of ligaments proximate to the surgical site. Musculoskeletal simulations may be performed using the identified properties to preoperatively identify a surgical plan. Preoperative identification of a surgical plan may enable a surgeon to select from more fine-tuning options for a joint replacement than conventional systems.

Abstract: The present invention provides a novel method for detecting replication competent virus in a test sample. The method comprises culturing and diluting a plurality of individual cell culture aliquots comprising virus-permissive cells and a portion of the test sample, followed by testing for the presence of replication competent virus. The method may be used in parallel with a positive control, which is also provided herein.

Abstract: Methods and systems of augmenting an implant intraoperatively and preparing a cone for revision surgical procedure are disclosed. A system includes a cutting device, a tracking and navigation system and a cutting system in operable communication with the cutting device and the tracking and navigation system. The cutting device includes a communication system, a cutting element, and a plurality of optical trackers. The tracking and navigation system is configured to detect a location of optical trackers. The control system is configured to cause the tracking and navigation system to detect the location of the cutting device, determine a revised shape for an implant cavity, cause the cutting device to cut the implant cavity to the revised shape, select a shape for a cone to be placed in the revised implant cavity, and machine the cone to the selected shape.

Abstract: Methods and system for characterizing ligament properties using elastography are disclosed. An ultrasound system capable of performing shear wave elasticity imaging and/or supersonic shear imaging may retrieve one or more images from a proposed surgical site. The one or more images may be provided to a surgical planning system that identifies one or more properties of ligaments proximate to the surgical site. Musculoskeletal simulations may be performed using the identified properties to preoperatively identify a surgical plan. Preoperative identification of a surgical plan may enable a surgeon to select from more fine-tuning options for a joint replacement than conventional systems.

Abstract: A cell for producing retroviral vectors comprising nucleic acid sequences encoding: i) gag-pol; ii) env; iii) the RNA genome of the retroviral vector; and iv) optionally rev, or a functional substitute thereof, wherein at least two nucleic acid sequences are located at the same genetic locus; and wherein the at least two nucleic acid sequences are in reverse and/or alternating orientations.

Abstract: The present invention provides novel methods for producing a viral vector. Corresponding viral vector production systems and uses are also provided.