Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: A bulk fluid wash module for an automated treatment apparatus for treating tissue samples disposed on slides, the bulk fluid wash module comprising: a body; a cavity disposed in the body, the cavity configured to receive a plurality of bulk fluids dispensed from a plurality of probes of a bulk fluid robot of the automated treatment apparatus, whereby the plurality of probes are configured to dispense the bulk fluids to the slides and to the cavity; and a scavenger port disposed in the body, the scavenger port in fluid communication with the cavity and configured to remove the bulk fluids from the cavity.

Abstract: Disclosed is a bore measurement unit having an elongate main body with first and second ends. A first adjustment mechanism is disposed near the first end and a second adjustment mechanism is disposed near said second end. The adjustment mechanisms expand or contract, through triangulating arms, to relative diameters, such that when the unit is inserted into a hollow bore it may be centered therein. A measuring portion of the unit measures the internal diameter of the bore. The measuring unit includes at least one sensor and preferably takes more than three readings at each distance of insertion to formulate a best fit circle of the inner bore diameter.

Abstract: Disclosed is a bore measurement unit having an elongate main body with first and second ends. A first adjustment mechanism is disposed near the first end and a second adjustment mechanism is disposed near said second end. The adjustment mechanisms expand or contract, through triangulating arms, to relative diameters, such that when the unit is inserted into a hollow bore it may be centered therein. A measuring portion of the unit measures the internal diameter of the bore. The measuring unit includes at least one sensor and preferably takes more than three readings at each distance of insertion to formulate a best fit circle of the inner bore diameter.

Abstract: A co-packaged product and containers for co-packaging two different substrates is disclosed. The co-packaged product comprises a first substrate wound into a roll having an interior space, and a second substrate is located within at least a portion of the interior space. In one embodiment, a paper towel roll has a wet wipe container located within the core of the paper towel.

Abstract: A co-packaged product and containers for co-packaging two different substrates is disclosed. The co-packaged product comprises a first substrate wound into a roll having an interior space, and a second substrate is located within at least a portion of the interior space. In one embodiment, a paper towel roll has a wet wipe container located within the core of the paper towel.

Abstract: A co-packaged product and containers for co-packaging two different substrates is disclosed. The co-packaged product comprises a first substrate wound into a roll having an interior space, and a second substrate is located within at least a portion of the interior space. In one embodiment, a paper towel roll has a wet wipe container located within the core of the paper towel.

Abstract: An advertising system for displaying adaptive advertisements that can change the displayed content in response to external inputs can be used in public places such as transit stations, arenas, stadiums, retail stores, and squares. The advertising system can also be deployed in transit vehicles. The advertisements make use of a decision engine to select from a plurality of advertising scenarios to generate the content that is rendered on displays. The system has a processor that executes the decision engine and provides the decision engine with the external inputs, such as time of day, weather conditions and forecast, current, past or next transit station, required to select one of the stored advertising scenarios. These input scenarios can be either stored by the system or obtained in real-time. A system for distributing advertisement content to displays for playback based on the correlation between the attributes of the Content, attributes of the displays, and other factors.

Abstract: Described herein is a system and method for hydrothermal mineral extraction wherein the conditions surrounding hydrothermal systems are used advantageously to extract a mineral-rich brine. Specifically, hydrothermal fluid from ocean based or saline based hydrothermal systems contain a variety of minerals suspended in supercritical water and can be drawn up a well. As long as the water remains a supercritical fluid, the minerals remain largely in solution; however, as the hydrothermal fluid moves away from the this state, the water can cool and exit the supercritical state, causing the depositing or scaling of minerals along the walls of the well pipe. In the instant invention, non-supercritical conditions are rapidly induced onto the hydrothermal fluid such that the brine containing the minerals rapidly precipitates and forms a slurry which is then isolated from the water. Another aspect regards altering the chemistry of the fluid to precipitate the minerals.

Abstract: An advertising system for displaying adaptive advertisements that can change the displayed content in response to external inputs can be used in public places such as transit stations, arenas, stadiums, retail stores, and squares. The advertising system can also be deployed in transit vehicles. The advertisements make use of a decision engine to select from a plurality of advertising scenarios to generate the content that is rendered on displays. The system has a processor that executes the decision engine and provides the decision engine with the external inputs, such as time of day, weather conditions and forecast, current, past or next transit station, required to select one of the stored advertising scenarios. These input scenarios can be either stored by the system or obtained in real-time.

Abstract: A mechanism for automating, in large part or in whole, the process of establishing a resource grid is provided. This mechanism, which may take the form of a grid establishment component (GEC), is communicatively coupled to a plurality of nodes, wherein each node provides zero or more resources. After the GEC is coupled to the nodes, the GEC determines which of the nodes to include in a resource grid. The nodes that are selected to be included in the resource grid are referred to as grid nodes. After the grid nodes are selected, the GEC proceeds to establish the resource grid by configuring each grid node to enable it to participate as part of the resource grid. In addition, the GEC establishes one or more grid masters to manage access to the resources provided by the grid nodes. Once the grid nodes are configured, and one or more grid masters are established, the resource grid is ready for regular operation.

Abstract: A co-packaged product and containers for co-packaging two different substrates is disclosed. The co-packaged product comprises a first substrate wound into a roll having an interior space, and a second substrate is located within at least a portion of the interior space. In one embodiment, a paper towel roll has a wet wipe container located within the core of the paper towel.