Abstract: This specification describes systems for unmanned vehicle carrying and deployment. In some examples, a system includes a deployable robot including at least one rotatable flipper disposed on a surface of the deployable robot. The system includes a base unmanned vehicle configured for carrying and deploying the deployable robot. The base unmanned vehicle includes a base robot chassis, and the base robot chassis includes a platform for securing the deployable robot and at least one retention bracket disposed on the platform. The flipper is configured to rotate in a first rotational direction to lock the deployable robot onto the base robot chassis by engaging with the retention bracket.

Abstract: To meet the stringent requirements on simulating motion of an object, a body state of the object needs to be processed in real time while minimizing an error of deviating from the trajectory and time as specified, using limited computing resources. The present disclosure simulates physical aspects of an object in motion by generating a rigid body model that includes external force data and data representing the object. The simulator determines a body state of the object with specific velocity, altitude, and heading at a specific time-tick in real-time. The simulator determines forces applied to the object to move the object and update the rigid model in the real-time process iterations. The disclosed technology uses non-linear inversion dynamics controllers to compute the body forces for following a prescribed trajectory and a rigid body model solver with advanced integration techniques providing low-latency, accuracy, and integrity of linear and rotational body states.

Abstract: Compositions and methods for treating cancer in a subject in need thereof are described that includes administering a therapeutically effective amount of an oligonucleotide that inhibits the binding of splicing regulator SRSF1 or SRSF2 to MDM2 exon 4 or 11.

Abstract: The present disclosure provides compounds and methods useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

Abstract: Compositions and methods for treating cancer in a subject in need thereof are described that includes administering a therapeutically effective amount of an oligonucleotide that inhibits the binding of splicing regulator SRSF1 or SRSF2 to MDM2 exon 4 or 11.

Abstract: Compositions and methods for treating cancer in a subject in need thereof are described that includes administering a therapeutically effective amount of an oligonucleotide that inhibits the binding of splicing regulator SRSF1 or SRSF2 to MDM2 exon 4 or 11.

Abstract: Implementations are provided for scalable cloud backup. A coordinator process can manage worker processes on nodes to package file system data that is targeted for cloud backup into node local upload objects. File data can be arranged into distinct block offsets of the node local upload object. A set of metadata tables can be generated that characterize each file that is backed up as well as file block location information for each data block. The node local upload objects can be uploaded to a cloud service provider. The set of metadata tables generated by the worker process can be coalesced into a global set of metadata tables that describe the data that has been backed up. In one implementation, after an initial cloud backup has occurred, a snapshot service of the file system can be used to incrementally backup blocks of the file that have been changed.

Abstract: Compositions and methods for treating cancer in a subject in need thereof are described that includes administering a therapeutically effective amount of an oligonucleotide that inhibits the binding of splicing regulator SRSF1 or SRSF2 to MDM2 exon 4 or 11.

Abstract: A method for distributing inventory data for a distributed cache provided by a plurality of wireless mobile communication devices. A first inventory data is received from a first wireless mobile communication device, and a second inventory data is received from a second wireless mobile communication device. The first inventory data and the second inventory data are compared to identify one or more matching data resources. In response to identifying one or more matching data resources, a matching inventory data that identifies the one or more matching data resources is sent to the first wireless mobile communication device. The matching inventory data enables the first wireless mobile communication device to access each of the one or more matching data resources stored on the second wireless mobile communication device.

Abstract: Some embodiments include a method of making available a synthetic fixed interest rate to a borrower under a loan and a variable interest rate to a lender of the loan. The method includes generating a settlement notice and sending the settlement notice. The settlement notice includes one of a notice of a first interest payment amount or a notice of a second interest payment amount. Further, when the settlement notice comprises the notice of the first interest payment amount, the method includes sending the first interest payment amount, and when the settlement notice comprises the notice of the second interest payment amount, the method includes receiving the second interest payment amount. Further still, the method includes receiving from the borrower a shared security interest in collateral securing the loan, and the shared security interest is shared with the lender. Other embodiments of related methods and systems are also provided.

Abstract: Some embodiments include a method of making available a synthetic variable interest rate to a borrower under a loan and a fixed interest rate to a lender of the loan. The method includes generating a settlement notice and sending the settlement notice. The settlement notice includes one of a notice of a first interest payment amount or a notice of a second interest payment amount. Further, when the settlement notice comprises the notice of the first interest payment amount, the method includes sending the first interest payment amount, and when the settlement notice comprises the notice of the second interest payment amount, the method includes receiving the second interest payment amount. Further still, the method includes receiving from the borrower a shared security interest in collateral securing the loan, and the shared security interest is shared with the lender. Other embodiments of related methods and systems are also provided.

Abstract: An apparatus and computer program product are disclosed for distributing inventory data for a distributed cache provided by a plurality of wireless mobile communication devices. A first inventory data is received from a first wireless mobile communication device, and a second inventory data is received from a second wireless mobile communication device. The first inventory data and the second inventory data are compared to identify one or more matching data resources. In response to identifying one or more matching data resources, a matching inventory data that identifies the one or more matching data resources is sent to the first wireless mobile communication device. The matching inventory data enables the first wireless mobile communication device to access each of the one or more matching data resources stored on the second wireless mobile communication device.

Abstract: A computer-implemented modeling system comprising a storage medium, an interface, an output device, and a processor. The storage medium to store executable instructions for providing a modeling environment using the system, the modeling environment supporting model development. The interface to receive an input instruction and create an executable instruction, where the user interaction represents the input instruction and instructs the modeling environment to perform one or more of: an analyzing operation, an editing operation, or a navigating operation. The output device to output at least one of: a tactile output representing tactile feedback, or a haptic output representing haptic feedback; and a processor to execute the executable instructions to provide the modeling environment, process the executable instruction using the modeling environment, and generate an output instruction, where the output instruction is used by an output device for generating the tactile output or the haptic output.

Abstract: A method for distributing inventory data for a distributed cache provided by a plurality of wireless mobile communication devices. A first inventory data is received from a first wireless mobile communication device, and a second inventory data is received from a second wireless mobile communication device. The first inventory data and the second inventory data are compared to identify one or more matching data resources. In response to identifying one or more matching data resources, a matching inventory data that identifies the one or more matching data resources is sent to the first wireless mobile communication device. The matching inventory data enables the first wireless mobile communication device to access each of the one or more matching data resources stored on the second wireless mobile communication device.

Abstract: In an embodiment, a plurality of graphical elements of a graphical model may be displayed on a display device. An indication of a graphical operation involving a first graphical element of the plurality of graphical elements may be received. The graphical operation when performed may establish a relationship between the first graphical element and one or more other graphical elements of the plurality of graphical elements that are compatible with the graphical operation. Two or more graphical elements of the plurality of graphical elements that are compatible with the graphical operation and one or more characteristics associated with the first graphical element may be identified. A visual indication may be provided on the display device. The visual indication may indicate that the identified plurality of graphical elements is compatible with the graphical operation.

Abstract: A method, apparatus and computer program product are disclosed for distributing inventory data for a distributed cache provided by a plurality of wireless mobile communication devices. A first inventory data is received from a first wireless mobile communication device, and a second inventory data is received from a second wireless mobile communication device. The first inventory data and the second inventory data are compared to identify one or more matching data resources. In response to identifying one or more matching data resources, a matching inventory data that identifies the one or more matching data resources is sent to the first wireless mobile communication device. The matching inventory data enables the first wireless mobile communication device to access each of the one or more matching data resources stored on the second wireless mobile communication device.

Abstract: There is provided a high throughput automated single molecule image collection and processing system that requires minimal initial user input. The unique features embodied in the present disclosure allow automated collection and initial processing of optical images of single molecules and their assemblies. Correct focus may be automatically maintained while images are collected. Uneven illumination in fluorescence microscopy is accounted for, and an overall robust imaging operation is provided yielding individual images prepared for further processing in external systems. Embodiments described herein are useful in studies of any macromolecules such as DNA, RNA, peptides and proteins. The automated image collection and processing system and method of same may be implemented and deployed over a computer network, and may be ergonomically optimized to facilitate user interaction.

Abstract: In an embodiment, a plurality of graphical elements of a graphical model may be displayed on a display device. An indication of a graphical operation involving a first graphical element of the plurality of graphical elements may be received. The graphical operation when performed may establish a relationship between the first graphical element and one or more other graphical elements of the plurality of graphical elements that are compatible with the graphical operation. Two or more graphical elements of the plurality of graphical elements that are compatible with the graphical operation and one or more characteristics associated with the first graphical element may be identified. A visual indication may be provided on the display device. The visual indication may indicate that the identified plurality of graphical elements is compatible with the graphical operation.

Abstract: There is provided a high throughput automated single molecule image collection and processing system that requires minimal initial user input. The unique features embodied in the present disclosure allow automated collection and initial processing of optical images of single molecules and their assemblies. Correct focus may be automatically maintained while images are collected. Uneven illumination in fluorescence microscopy is accounted for, and an overall robust imaging operation is provided yielding individual images prepared for further processing in external systems. Embodiments described herein are useful in studies of any macromolecules such as DNA, RNA, peptides and proteins. The automated image collection and processing system and method of same may be implemented and deployed over a computer network, and may be ergonomically optimized to facilitate user interaction.

Abstract: The present invention provides a method and apparatus for mounting a plurality of components, preferably optical components, with a device, such as a circuit board, to provide communication onto and off of the device. The apparatus includes a mount body having an interface wall, a first component mount fixed with the interface wall, wherein the first component mount extends out from the interface wall, and a second component mount fixed with the interface wall, wherein the second component mount extends out from the interface wall. The first component mount is configured to receive and secure a first optical component such that at least a portion of the first optical component extends out from the interface wall. The second component mount is configured to receive and secure a second optical component such that at least a portion of the second optical component extends out from the interface wall.