Abstract: Implementations are provided for scalable cloud backup. A coordinator process can manage worker processes on nodes to package file system data that is targeted for cloud backup into node local upload objects. File data can be arranged into distinct block offsets of the node local upload object. A set of metadata tables can be generated that characterize each file that is backed up as well as file block location information for each data block. The node local upload objects can be uploaded to a cloud service provider. The set of metadata tables generated by the worker process can be coalesced into a global set of metadata tables that describe the data that has been backed up. In one implementation, after an initial cloud backup has occurred, a snapshot service of the file system can be used to incrementally backup blocks of the file that have been changed.

Abstract: There is provided a high throughput automated single molecule image collection and processing system that requires minimal initial user input. The unique features embodied in the present disclosure allow automated collection and initial processing of optical images of single molecules and their assemblies. Correct focus may be automatically maintained while images are collected. Uneven illumination in fluorescence microscopy is accounted for, and an overall robust imaging operation is provided yielding individual images prepared for further processing in external systems. Embodiments described herein are useful in studies of any macromolecules such as DNA, RNA, peptides and proteins. The automated image collection and processing system and method of same may be implemented and deployed over a computer network, and may be ergonomically optimized to facilitate user interaction.

Abstract: There is provided a high throughput automated single molecule image collection and processing system that requires minimal initial user input. The unique features embodied in the present disclosure allow automated collection and initial processing of optical images of single molecules and their assemblies. Correct focus may be automatically maintained while images are collected. Uneven illumination in fluorescence microscopy is accounted for, and an overall robust imaging operation is provided yielding individual images prepared for further processing in external systems. Embodiments described herein are useful in studies of any macromolecules such as DNA, RNA, peptides and proteins. The automated image collection and processing system and method of same may be implemented and deployed over a computer network, and may be ergonomically optimized to facilitate user interaction.