Patents by Inventor Daniel Flickinger

Daniel Flickinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220382031
    Abstract: A method of imaging a sample providing light from a light source, directing the provided light into an extended focus, scanning the extended focus across a wavefront modulating element that modulates amplitudes of the light along the extended focus, providing the modulated light to the sample, detecting light emitted from the sample in response to excitation by the modulated light, and generating an image of the sample based on the detected fluorescence emission light.
    Type: Application
    Filed: November 11, 2020
    Publication date: December 1, 2022
    Inventors: Kaspar PodgorskI, Daniel Flickinger
  • Patent number: 10901194
    Abstract: A microscope system including: a source of light; a sample objective configured for focusing the light at a focal plane within a sample; a remote focus unit configured for changing a position of the focal plane along an axis perpendicular to the focal plane; one or more optical element configured for directing the focused light to a location within the focal plane; and a detector configured for detecting light emitted from the focal plane within the sample; wherein the one or more optical element is located after the remote focus unit along a beam path of the light from the source to the sample objective, such that the changing the position of the focal plane along the axis is performed before the directing the focused light to the location within the focal plane.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: January 26, 2021
    Assignee: Howard Hughes Medical Institute
    Inventors: Karel Svoboda, Daniel Flickinger, Nicholas Sofroniew
  • Patent number: 10830701
    Abstract: Techniques are described for imaging a sample where the techniques include acquiring a raster scan image of the sample, providing light from a light source, directing the light into a plurality of different light beam paths at different times, providing light in each of the plurality of light beam paths through an objective lens to the sample, and providing light in each of the plurality of beams to different locations within the sample. Fluorescence emission light from the sample is detected in response to excitation by light in each of the plurality of light beam paths, where the detected fluorescence emission light corresponds to fluorescence intensity projections of the sample with low mutual coherence, and an image of the sample is generated based on the detected fluorescence emission light and based on the raster scan image.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: November 10, 2020
    Assignee: Howard Hughes Medical Institute
    Inventors: Kaspar Podgorski, Daniel Flickinger, Abbas Kazemipour
  • Patent number: 10295811
    Abstract: A microscope system including: a source of light; a sample objective configured for focusing the light at a focal plane within a sample; a remote focus unit configured for changing a position of the focal plane along an axis perpendicular to the focal plane; one or more optical element configured for directing the focused light to a location within the focal plane; and a detector configured for detecting light emitted from the focal plane within the sample; wherein the one or more optical element is located after the remote focus unit along a beam path of the light from the source to the sample objective, such that the changing the position of the focal plane along the axis is performed before the directing the focused light to the location within the focal plane.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: May 21, 2019
    Assignee: Howard Hughes Medical Institute
    Inventors: Karel Svoboda, Daniel Flickinger, Nicholas Sofroniew
  • Publication number: 20190101735
    Abstract: A microscope system including: a source of light; a sample objective configured for focusing the light at a focal plane within a sample; a remote focus unit configured for changing a position of the focal plane along an axis perpendicular to the focal plane; one or more optical element configured for directing the focused light to a location within the focal plane; and a detector configured for detecting light emitted from the focal plane within the sample; wherein the one or more optical element is located after the remote focus unit along a beam path of the light from the source to the sample objective, such that the changing the position of the focal plane along the axis is performed before the directing the focused light to the location within the focal plane.
    Type: Application
    Filed: November 15, 2018
    Publication date: April 4, 2019
    Inventors: Karel Svoboda, Daniel Flickinger, Nicholas Sofroniew
  • Publication number: 20180321154
    Abstract: Techniques are described for imaging a sample where the techniques include acquiring a raster scan image of the sample, providing light from a light source, directing the light into a plurality of different light beam paths at different times, providing light in each of the plurality of light beam paths through an objective lens to the sample, and providing light in each of the plurality of beams to different locations within the sample. Fluorescence emission light from the sample is detected in response to excitation by light in each of the plurality of light beam paths, where the detected fluorescence emission light corresponds to fluorescence intensity projections of the sample with low mutual coherence, and an image of the sample is generated based on the detected fluorescence emission light and based on the raster scan image.
    Type: Application
    Filed: May 7, 2018
    Publication date: November 8, 2018
    Inventors: Kaspar Podgorski, Daniel Flickinger, Abbas Kazemipour
  • Publication number: 20170123196
    Abstract: A microscope system including: a source of light; a sample objective configured for focusing the light at a focal plane within a sample; a remote focus unit configured for changing a position of the focal plane along an axis perpendicular to the focal plane; one or more optical element configured for directing the focused light to a location within the focal plane; and a detector configured for detecting light emitted from the focal plane within the sample; wherein the one or more optical element is located after the remote focus unit along a beam path of the light from the source to the sample objective, such that the changing the position of the focal plane along the axis is performed before the directing the focused light to the location within the focal plane.
    Type: Application
    Filed: November 1, 2016
    Publication date: May 4, 2017
    Inventors: Karel Svoboda, Daniel Flickinger, Nicholas Sofroniew
  • Patent number: 6050490
    Abstract: This disclosure provides a handheld writing device and a related data entry system. In particular, a digital electronic clipboard is used to mount pages or forms utilized in forms processing applications, such as inventory tracking. A stylus having a writing tip at one end of the stylus and a bar code scanning mechanism at another end of the stylus is used to enter data on the pages or forms and scan bar codes appearing on the pages or forms themselves, or on a separate item to be associated with the form. The system detects whether bar code data or stylus position data is being generated and causes its CPU to responsively process entered data. In an alternative embodiment, the system also permits generation of only one of stylus position data and bar code data at any given time.
    Type: Grant
    Filed: October 31, 1997
    Date of Patent: April 18, 2000
    Assignee: Hewlett-Packard Company
    Inventors: Robert Leichner, Bo Curry, Daniel Flickinger
  • Patent number: 5629499
    Abstract: A low-cost and rugged electronic apparatus to store and to transfer written information. The apparatus includes a pen and a board, which has a sensing mechanism, a memory device and a communication link. When the pen imprints symbols to the board, the symbols are not concurrently electronically displayed. But the symbols are detected by the sensing mechanism, stored in the memory device, and can later be transferred to an electronic device through the communication link.
    Type: Grant
    Filed: December 14, 1995
    Date of Patent: May 13, 1997
    Assignee: Hewlett-Packard Company
    Inventors: Daniel Flickinger, Bo U. Curry
  • Patent number: D354772
    Type: Grant
    Filed: February 18, 1994
    Date of Patent: January 24, 1995
    Assignee: Hewlett-Packard Company
    Inventors: Daniel Flickinger, Lynn C. Beckley, John W. Lai