Abstract: The present invention relates in general to an inhibitor of a glutaminyl peptide cyclotransferase-like protein (QPCTL), and the use thereof for the treatment and/or prevention of an inflammatory disease or disorder selected from the group consisting of (a) chronic and acute inflammations, e.g. rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis; (b) other inflammatory diseases, e.g. neuropathic pain, graft rejection/graft failure/graft vasculopathy, HIV infections/AIDS, gestosis, tuberous sclerosis, Guillain-Barré syndrome, chronic inflammatory demyelinizing polyradiculoneuropathy and multiple sclerosis; (c) neuroinflammation; and (d) neurodegenerative diseases, e.g. mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down Syndrome, Familial British Dementia, and Familial Danish Dementia, which may result from neuroinflammation.

Abstract: The present invention relates in general to an inhibitor of a glutaminyl peptide cyclotransferase-like protein (QPCTL), and the use thereof for the treatment and/or prevention of an inflammatory disease or disorder selected from the group consisting of (a) chronic and acute inflammations, e.g. rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis; (b) other inflammatory diseases, e.g. neuropathic pain, graft rejection/graft failure/graft vasculopathy, HIV infections/AIDS, gestosis, tuberous sclerosis, Guillain-Barré syndrome, chronic inflammatory demyelinising polyradiculoneuropathy and multiple sclerosis; (c) neuroinflammation; and (d) neurodegenerative diseases, e.g. mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down Syndrome, Familial British Dementia, and Familial Danish Dementia, which may result from neuroinflammation.

Abstract: The present invention discloses a method for therapeutically treating an animal, including a human, for psychosomatic, depressive and neuropsychiatric diseases, such as anxiety, depression, insomnia, schizophrenia, epilepsy, spasm and chronic pain. Administration of a suitable attractin inhibitor causes the reduction of activity in the enzyme attraction or in isoforms thereof in the brain of mammals and leads as a causal consequence to a reduced degradation of the neuropeptide Y (NPY) and similar substrates. Such treatment will result in a reduction or delay in the decrease of the concentration of functionally active neuronal NPY (1-36). As a consequence of the resulting enhanced stability of the endogenous NPY (1-36), NPY activity is prolonged thereby resulting among other things in functionally active NPY Y1 receptor activity thereby facilitating antidepressive, anxiolytic, analgesic, t antihypertension and other neurological effects.

Abstract: Downstream of the last roller pair of a drafting frame for a spinning machine, the roving is condensed in a fiber-bundling zone having a belt with perforations to which suction is applied. Another belt converges toward the belt with the perforations and engages the roving at a nip spaced from the nip formed by the last roller pair of the drafting frame so that the wedge-shaped converging of the two belts promotes the compacting or condensing action.

Abstract: Downstream of the last roller pair of a drafting frame for a spinning machine, the roving is condensed in a fiber-bundling zone having a belt with perforations to which suction is applied. Another belt converges toward the belt with the perforations and engages the roving at a nip spaced from the nip formed by the last roller pair of the drafting frame so that the wedge-shaped converging of the two belts promotes the compacting or condensing action.

Abstract: A reserve-surface cleaning apparatus is used in combination with a ring-spinning machine having a longitudinally extending row of spindles each adapted to hold a roving sleeve and each formed below the respective sleeve with a respective reserve winding area and a longitudinally extending frame extending along a back side of the row and a service area extending along a front side of the row. The cleaning system has a guide rail extending on the frame longitudinally along the back side of the row of spindles, a cleaner carriage displaceable longitudinally along the rail past the spindles, and a drive for displacing the cleaner carriage longitudinally along the rail past the spindles. A set of tools on the cleaner carriage strips roving from the reserve surfaces as the cleaner carriage passes same.

Abstract: In a ring-spinning or -twisting machine a longitudinal row of upright and normally rotating spindles mounted on a common support beam each have a lower reserve surface below a sleeve normally carried on the spindle. An apparatus for clearing roving wound on the surface has a guide rail extending longitudinally along a back side of the beam adjacent the spindles, a carriage displaceable along the rail past the spindles, and a drive including a longitudinally extending drive element secured to the carriage for displacing same longitudinally along the rail past the spindles. A roving-cutting element is fixed on the carriage engageable immediately adjacent the spindles between the respective lower reserve surfaces and sleeves and a roving-clearing element is fixed on the carriage below the cutting element and engageable immediately adjacent the lower reserve surfaces of the spindles.