Abstract: The invention relates to methods of treating myeloid malignancies by administering compositions comprising V?1+ T cells.

Abstract: The invention relates to compositions comprising V?1+ T cells, for use in treating myeloid malignancies. The present invention also relates to methods of treatment using said compositions.

Abstract: The invention relates to methods of treating myeloid malignancies by administering compositions comprising V?1+T cells.

Abstract: Circuitry may be configured to identify a particular element position of a bit vector stored in a register, where a value of the element occupying the particular element position matches a first predetermined value, and determine an address value dependent upon the particular element position of the bit vector and a base address. The circuitry may be further configured to load data from a memory dependent upon the address value.

Abstract: Techniques are provided for exchanging dedicated hardware signals to manage a first-in first-out (FIFO). In an embodiment, a first processor initiates content transfer into the FIFO. The first processor activates a first hardware signal that is reserved for indicating that content resides within the FIFO. A second processor activates a second hardware signal that is reserved for indicating that content is accepted. The second hardware signal causes the first hardware signal to be deactivated. This exchange of hardware signals demarcates a FIFO transaction, which is mediated by interface circuitry of the FIFO.

Abstract: Exemplary methods for performing web service calls include receiving, from a first client application associated with a first thread, a first request to establish a first connection with a first service endpoint providing a first service, the first request including a first connection key. The methods further include in response to the first request, identifying a first stub manager object that corresponds to the first connection key and the first thread, the first stub manager object representing a first instance of a stub manager. The methods further include providing, exclusively to the first client application of the first thread, the first stub manager object, wherein the first client application of the first thread is to use the first stub manager object for communicating with the first service endpoint.

Abstract: Techniques are provided for exchanging dedicated hardware signals to manage a first-in first-out (FIFO). In an embodiment, a first processor initiates content transfer into the FIFO. The first processor activates a first hardware signal that is reserved for indicating that content resides within the FIFO. A second processor activates a second hardware signal that is reserved for indicating that content is accepted. The second hardware signal causes the first hardware signal to be deactivated. This exchange of hardware signals demarcates a FIFO transaction, which is mediated by interface circuitry of the FIFO.

Abstract: Techniques are provided for exchanging dedicated hardware signals to manage a first-in first-out (FIFO). In an embodiment, a first processor initiates content transfer into the FIFO. The first processor activates a first hardware signal that is reserved for indicating that content resides within the FIFO. A second processor activates a second hardware signal that is reserved for indicating that content is accepted. The second hardware signal causes the first hardware signal to be deactivated. This exchange of hardware signals demarcates a FIFO transaction, which is mediated by interface circuitry of the FIFO.

Abstract: Circuitry may be configured to identify a particular element position of a bit vector stored in a register, where a value of the element occupying the particular element position matches a first predetermined value, and determine an address value dependent upon the particular element position of the bit vector and a base address. The circuitry may be further configured to load data from a memory dependent upon the address value.

Abstract: Circuitry may be configured to identify a particular element position of a bit vector stored in a register, where a value of the element occupying the particular element position matches a first predetermined value, and determine an address value dependent upon the particular element position of the bit vector and a base address. The circuitry may be further configured to load data from a memory dependent upon the address value.

Abstract: Circuitry may be configured to identify a particular element position of a bit vector stored in a register, where a value of the element occupying the particular element position matches a first predetermined value, and determine an address value dependent upon the particular element position of the bit vector and a base address. The circuitry may be further configured to load data from a memory dependent upon the address value.

Abstract: Techniques are provided for exchanging dedicated hardware signals to manage a first-in first-out (FIFO). In an embodiment, a first processor initiates content transfer into the FIFO. The first processor activates a first hardware signal that is reserved for indicating that content resides within the FIFO. A second processor activates a second hardware signal that is reserved for indicating that content is accepted. The second hardware signal causes the first hardware signal to be deactivated. This exchange of hardware signals demarcates a FIFO transaction, which is mediated by interface circuitry of the FIFO.

Abstract: Provided herein are prognostic and diagnostic methods for predicting likelihood of clinical response of a subject having cancer to treatment with an immunotherapeutic agent. Also provided herein are methods for treating a subject having cancer with an immunotherapeutic agent after determining likelihood of clinical response of the subject to such treatment.

Abstract: The present invention provides a process for characterizing a glatiramer acetate related drug substance or drug product comprising the steps of: a) obtaining a batch of the glatiramer acetate related drug substance or drug product; b) immunizing a mammal with a predetermined amount of a glatiramer acetate related drug substance or drug product; c) preparing a culture of cells from the mammal of step b) at a predetermined time after immunization; d) incubating cells from the culture of step c) with a predetermined amount of the glatiramer acetate drug related substance or drug product of step a); and e) determining the level of expression of at least one gene disclosed herein or determining the level of biological activity of the cells of step c) as disclosed herein, thereby characterizing the glatiramer acetate related drug substance or drug product of step a).

Abstract: The invention provides nucleic acids comprising a nucleotide sequence encoding programmed death ligand-1 (PD-L1) and a nucleotide sequence encoding a fusion protein comprising thymidylate kinase (TMPK) or a variant thereof and a cell surface marker or a variant thereof. Recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and kits relating to the nucleic acids are disclosed. Methods of treating or preventing a disease in a host and methods of suppressing an immune system in a host are also disclosed.

Abstract: Methods for generating highly enriched Th1/Tcl and Th2/Tc2 functions are described. In particular, the generation of these functions are attained by the addition of an immune suppression drug, rapamycin or a rapamycin derivative compound. In addition to enhanced purity of T cell function, the T cells generated in rapamycin also express molecules that improve immune T cell function such as CD28 and CD62L. Such rapamycin generated functional T cell subsets may have application in the prevention or treatment of GVHD after allogeneic hematopoietic stem cell transplantation, the treatment of autoimmunity, or the therapy of infection or cancer.

Abstract: A method is provided for producing a population of CD8+ Tc1 and/or Tc2 lymphocytes ex vivo. The method includes stimulating a population of T cells obtained from a subject by contacting the population with an anti-CD3 monoclonal antibody and an antibody that specifically binds to a T cell costimulatory molecule in the presence of a Tc1 or Tc2 supportive environment to form a stimulated population of T cells. The stimulated population of CD8+ T cells is allowed to proliferate in a Tc1 or Tc2 supportive environment. Purified populations of Tc1 and Tc2 cells are disclosed herein, as are methods for their use.