Patents by Inventor Daniel Farley

Daniel Farley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240052366
    Abstract: A nucleotide sequence encoding the RNA genome of a lentiviral vector, wherein the major splice donor site in the RNA genome of the lentiviral vector is inactivated, and wherein the cryptic splice donor site 3? to the major splice donor site is inactivated.
    Type: Application
    Filed: February 4, 2021
    Publication date: February 15, 2024
    Inventors: Daniel Farley, Jordan Wright
  • Publication number: 20230414293
    Abstract: The present disclosure provides a surgical navigation system that utilizes multimodal tracking along with low profile/small diameter bone pins to fix FBG sensors to a patient. With some embodiments, a multi-core fiber optic cable having both an infrared (IR) tracking sensor disposed at a known location in the multi-core fiber optic cable and FBGs. The FBGs can be used to locate the tip of the cable relative to the IR marker, where the tip of the cable is embedded in a bone, the location of the done can be determined.
    Type: Application
    Filed: December 8, 2021
    Publication date: December 28, 2023
    Applicants: Smith & Nephew, Inc., Smith & Nephew Orthopaedics AG, Smith & Nephew Asia Pacific Pte. Limited
    Inventors: Daniel Farley, Darren J. Wilson, Branislav Jaramaz, Brett Bell
  • Publication number: 20230363831
    Abstract: A surgical system and method for markerless intraoperative navigation is provided. The system can includes a structured light system that can be utilized to intraoperatively sense three-dimensional surface geometry. The computer system is configured to segment a depth image to obtain surface geometry data of an anatomical structure embodied within the depth image, register the surface geometry data of the anatomical structure to a model, and update the surgical plan according to the registered surface geometry data. The surgical system is an endoscopic surgical system.
    Type: Application
    Filed: October 8, 2021
    Publication date: November 16, 2023
    Inventors: Branislav JARAMAZ, Daniel FARLEY, Darren J. WILSON, Carlos RODRIGUEZ, Constantinos NIKOU, Xuanye WANG
  • Publication number: 20230329796
    Abstract: Methods and system for characterizing ligament properties using elastography are disclosed. An ultrasound system capable of performing shear wave elasticity imaging and/or supersonic shear imaging may retrieve one or more images from a proposed surgical site. The one or more images may be provided to a surgical planning system that identifies one or more properties of ligaments proximate to the surgical site. Musculoskeletal simulations may be performed using the identified properties to preoperatively identify a surgical plan. Preoperative identification of a surgical plan may enable a surgeon to select from more fine-tuning options for a joint replacement than conventional systems.
    Type: Application
    Filed: June 28, 2023
    Publication date: October 19, 2023
    Inventors: Brian W. MCKINNON, Daniel FARLEY
  • Publication number: 20230279388
    Abstract: The present invention provides a novel method for detecting replication competent virus in a test sample. The method comprises culturing and diluting a plurality of individual cell culture aliquots comprising virus-permissive cells and a portion of the test sample, followed by testing for the presence of replication competent virus. The method may be used in parallel with a positive control, which is also provided herein.
    Type: Application
    Filed: March 8, 2021
    Publication date: September 7, 2023
    Inventors: Samuel James Stockdale, Rui Andre Saraiva Raposo, Daniel Farley, Nicholas George Clarkson
  • Publication number: 20230225799
    Abstract: Methods and systems of augmenting an implant intraoperatively and preparing a cone for revision surgical procedure are disclosed. A system includes a cutting device, a tracking and navigation system and a cutting system in operable communication with the cutting device and the tracking and navigation system. The cutting device includes a communication system, a cutting element, and a plurality of optical trackers. The tracking and navigation system is configured to detect a location of optical trackers. The control system is configured to cause the tracking and navigation system to detect the location of the cutting device, determine a revised shape for an implant cavity, cause the cutting device to cut the implant cavity to the revised shape, select a shape for a cone to be placed in the revised implant cavity, and machine the cone to the selected shape.
    Type: Application
    Filed: March 8, 2023
    Publication date: July 20, 2023
    Inventors: Roger Ryan DEES, JR., Sied W. JANNA, Daniel FARLEY, Branislav JARAMAZ
  • Patent number: 11701178
    Abstract: Methods and system for characterizing ligament properties using elastography are disclosed. An ultrasound system capable of performing shear wave elasticity imaging and/or supersonic shear imaging may retrieve one or more images from a proposed surgical site. The one or more images may be provided to a surgical planning system that identifies one or more properties of ligaments proximate to the surgical site. Musculoskeletal simulations may be performed using the identified properties to preoperatively identify a surgical plan. Preoperative identification of a surgical plan may enable a surgeon to select from more fine-tuning options for a joint replacement than conventional systems.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: July 18, 2023
    Assignees: Smith & Nephew, Inc., Smith & Nephew Orthopaedics AG, Smith & Nephew Asia Pacific Pte. Limited
    Inventors: Brian W. McKinnon, Daniel Farley
  • Publication number: 20230183742
    Abstract: The present invention provides novel methods for producing a viral vector. Corresponding viral vector production systems and uses are also provided.
    Type: Application
    Filed: May 14, 2021
    Publication date: June 15, 2023
    Inventors: Rui Andre Saraiva Raposo, Charles Moore-Kelly, Jordan Wright, Daniel Farley
  • Publication number: 20230183745
    Abstract: A cell for producing retroviral vectors comprising nucleic acid sequences encoding: i) gag-pol; ii) env; iii) the RNA genome of the retroviral vector; and iv) optionally rev, or a functional substitute thereof, wherein at least two nucleic acid sequences are located at the same genetic locus; and wherein the at least two nucleic acid sequences are in reverse and/or alternating orientations.
    Type: Application
    Filed: February 7, 2023
    Publication date: June 15, 2023
    Inventors: Hannah Stewart, Helen Maunder, Kyriacos Mitrophanous, Daniel Farley
  • Publication number: 20230172600
    Abstract: A tensioner tool for assessing joint laxity is disclosed. The tensioner tool comprises a pair of pivotally coupled arms, each arm comprising a proximal handle portion, a distal portion, and an insertion tip selectively coupled to the distal portion. The pair of arms pivot between a compressed configuration for insertion within the joint and an expanded configuration for distraction of the joint by applying a force to the handles, thus spreading the insertion tips. The tensioner tool also comprises a force sensor configured to measure the force applied to the handle portion and a positional sensor configured to measure a separation distance between the pair of arms. The tensioner tool also comprises a processor configured to calculate a distraction force at the insertion tips based on the measured force and to calculate a tip distance between the insertion tips based on the measured separation distance.
    Type: Application
    Filed: April 27, 2021
    Publication date: June 8, 2023
    Inventors: Samuel C. DUMPE, Branislav JARAMAZ, Ryan SHEEHAN, Brian W. MCKINNON, Daniel FARLEY
  • Patent number: 11622814
    Abstract: Methods and systems of augmenting an implant intraoperatively and preparing a cone for revision surgical procedure are disclosed. A system includes a cutting device, a tracking and navigation system and a cutting system in operable communication with the cutting device and the tracking and navigation system. The cutting device includes a communication system, a cutting element, and a plurality of optical trackers. The tracking and navigation system is configured to detect a location of optical trackers. The control system is configured to cause the tracking and navigation system to detect the location of the cutting device, determine a revised shape for an implant cavity, cause the cutting device to cut the implant cavity to the revised shape, select a shape for a cone to be placed in the revised implant cavity, and machine the cone to the selected shape.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: April 11, 2023
    Assignee: Smith & Nephew, Inc.
    Inventors: Roger Ryan Dees, Jr., Sied W. Janna, Daniel Farley, Branislav Jaramaz
  • Publication number: 20230063081
    Abstract: Patient-specific guides for the Latarjet procedure, as well as surgical systems and methods of performing the Latarjet procedure to treat glenohumeral instability using such patient-specific guides are disclosed. A patient-specific coracoid guide and a patient-specific glenoid guide may be configured based on preoperatively generated three-dimensional models of the patient's shoulder anatomy. Guides may be configured for coracoid graft preparation and glenoid decortication. The coracoid graft may be placed in the desired position based on three-dimensional (3D) preoperative planning.
    Type: Application
    Filed: November 3, 2022
    Publication date: March 2, 2023
    Inventors: Branislav JARAMAZ, Daniel FARLEY
  • Publication number: 20230056596
    Abstract: Disclosed herein is a system and a method for registering a surgical site to a surgical navigation system when the surgical site contains an implant for revision joint replacement surgery. The method creates a depth map of the surgical site and provides a possible identification of the existing implant using surface matching algorithms. The model of the implant is iteratively oriented with respect to the to the depth map until an optimal fit is achieved. Once the implant has been identified and localized, the registered landmarks are used in robotic-assisted surgery.
    Type: Application
    Filed: August 8, 2022
    Publication date: February 23, 2023
    Applicants: Smith & Nephew, Inc., Smith & Nephew Orthopaedics AG, Smith & Nephew Asia Pacific Pte. Limited
    Inventors: Daniel Farley, Nathaniel M. Lenz
  • Publication number: 20230002777
    Abstract: The present invention relates to a nucleic acid sequence comprising a nucleotide of interest and a tryptophan RNA-binding attenuation protein (TRAP) binding site, and optionally a Kozak sequence, wherein said TRAP binding site overlaps the Kozak sequence and/or the ATG start codon of the nucleotide of interest. The present invention further relates to a nucleic acid sequence comprising a nucleotide of interest and a Kozak sequence, wherein said Kozak sequence comprises a portion of a tryptophan RNA-binding attenuation protein (TRAP) binding site. The present invention further relates to a nucleic acid sequence comprising a nucleotide of interest and TRAP binding site wherein the TRAP binding site comprises a portion of the start codon ATG of said nucleotide of interest or wherein the ATG start codon comprises a portion of the TRAP binding site.
    Type: Application
    Filed: November 11, 2020
    Publication date: January 5, 2023
    Inventor: Daniel Farley
  • Patent number: 11532402
    Abstract: Systems and methods for determining a care plan for a patient are disclosed. Data from a one or more databases are received or retrieved and used to determine a preferred care plan used to perform a surgical procedure or otherwise treat a patient. The data may include data pertaining to a patient, a healthcare professional, a healthcare facility, an implant, economic data, simulation data, imaging data, and/or the like. The data may be used to determine a plan that provides a positive outcome and patient satisfaction. The data may be updated over time or in real time to improve or refine the determination of care plans for the current patient or other patients.
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: December 20, 2022
    Assignees: Smith & Nephew, Inc., Smith & Nephew Orthopaedics AG, Smith & Nephew Asia Pacific Pte. Limited
    Inventors: Daniel Farley, Sied W. Janna, Scott K. Laster, Zachary C. Wilkinson
  • Patent number: 11517334
    Abstract: Patient-specific guides for the Latarjet procedure, as well as surgical systems and methods of performing the Latarjet procedure to treat glenohumeral instability using such patient-specific guides are disclosed. A patient-specific coracoid guide and a patient-specific glenoid guide may be configured based on preoperatively generated three-dimensional models of the patient's shoulder anatomy. Guides may be configured for coracoid graft preparation and glenoid decortication. The coracoid graft may be placed in the desired position based on three-dimensional (3D) preoperative planning.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: December 6, 2022
    Assignees: Smith & Nephew, Inc., Smith & Nephew Asia Pacific Pte. Limited, Smith & Nephew Orthopaedics AG
    Inventors: Branislav Jaramaz, Daniel Farley
  • Publication number: 20220354539
    Abstract: An automated spatial frame is disclosed. The spatial frame may include a master controller unit arranged and configured as a centralized controller for exchanging data with a remote computing system, exchanging data with a plurality of automated struts, and delivering power to the automated struts. Thus arranged, the master-controller unit may be configured as a fully integrated, rechargeable power supply/controller unit for powering and controlling the automated struts. In one embodiment, the master-controller unit is coupled to an external surface of a platform. The platform acting as a conduit for coupling the master-controller unit to the automated struts. As such, at least one of the platforms provides integrated connectivity to the automated struts. In one embodiment, the struts may be wireless automated strut including a motor, a power source, and a wireless communications module for communicating with an external computing system.
    Type: Application
    Filed: September 23, 2020
    Publication date: November 10, 2022
    Applicants: Smith & Nephew, Inc., Smith & Nephew Orthopaedics AG, Smith & Nephew Asia Pacific Pte. Limited
    Inventors: Joseph M. Ferrante, Daniel Farley, Darren Wilson, Sied W. Janna, Brian Roberts
  • Publication number: 20220348958
    Abstract: A modified U1 snRNA, wherein said modified U1 snRNA has been modified to bind to a nucleotide sequence within the packaging region of a lentiviral vector genome sequence.
    Type: Application
    Filed: July 23, 2020
    Publication date: November 3, 2022
    Inventors: Daniel Farley, Jordan Wright
  • Publication number: 20220273281
    Abstract: Methods and systems for planning a joint replacement surgical procedure are disclosed. A musculoskeletal model for a patients joint and patient biometric data are received. A joint distraction device is positioned in the patients joint during the joint replacement surgical procedure, and the position and orientation of the joint distraction device are tracked as the patient's joint is moved through a range of motion in order to determine a magnitude of a force applied to the joint distraction device. A surgical plan for performing the joint replacement surgical procedure is provided based on the magnitude of the force applied throughout the range of motion, the musculoskeletal model, and the patient biometric data. The surgical plan includes implant position information, bone resection information, and/or ligament balancing information.
    Type: Application
    Filed: August 7, 2019
    Publication date: September 1, 2022
    Inventors: Brian W. MCKINNON, Daniel FARLEY
  • Publication number: 20220265355
    Abstract: Disclosed herein are systems and devices for performing computer-aided surgical navigation. Specifically, a system for augmented reality assisted trauma fixation, which displays various views of one or more tracked items, including a guide device, a fixation plate, a surgical tracking device, and an augmented reality display. The guide device having a tip, a handle, and a fixation guide. The fixation plate having at least one aperture designed to receive the tip of the guide. The surgical tracking device configured to track one or more trackable objects associated with the guide, fixation plate, and display, and thereby calculate a location of a fixation device, such as a screw, relative to the fixation plate.
    Type: Application
    Filed: July 16, 2020
    Publication date: August 25, 2022
    Inventors: Joseph Michael FERRANTE, Charles Christopher HEOTIS, Namal NAWANA, Constantinos NIKOU, Daniel FARLEY, Brian W. MCKINNON