Abstract: The invention relates to an artificial ophthalmic lens (20) containing an anterior optical surface (21) and a posterior optical surface (22), at least one of which contains a multifocal optical diffractive profile (25). A cross apodized profile part (25?) is formed on the diffractive profile (25) wherein phase shifting elements (27) are provided alternately forming the elements of a decreasingly apodized series (40) and an increasingly apodized series (41) in such a way that the decreasing and increasing elements of the two series (40, 41) form envelope curves that meet at a common intersection point (45). The invention further relates to a method for the production of such an artificial ophthalmic lens (20).

Abstract: The present invention relates to a topical pharmaceutical composition comprising pregabalin and a reduced micellar phospholipid as an active ingredient, which results in a prolonged analgesic effect of pregabalin. The product can reduce neuropathic pain by at least 5 hours.

Abstract: Topical formulation containing pregabalin for long-term analgesic activity. The composition is prepared using high shear mixers or homogenizers such as HPH or ultrasonic devices, which changes the structure of the composition. The analgesic effect of the compounds of the present invention is significantly increased compared to reference formulations homogenized with equipment of the same quantitative composition but less shearing forces.

Abstract: The present invention relates to a topical pharmaceutical composition comprising pregabalin and a reduced micellar phospholipid as an active ingredient, which results in a prolonged analgesic effect of pregabalin. The product can reduce neuropathic pain by at least 5 hours.

Abstract: An apparatus and method for actuating a valve stem between an open position and a closed position and for taking one or more valve gated nozzle out of service is disclosed. The hot runner includes a valve gated nozzle having a valve stem, the valve stem coupled to a piston that is held against an actuation plate via pressurized air. When a valve stem becomes stuck in a gate of the hot runner, the actuation plate can continue to move while the piston remains stationary. The valve stem may also be protected from an over force situation such as if the valve stem encounters an obstruction as the actuation plate is moving toward the closed position.

Abstract: A hot runner nozzle includes a nozzle body, an annular outlet channel in the nozzle body, a source channel upstream of the annular outlet channel in the nozzle body, and a flow transition channel in the nozzle body. The flow transition channel interconnects the source channel with a part-annular segment of the annular outlet channel. The flow transition channel widens in a downstream direction and has a non-uniform cross-sectional channel thickness in either or both of the longitudinal (downstream) and transverse directions. The geometry of the flow transition channel may promote at least one of a uniform velocity profile and a uniform temperature profile in a generated annular or part-annular melt flow.

Abstract: An apparatus and method for actuating a valve stem between an open position and a closed position and for taking one or more valve gated nozzle out of service is disclosed. The hot runner includes a valve gated nozzle having a valve stem, the valve stem coupled to a piston that is held against an actuation plate via pressurized air. When a valve stem becomes stuck in a gate of the hot runner, the actuation plate can continue to move while the piston remains stationary. The valve stem may also be protected from an over force situation such as if the valve stem encounters an obstruction as the actuation plate is moving toward the closed position.

Abstract: An apparatus and method for actuating a valve stem between an open position and a closed position and for taking one or more valve gated nozzle out of service is disclosed. The hot runner includes a valve gated nozzle having a valve stem, the valve stem coupled to a piston that is held against an actuation plate via pressurized air. When a valve stem becomes stuck in a gate of the hot runner, the actuation plate can continue to move while the piston remains stationary. The valve stem may also be protected from an over force situation such as if the valve stem encounters an obstruction as the actuation plate is moving toward the closed position.

Abstract: A large area position-sensitive single-photon detector and radiation detector is described. Photon detectors are coupled to a large area panel configured with an equipotential feedthrough chamber that operates in combination with a photocathode of a hemispherical window to provide electrostatic focusing for the photoelectrons. The panels can be assembled into an enveloping structure, such as a PET scanner, which is globally and/or locally curved, such as into a sphere, ovoid, elongated cylinder, or similar structure providing significant sensitive surface surrounding an object, such as a patient being scanned in a medical positron emission tomography (PET) scanner. Increased sensitivity is provided in response to registering radiation by surrounding the patient, so that reduced patient radiation dosing levels are required.

Abstract: A hot runner nozzle includes a nozzle body, an annular outlet channel in the nozzle body, a source channel upstream of the annular outlet channel in the nozzle body, and a flow transition channel in the nozzle body. The flow transition channel interconnects the source channel with a part-annular segment of the annular outlet channel. The flow transition channel widens in a downstream direction and has a non-uniform cross-sectional channel thickness in either or both of the longitudinal (downstream) and transverse directions. The geometry of the flow transition channel may promote at least one of a uniform velocity profile and a uniform temperature profile in a generated annular or part-annular melt flow.

Abstract: An apparatus and method for actuating a valve stem between an open position and a closed position and for taking one or more valve gated nozzle out of service is disclosed. The hot runner includes a valve gated nozzle having a valve stem, the valve stem coupled to a piston that is held against an actuation plate via pressurized air. When a valve stem becomes stuck in a gate of the hot runner, the actuation plate can continue to move while the piston remains stationary. The valve stem may also be protected from an over force situation such as if the valve stem encounters an obstruction as the actuation plate is moving toward the closed position.

Abstract: A large area position-sensitive single-photon detector and radiation detector is described. Photon detectors are coupled to a large area panel configured with an equipotential feedthrough chamber that operates in combination with a photocathode of a hemispherical window to provide electrostatic focusing for the photoelectrons. The panels can be assembled into an enveloping structure, such as a PET scanner, which is globally and/or locally curved, such as into a sphere, ovoid, elongated cylinder, or similar structure providing significant sensitive surface surrounding an object, such as a patient being scanned in a medical positron emission tomography (PET) scanner. Increased sensitivity is provided in response to registering radiation by surrounding the patient, so that reduced patient radiation dosing levels are required.

Abstract: A scalable vacuum photosensor configured to simplify mass production with a housing having an evacuated first side at an ultrahigh vacuum and a second side which does not require high vacuum. The first side of the device is sealed to a base plate, having a central electron readout element, using an oxide-free sealing technique, with the deposited sealing areas serving as high voltage throughputs from the first to second sides. A conductive photocathode layer on the transparent first side converts photons to photoelectrons and concentrates the photoelectrons upon the readout. The first and second sides together form an electrostatic lens for accelerating and focusing photoelectrons upon the readout, preferably having a scintillator which generates secondary light measured by an optical detector in the second side of the housing.

Abstract: A dynamic mixer and associated injection molding system for mixing a melt flow. The injection molding system includes: a hot runner assembly having a plurality of splits; an injection unit that delivers a melt flow to the plurality of splits in the hot runner assembly via a melt channel; and a dynamic mixer incorporated into the melt channel upstream from the plurality of splits, wherein the dynamic mixer includes a rotor assembly configured to be rotationally driven by the melt flow, and wherein the rotor assembly is further configured to mix the melt flow passing through the melt channel.

Abstract: Disclosed herein is a stationary platen of a mold clamp for use with a molding system. The stationary platen includes a platen base configured to accept a first mold assembly of a mold, the platen base also defines a receptacle for embedding, in use, a bridge runner system. The bridge runner system is configured to fluidly connect, at least in part, a source of molding material with a molding cavity defined, at least in part, by a mold insert accepted in the first mold assembly.

Abstract: Disclosed herein is a melt distribution apparatus for a molding system having a geometrically balanced network of runners for distributing a melt of molding material from a melt inlet to a rectangular array of melt outlets having a first number of melt outlets in a first reference direction and a second number of melt outlets in a second reference direction, at least one of the first and the second number being an odd number in excess of three.

Abstract: Disclosed herein is a mold module from a set of substantially structurally independent mold modules of at least one of a first mold assembly or a second mold assembly. The first mold assembly and the second mold assembly for accepting, in use, a plurality of first mold inserts and second mold inserts, respectively, to define, in use, a plurality of substantially identical molding cavities therebetween. A subset of at least one of the first mold inserts or the second mold inserts being accepted in the mold module.

Abstract: According to embodiments of the present invention, there is provided a split mold insert. The split mold insert comprises a body comprising: a front face portion defining, in part, a first portion of a molding cavity; a planar upper face portion for cooperation with a complementary lower portion of a first mold insert, the first mold insert defining a second portion of the molding cavity; the planar upper face portion defining a split line between the first and second portions of the molding cavity; a locking interface defined on an outermost portion of the body, the locking interface configured to cooperate with a blocking member associated with a cavity mold insert.

Abstract: An imaging camera includes a housing that defines a proximal end and a distal end. A Fresnel lens is installed in the proximal end of the housing. Moreover, a reflection mode photocathode is installed in the distal end of the housing opposite the Fresnel lens. An electron sensor is disposed in the center of the Fresnel lens. A conductive layer is disposed on the interior of the housing. Further, the Fresnel lens establishes plural concentric optically passive surfaces that are parallel to a central axis defined by the imaging camera. A conductive layer is disposed on each optically passive surface, and an electron lens is established by the conductive layer on the interior of the housing and the conductive layers on the Fresnel lens.

Abstract: An imaging camera includes a housing that defines a proximal end and a distal end. A Fresnel lens is installed in the proximal end of the housing. Moreover, a reflection mode photocathode is installed in the distal end of the housing opposite the Fresnel lens. An electron sensor is disposed in the center of the Fresnel lens. A conductive layer is disposed on the interior of the housing. Further, the Fresnel lens establishes plural concentric optically passive surfaces that are parallel to a central axis defined by the imaging camera. A conductive layer is disposed on each optically passive surface, and an electron lens is established by the conductive layer on the interior of the housing and the conductive layers on the Fresnel lens.