Abstract: The present disclosure provides SPNS2 inhibitor compounds according to Formula I and their pharmaceutically acceptable salts, and/or tautomers as described in the disclosure, and the disclosure provides their pharmaceutical compositions and methods of use in therapy.

Abstract: An assembly of a medical device may comprise an elevator configured to raise and lower in order to adjust an orientation of an instrument inserted through a working channel of the medical device. The elevator may include a magnet. The assembly also may include a sensing element configured to measure a magnetic field of the magnet and to output a signal indicative of a configuration of the elevator.

Abstract: A medical assembly may comprise: a substrate configured to be disposed in a body at a distal tip of a medical device; and a position sensing system, including a magnetic field sensor mounted to the substrate. The magnetic field sensor may be configured to provide a signal that indicates a position or orientation of the distal tip of the medical device. The medical assembly may further comprise at least one camera mounted to the substrate; and at least one lighting element mounted to the substrate.

Abstract: A medical assembly may comprise: a substrate configured to be disposed in a body at a distal tip of a medical device; and a position sensing system, including a magnetic field sensor mounted to the substrate. The magnetic field sensor may be configured to provide a signal that indicates a position or orientation of the distal tip of the medical device. The medical assembly may further comprise at least one camera mounted to the substrate; and at least one lighting element mounted to the substrate.

Abstract: A system for detecting a fault in a locking pin for use in an aircraft includes the locking pin; means for receiving a static air temperature; and a controller; wherein said locking pin comprises an internal heater element and at least one internal temperature sensor provided therein. The system also includes means for transmitting said measured temperature sensor information from said at least internal temperature sensor and said static air temperature information to said controller. The controller is configured to compare the static air temperature information with said locking pin temperature sensor information and determine if a difference between the measurements is above a static v. internal temperature threshold value.

Abstract: A coupling mechanism can be used to selectively secure two sections of telescopically engaged pipe in a fixed position relative to each other and provide a fluid (e.g., gas and/or liquid) seal between the coupling mechanism and the two pipes, regardless of whether the pipes are secured in the fixed position or are freely moveable relative to each other. The coupling mechanism can be used as part of a faucet assembly, which can include an adjustable faucet assembly including the telescopically engaged pipe.

Abstract: An apparatus configured to measure the output of a rotary actuator unit includes a rotary actuator unit. The unit includes a stationary portion, a rotating portion, and a main rotational axis (L) that runs in an axial direction from a first end of the rotary actuator unit to a second end of the rotary actuator unit. The first end is opposite the second end. The apparatus also includes a linear position sensor comprising a follower, a sensor, and a sensor arm, wherein the follower is attached to the sensor by sensor arm; and wherein the sensor is attached to the stationary portion. The apparatus also includes a follower track attached or formed in, or on, to the rotating portion. The follower track is aligned in the circumferential direction that is perpendicular to axial direction of the main rotational axis (L). The follower is configured to follow the follower track.

Abstract: A medical assembly may comprise: a substrate configured to be disposed in a body at a distal tip of a medical device; and a position sensing system, including a magnetic field sensor mounted to the substrate. The magnetic field sensor may be configured to provide a signal that indicates a position or orientation of the distal tip of the medical device. The medical assembly may further comprise at least one camera mounted to the substrate; and at least one lighting element mounted to the substrate.

Abstract: The present disclosure provides SPNS2 inhibitor compounds according to Formula (IA) and Formula (I), and their pharmaceutically acceptable salts, and/or tautomers as described in the disclosure, and the disclosure provides their pharmaceutical compositions and methods of use in therapy.

Abstract: An assembly of a medical device may comprise an elevator configured to raise and lower in order to adjust an orientation of an instrument inserted through a working channel of the medical device. The elevator may include a magnet. The assembly also may include a sensing element configured to measure a magnetic field of the magnet and to output a signal indicative of a configuration of the elevator.

Abstract: The present disclosure relates to an installation ready housing type pipe coupling for creating a sealed connection between coaxial groove ended pipes, a hold open clip for the coupling, and other modifications and improvements thereof. The coupling comprises a first and second housing segments creating a cavity, a gasket provided within the cavity, a first and second bolts and nuts connecting the hosing segments at opposite ends, and a hold open clip. The first nut is affixed to the first bolt. The second nut can be adjusted along the second bolt. The hold open clip helps to attach the two housing segments in the preassembled state while keeping the coupling open. The hold open clip may also indicate a proper installation of the coupling.

Abstract: The present disclosure provides SPNS2 inhibitor compounds according to Formula I and their pharmaceutically acceptable salts, and/or tautomers as described in the disclosure, and the disclosure provides their pharmaceutical compositions and methods of use in therapy.

Abstract: An apparatus configured to measure the output of a rotary actuator unit includes a rotary actuator unit. The unit includes a stationary portion, a rotating portion, and a main rotational axis (L) that runs in an axial direction from a first end of the rotary actuator unit to a second end of the rotary actuator unit. The first end is opposite the second end. The apparatus also includes a linear position sensor comprising a follower, a sensor, and a sensor arm, wherein the follower is attached to the sensor by sensor arm; and wherein the sensor is attached to the stationary portion. The apparatus also includes a follower track attached or formed in, or on, to the rotating portion. The follower track is aligned in the circumferential direction that is perpendicular to axial direction of the main rotational axis (L). The follower is configured to follow the follower track.

Abstract: A system for detecting a fault in a locking pin for use in an aircraft includes the locking pin; means for receiving a static air temperature; and a controller; wherein said locking pin comprises an internal heater element and at least one internal temperature sensor provided therein. The system also includes means for transmitting said measured temperature sensor information from said at least internal temperature sensor and said static air temperature information to said controller. The controller is configured to compare the static air temperature information with said locking pin temperature sensor information and determine if a difference between the measurements is above a static v. internal temperature threshold value.

Abstract: Disclosed are embodiments of a coupling mechanism that can be used to selectively secure two sections of telescopically engaged pipe in a fixed position relative to each other and provide a fluid (e.g., gas and/or liquid) seal between to the coupling mechanism and the two pipes, regardless of whether the pipes are secured in the fixed position or are freely moveable relative to each other. In some embodiments, the coupling mechanism can be used as part of a faucet assembly, which can include an adjustable faucet assembly including the telescopically engaged pipe.

Abstract: The present disclosure relates to an installation ready housing type pipe coupling for creating a sealed connection between coaxial groove ended pipes, a hold open clip for the coupling, and other modifications and improvements thereof. The coupling comprises a first and second housing segments creating a cavity, a gasket provided within the cavity, a first and second bolts and nuts connecting the hosing segments at opposite ends, and a hold open clip. The first nut is affixed to the first bolt. The second nut can be adjusted along the second bolt. The hold open clip helps to attach the two housing segments in the preassembled state while keeping the coupling open. The hold open clip may also indicate a proper installation of the coupling.

Abstract: A light assembly, comprising: a base; at least one electromagnetic radiation source mounted on the base; a cover located over the base, the cover being transparent to the electromagnetic radiation produced by the electromagnetic radiation source; and at least one photo detector, optically Isolated from the at least one electromagnetic radiation source, the at least one photo detector being configured to receive electromagnetic radiation conveyed by the cover.

Abstract: A light assembly, comprising: a base; at least one electromagnetic radiation source mounted on the base; a cover located over the base, the cover being transparent to the electromagnetic radiation produced by the electromagnetic radiation source; and at least one photo detector, optically Isolated from the at least one electromagnetic radiation source, the at least one photo detector being configured to receive electromagnetic radiation conveyed by the cover.