Abstract: The invention relates to a pharmaceutical product comprising an allergen extract or an allergoid thereof for the treatment and/or prevention of allergy and allergic asthma caused by house dust mites, which extract comprises at least one extract of mite bodies selected from the following groups a)-b): a) An extract of Der p mite bodies, and b) An extract of Der f mite bodies, and at least one extract of mite cultures selected from the following groups c)-g): c) An extract of Der p faecal particles, d) An extract of Der f faecal particles, e) An extract of Der f whole mite culture, f) An extract of an Der p whole mite culture, and g) a combination of extracts c) to f).

Abstract: The invention relates to a pharmaceutical product comprising an allergen extract or an allergoid thereof for the treatment and/or prevention of allergy and allergic asthma caused by house dust mites, which extract comprises at least one extract of mite bodies selected from the following groups a)-b): a) An extract of Der p mite bodies, and b) An extract of Der f mite bodies, and at least one extract of mite cultures selected from the following groups c)-g): c) An extract of Der p faecal particles, d) An extract of Der f faecal particles, e) An extract of Der f whole mite culture, f) An extract of an Der p whole mite culture, and g) a combination of extracts c) to f).

Abstract: A release device for releasing a flowable preparation includes an electrical energy source, a control unit connected to the energy source, a sensor unit, a release element and an acoustic transducer. The sensor unit is a piezoelectric element suitable for picking up sound waves and/or structure-borne noise from the surrounding environment and converting them into a sensor signal which is converted in the control unit into a control signal for the release element. The release element is the same piezoelectric element and is supplied with electrical signals from the control unit and sprays at least one first preparation from at least one first container. The acoustic transducer is the same piezoelectric element and is supplied with electrical signals from the control unit, which electrical signals are converted by the piezoelectric element into audible acoustic signals in a frequency range of 20 Hz to 20 kHz.

Abstract: A method of operating a toilet freshener includes the step of flushing water flow through a toilet bowl within a flushing water period [t1-t2], in which t1 represents the start of flush water flow and t2 the end of flush water flow. A sensor unit detects triggering of a flush water stream through the toilet bowl within the flushing water period [t1-t2] at a time ts. A sensor signal, which represents triggering of the flush water stream, is sent to a control unit. The sensor signal is converted, using the control unit, into a control signal for the release element, in response thereto, to release preparation from the container into the interior of the toilet bowl, release of the preparation from the container taking place with a time delay ?t after detection of the flush stream by the sensor unit and continuing for a first preparation release period ?t1.

Abstract: The invention relates to a pharmaceutical product comprising an allergen extract or an allergoid thereof for the treatment and/or prevention of allergy and allergic asthma caused by house dust mites, which extract comprises at least one extract of mite bodies selected from the following groups a)-b): a) An extract of Der p mite bodies, and b) An extract of Der f mite bodies, and at least one extract of mite cultures selected from the following groups c)-g): c) An extract of Der p faecal particles, d) An extract of Der f faecal particles, e) An extract of Der f whole mite culture, f) An extract of an Der p whole mite culture, and g) a combination of extracts c) to f).

Abstract: A release device, such as a toilet freshener that releases at least one preparation into the interior of a toilet bowl, comprises a dispenser, at least one container connected to the dispenser for storing at least one preparation, a release element for releasing preparation, a line connecting the release element and the container in communicating manner, a sensor unit capable of detecting vibrations, and a fastening means for detachably fixing the dispenser to the rim of a toilet bowl. In a preferred embodiment, the fastening means rests at least in part on the toilet bowl and is configured to pick up vibrations, such as structure-borne noise, from the toilet bowl and transmit them to the sensor unit.

Abstract: The application relates to a release device, in particular toilet freshener, for releasing at least one preparation into the interior of a toilet bowl comprising a dispenser, at least one container connected to the dispenser for storing at least one preparation, a release element for releasing preparation, in particular into the interior of a toilet bowl, the release element being connected in communicating manner to the container via a line and the bottom of the container being arranged above the release orifice of the release element in the direction of gravity, such that a difference in level ?h is formed between the bottom of the container and the release orifice of the release element.

Abstract: A toilet freshener for releasing a preparation into a toilet bowl includes a dispenser, at least one container couplable with the dispenser for storing the preparation, a release element for releasing preparation into the toilet bowl and connected in communicating manner to the container via a line so that the bottom of the container is arranged above the release orifice of the release element in the direction of gravity, such that a difference in level is formed between the bottom of the container and the release orifice of the release element, and a pin connected to the line, which interacts with the couplable container such that, during coupling of the container with the dispenser, the pin displaces a volume of preparation in the container, whereby a pressure is produced in the container, which pressure conveys the preparation over the difference in level into the line.

Abstract: The invention provides means and methods for an improved production of glycosylated recombinant proteins in lower eukaryotes, specifically the production of human-like complex or hybrid glycosylated proteins in yeast. The invention provides genetically modified eukaryotic host cells capable of producing glycosylation optimized proteins useful as immunoglobulins and other therapeutic proteins, and provides cells capable of producing glycoproteins having glycan structures similar to glycoproteins produced in human cell. The invention further provides proteins with human-like glycan structures and novel compositions thereof producible by these modified cells.

Abstract: The invention relates to a pharmaceutical product comprising an allergen extract or an allergoid thereof for the treatment and/or prevention of allergy and allergic asthma caused by house dust mites, which extract comprises at least one extract of mite bodies selected from the following groups a)-b): a) An extract of Der p mite bodies, and b) An extract of Der f mite bodies, and at least one extract of mite cultures selected from the following groups c)-g): c) An extract of Der p faecal particles, d) An extract of Der f faecal particles, e) An extract of Der f whole mite culture, f) An extract of an Der p whole mite culture, and g) a combination of extracts c) to f).

Abstract: The application relates to a release device, in particular toilet freshener, for releasing at least one preparation into the interior of a toilet bowl comprising a dispenser, at least one container connected to the dispenser for storing at least one preparation, a release element for releasing preparation, in particular into the interior of a toilet bowl, the release element being connected in communicating manner to the container via a line and the bottom of the container being arranged above the release orifice of the release element in the direction of gravity, such that a difference in level ?h is formed between the bottom of the container and the release orifice of the release element.

Abstract: A release device, such as a toilet freshener that releases at least one preparation into the interior of a toilet bowl, comprises a dispenser, at least one container connected to the dispenser for storing at least one preparation, a release element for releasing preparation, a line connecting the release element and the container in communicating manner, a sensor unit capable of detecting vibrations, and a fastening means for detachably fixing the dispenser to the rim of a toilet bowl. In a preferred embodiment, the fastening means rests at least in part on the toilet bowl and is configured to pick up vibrations, such as structure-borne noise, from the toilet bowl and transmit them to the sensor unit.

Abstract: A method of operating a toilet freshener includes the step of flushing water flow through a toilet bowl within a flushing water period [t1-t2], in which t1 represents the start of flush water flow and t2 the end of flush water flow. A sensor unit detects triggering of a flush water stream through the toilet bowl within the flushing water period [t1-t2] at a time ts. A sensor signal, which represents triggering of the flush water stream, is sent to a control unit. The sensor signal is converted, using the control unit, into a control signal for the release element, in response thereto, to release preparation from the container into the interior of the toilet bowl, release of the preparation from the container taking place with a time delay ?t after detection of the flush stream by the sensor unit and continuing for a first preparation release period ?t1.

Abstract: A toilet freshener for releasing a preparation into a toilet bowl includes a dispenser, at least one container couplable with the dispenser for storing the preparation, a release element for releasing preparation into the toilet bowl and connected in communicating manner to the container via a line so that the bottom of the container is arranged above the release orifice of the release element in the direction of gravity, such that a difference in level is formed between the bottom of the container and the release orifice of the release element, and a pin connected to the line, which interacts with the couplable container such that, during coupling of the container with the dispenser, the pin displaces a volume of preparation in the container, whereby a pressure is produced in the container, which pressure conveys the preparation over the difference in level into the line.

Abstract: The invention improves glycoprotein production and protein glycosylation engineering in eukaryotes, specifically the production of human-like complex or hybrid glycosylated proteins in lower eukaryotes such as yeasts. The invention provides glycosylation modified eukaryotic host cells capable of producing glycosylation optimized proteins useful as immunoglobulins and other therapeutic proteins, and provides cells capable of producing glycoproteins having glycan structures similar to glycoproteins produced in human cell. The invention further provides proteins with human-like glycan structures and novel compositions thereof producible by these cells.

Abstract: The invention relates to a method for treating a mineral filler by means of a polydialkylsiloxane and a fatty acid, the hydrophobic fillers thus obtained, and the application thereof in polymers for the manufacture of films and notably “breathable” films.

Abstract: The invention relates to a method for treating a mineral filler by means of a polydialkylsiloxane and a fatty acid, the hydrophobic fillers thus obtained, and the application thereof in polymers for the manufacture of films and notably breathable films.

Abstract: A method of manufacturing a measuring tube for an electromagnetic flow sensor includes the steps of filling a material to be sintered into a lumen of a support tube, sintering the material within the lumen to obtain an open-pored reinforcing body of the measuring tube, and impregnating the open-pored reinforcing body obtained by the step of sintering the material within the lumen at least partially with a liquid insulating material and solidifying the insulating material to obtain a liner of the measuring tube.

Abstract: The invention relates to a method for treating a mineral filler by means of a polydialkylsiloxane and a fatty acid, the hydrophobic fillers thus obtained, and the application thereof in polymers for the manufacture of films and notably “breathable” films.

Abstract: A method and a device for making catalyst containers preparing, on a single semi-automatic production line, a station (1), at least a monolith enclosing the monolith with an insulating mat and bonding the insulating mat on the monolith; then slipping and automatically positioning the assembly obtained, in a precut tube, into a mounting and positioning assembly (2); etching the tube in an etching station (3); then transferring it into specific elements (5) for retaining, clamping and driving it in rotation; inserting an insulating cone at stations (5) dispensing and installing insulation cones; heating simultaneously the ends of the precut tube at a heating installation (6) maintaining the temperature at the ends to be deformed; deforming the ends, after a predetermined temperature is reached using a device with deforming rollers (7), while maintaining the forming temperature; extracting and evacuating the resulting container after the floturning and spinning process, towards a continuous cooling device (8), t