Patents by Inventor Daniel Fletcher
Daniel Fletcher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210348243Abstract: The present disclosure relates to methods using CRISPR-Cas13 enzyme, complexed with SARS-CoV-2 crRNA guide RNAs to detect and quantify the presence of SARS-CoV-2 RNA in a sample with enhanced specificity and sensitivity. These methods can be used to diagnose SARS-CoV-2 infection, quantify the concentration of SARS-CoV-2 RNA present in a sample, identify the presence of different SARS-CoV-2 splice variants, subtypes, or mutations, and to monitor reactivation of SARS-CoV-2 transcription.Type: ApplicationFiled: March 18, 2021Publication date: November 11, 2021Inventors: Melanie Ott, Parinaz Fozouni, Jennifer A. Doudna, Daniel A. Fletcher, David Savage, Emeric Charles, Sungmin Son, Gagandeep Renuka Kumar, Neil Switz
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Patent number: 11129532Abstract: A portable retinal imaging device for imaging the fundus of the eye. The device includes an ocular imaging device containing ocular lensing and filters, a fixation display, and a light source, and is configured for coupling to a mobile device containing a camera, display, and application programming for controlling retinal imaging. The light source is configured for generating a sustained low intensity light (e.g., IR wavelength) during preview, followed by a light flash during image capture. The ocular imaging device works in concert with application programming on the mobile device to control subject gaze through using a fixation target when capturing retinal imaging on the mobile device, which are then stitched together using imaging processing into an image having a larger field of view.Type: GrantFiled: October 9, 2018Date of Patent: September 28, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniel Fletcher, Robi Maamari, Neil Switz, Todd Margolis, Frank Myers, III, Kim Tyson, Clay Reber
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Patent number: 10989907Abstract: An imaging system consisting of a cell-phone with camera as the detection part of an optical train which includes other components. Optionally, an illumination system to create controlled contrast in the sample. Uses include but are not limited to disease diagnosis, symptom analysis, and post-procedure monitoring, and other applications to humans, animals, and plants.Type: GrantFiled: February 10, 2020Date of Patent: April 27, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniel Fletcher, Wendy Hansen, Neil Switz, David N. Breslauer, Erik Douglas, Robi Maamari, Wilbur Lam, Jesse Dill
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Patent number: 10918930Abstract: A golf mat that has a natural feel and mitigates injury during mat striking includes: a base, the base including a main structure with an upper surface and an open topped cavity in the upper surface; and an insert sized to be accommodated in the cavity, the insert including a layer of solid polymeric material selected to have shock absorption properties greater than the main structure; and artificial turf installed on the base and overlying at least a portion of the main structure and the insert.Type: GrantFiled: October 4, 2017Date of Patent: February 16, 2021Assignee: FIBERBUILT MANUFACTURING INC.Inventors: Michael Hooper, Scott Nichol, Daniel Fletcher
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Publication number: 20200336630Abstract: An improved system and methods for enhancing the imaging of cameras included with wireless mobile devices, such as cellular phone or tablets. The imaging system includes a releasable optical attachment for imaging skin surfaces and cavities of the body. The releasable optical attachment comprises optical enhancement elements such as magnifying lenses, illumination diverting elements, and filters. Images can be viewed and analyzed on the mobile device, or transmitted to another location/device for analysis by a person or software. The results can be used to provide diagnosis, or for a variety of other applications including image comparison over time and product recommendations.Type: ApplicationFiled: March 5, 2020Publication date: October 22, 2020Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniel Fletcher, Erik Douglas, Amy Sheng, Wilbur Lam, Robi Maamari
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Publication number: 20200257103Abstract: An imaging system consisting of a cell-phone with camera as the detection part of an optical train which includes other components. Optionally, an illumination system to create controlled contrast in the sample. Uses include but are not limited to disease diagnosis, symptom analysis, and post-procedure monitoring, and other applications to humans, animals, and plants.Type: ApplicationFiled: February 10, 2020Publication date: August 13, 2020Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniel Fletcher, Wendy Hansen, Neil Switz, David N. Breslauer, Erik Douglas, Robi Maamari, Wilbur Lam, Jesse Dill
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Publication number: 20200237216Abstract: A handheld, ocular imaging device and system that employs the camera, processor and programming of a mobile phone, tablet or other smart device coupled to optical elements and illumination elements that can be used to image the structures of the eye in non-clinical locations, for example is presented. The modular device provides multi-functionality (fluorescein imaging, fluorescence, brightfield, infrared (IR) imaging, near-infrared (NIR) imaging) and multi-region imaging (retinal, corneal, external, etc.) of the eye along with the added features of image processing, storage and wireless data transmission for remote storage and evaluation. Acquired ocular images can also be transmitted directly from the device to the electronic medical records of a patient without the need for an intermediate computer system.Type: ApplicationFiled: December 19, 2019Publication date: July 30, 2020Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniel Fletcher, Robi Maamari, Neil Switz, Todd P. Margolis
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Publication number: 20200159001Abstract: An imaging system consisting of a cell-phone with camera as the detection part of an optical train which includes other components. Optionally, an illumination system to create controlled contrast in the sample. Uses include but are not limited to disease diagnosis, symptom analysis, and post-procedure monitoring, and other applications to humans, animals, and plants.Type: ApplicationFiled: September 23, 2019Publication date: May 21, 2020Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniel Fletcher, Wendy Hansen, Neil Switz, David N. Breslauer, Erik Douglas, Robi Maamari, Wilbur Lam, Jesse Dill
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Patent number: 10616457Abstract: An improved system and methods for enhancing the imaging of cameras included with wireless mobile devices, such as cellular phone or tablets. The imaging system includes a releasable optical attachment for imaging skin surfaces and cavities of the body. The releasable optical attachment comprises optical enhancement elements such as magnifying lenses, illumination diverting elements, and filters. Images can be viewed and analyzed on the mobile device, or transmitted to another location/device for analysis by a person or software. The results can be used to provide diagnosis, or for a variety of other applications including image comparison over time and product recommendations.Type: GrantFiled: January 11, 2017Date of Patent: April 7, 2020Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniel Fletcher, Erik Douglas, Amy Sheng, Wilbur Lam, Robi Maamari
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Patent number: 10578851Abstract: An automated slide scanning system, comprising one or more optical elements, including an objective, having an optical path configured to be disposed within view of a camera of a portable device. An automated stage disposed within the optical path, the automated stage comprising a platform configured for receiving a slide containing a biological sample and having a drive mechanism for translating the stage in at least one direction with respect to said objective. A communications interface coupled to the automated stage, and is configured for receiving a command from the portable device to control operation of the mechanical stage.Type: GrantFiled: April 13, 2017Date of Patent: March 3, 2020Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniel A. Fletcher, Michael V. D'Ambrosio, Arunan Skandarajah, Frank B. Myers, III, Clay D. Reber
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Patent number: 10542885Abstract: A handheld, ocular imaging device and system that employs the camera, processor and programming of a mobile phone, tablet or other smart device coupled to optical elements and illumination elements that can be used to image the structures of the eye in home-based, ambulatory-care, hospital-based, or emergency-care settings, is presented. The modular device provides multi-functionality (fluorescein imaging, fluorescence, brightfield, infrared (IR) imaging, near-infrared (NIR) imaging) and multi-region imaging (retinal, corneal, external, etc.) of the eye along with the added features of image processing, storage and wireless data transmission for remote storage and evaluation. Acquired ocular images can also be transmitted directly from the device to the electronic medical records of a patient without the need for an intermediate computer system.Type: GrantFiled: April 8, 2016Date of Patent: January 28, 2020Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniel Fletcher, Robi Maamari, Neil Switz, Todd P. Margolis
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Publication number: 20190276537Abstract: Segregation modulation therapeutics comprise a recombinant macromolecule comprising an effector-binding module and an anchor-binding module joined by a linker, wherein the modules are specific for an effector and an anchor, respectively of a target cell, and bound thereto, the enforces an effector-anchor complex such that the effector and anchor molecules are spatially co-localized on the target cell.Type: ApplicationFiled: May 17, 2019Publication date: September 12, 2019Applicant: The Regents of the University of CaliforniaInventors: Daniel A. Fletcher, Matthew H. Bakalar, Eva M. Schmid
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Publication number: 20190243117Abstract: An imaging system consisting of a cell-phone with camera as the detection part of an optical train which includes other components. Optionally, an illumination system to create controlled contrast in the sample. Uses include but are not limited to disease diagnosis, symptom analysis, and post-procedure monitoring, and other applications to humans, animals, and plants.Type: ApplicationFiled: October 3, 2018Publication date: August 8, 2019Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniel Fletcher, Wendy Hansen, Neil Switz, David N. Breslauer, Erik Douglas, Robi Maamari, Wilbur Lam, Jesse Dill
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Publication number: 20190232144Abstract: A golf mat that has a natural feel and mitigates injury during mat striking includes: a base, the base including a main structure with an upper surface and an open topped cavity in the upper surface; and an insert sized to be accommodated in the cavity, the insert including a layer of solid polymeric material selected to have shock absorption properties greater than the main structure; and artificial turf installed on the base and overlying at least a portion of the main structure and the insert.Type: ApplicationFiled: October 4, 2017Publication date: August 1, 2019Inventors: MICHAEL HOOPER, SCOTT NICHOL, DANIEL FLETCHER
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Publication number: 20190117064Abstract: A portable retinal imaging device for imaging the fundus of the eye. The device includes an ocular imaging device containing ocular lensing and filters, a fixation display, and a light source, and is configured for coupling to a mobile device containing a camera, display, and application programming for controlling retinal imaging. The light source is configured for generating a sustained low intensity light (e.g., IR wavelength) during preview, followed by a light flash during image capture. The ocular imaging device works in concert with application programming on the mobile device to control subject gaze through using a fixation target when capturing retinal imaging on the mobile device, which are then stitched together using imaging processing into an image having a larger field of view.Type: ApplicationFiled: October 9, 2018Publication date: April 25, 2019Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniel Fletcher, Robi Maamari, Neil Switz, Todd Margolis, Frank Myers, III, Kim Tyson, Clay Reber
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Patent number: 10126539Abstract: An imaging system consisting of a cell-phone with camera as the detection part of an optical train which includes other components. Optionally, an illumination system to create controlled contrast in the sample. Uses include but are not limited to disease diagnosis, symptom analysis, and post-procedure monitoring, and other applications to humans, animals, and plants.Type: GrantFiled: November 9, 2016Date of Patent: November 13, 2018Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniel Fletcher, Wendy Hansen, Neil Switz, David N. Breslauer, Erik Douglas, Robi Maamari, Wilbur Lam, Jesse Dill
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Publication number: 20170285320Abstract: An automated slide scanning system, comprising one or more optical elements, including an objective, having an optical path configured to be disposed within view of a camera of a portable device. An automated stage disposed within the optical path, the automated stage comprising a platform configured for receiving a slide containing a biological sample and having a drive mechanism for translating the stage in at least one direction with respect to said objective. A communications interface coupled to the automated stage, and is configured for receiving a command from the portable device to control operation of the mechanical stage.Type: ApplicationFiled: April 13, 2017Publication date: October 5, 2017Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniel A. Fletcher, Michael V. D'Ambrosio, Arunan Skandarajah, Frank B. Myers, III, Clay D. Reber
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Patent number: D901042Type: GrantFiled: April 1, 2019Date of Patent: November 3, 2020Assignee: Fiberbuilt Manufacturing Inc.Inventors: Daniel Fletcher, Michael Hooper, Scott Nichol, Courtney MacDonald
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Patent number: D906795Type: GrantFiled: April 1, 2019Date of Patent: January 5, 2021Assignee: Fiberbuilt Manufacturing Inc.Inventors: Daniel Fletcher, Michael Hooper, Scott Nichol, Courtney MacDonald
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Patent number: D966084Type: GrantFiled: December 9, 2020Date of Patent: October 11, 2022Assignee: FIBERBUILT MANUFACTURING INC.Inventors: Daniel Fletcher, Michael Hooper, Scott Nichol, Courtney MacDonald