Abstract: A bioactive filter has at least one layer comprising at least one transitional element or compound (e.g., iron, cobalt, nickel, zinc, etc.). The bioactive filter deactivates a virus based on the charge of the transitional element incorporated into the filter design. The transitional element may be found in the at least one layer in nanoparticle form. Upon interdiction of the virus in the filter, the transitional element mimics the charge or shape of the ACE-2 receptors and the virus falsely attempts to infect the transitional element contained in the at least one layer of the bioactive filter, thereby deactivating the virus.

Abstract: The invention provides an implantable medical device comprising a fibrous polymer body comprising a plurality of electrospun poly(urethane) fibers, a support filament wrapped around the body, an outer layer around the filament for adhering the filament to the body, the outer layer comprising a plurality of electrospun poly(urethane) fibers, and a polymer primer coating at least the fibers of the body. The polymer primer comprises poly(lactide) and is attached to a heparin residue through a link.

Abstract: The invention provides an implantable medical device comprising a fibrous polymer body comprising a plurality of electrospun poly(urethane) fibers, a support filament wrapped around the body, an outer layer around the filament for adhering the filament to the body, the outer layer comprising a plurality of electrospun poly(urethane) fibers, and a polymer primer coating at least the fibers of the body. The polymer primer comprises poly(lactide) and is attached to a heparin residue through a link.

Abstract: The invention provides an implantable medical device comprising a fibrous polymer body comprising a plurality of electrospun poly(urethane) fibers, a support filament wrapped around the body, an outer layer around the filament for adhering the filament to the body, the outer layer comprising a plurality of electrospun poly(urethane) fibers, and a polymer primer coating at least the fibers of the body. The polymer primer comprises poly(lactide) and is attached to a heparin residue through a link.

Abstract: The invention provides an implantable medical device comprising a fibrous polymer body comprising a plurality of electrospun poly(urethane) fibers, a support filament wrapped around the body, an outer layer around the filament for adhering the filament to the body, the outer layer comprising a plurality of electrospun poly(urethane) fibers, and a polymer primer coating at least the fibers of the body.

Abstract: An ePTFE vascular graft having a smooth PTFE luminal surface which is substantially non-adhesive to occlusive blood components. Preferably the graft is a longitudinally extruded and expanded ePTFE tube of about 10-30 microns mean fibril length and is provided with a luminal surface covering of an ePTFE film of small mean fibril length (5 microns of less) which provides the smooth luminal PTFE surface. The graft is anticipated to be particularly effective as a small diameter graft (6 mm or smaller). It is anticipated to have utility as a conventional vascular graft, as a cardiovascular patch and as an intraluminal vascular graft and as a covering for stents.