Abstract: A base station, a wireless device and methods therein for supporting radio communication, wherein the base station employs carrier aggregation with multiple carriers serving a primary cell, PCell, and at least one secondary cell, SCell. The base station signals (3:3) an SCell status to the wireless device, the SCell status indicating whether the at least one SCell will be in active state where the base station transmits downlink signals on a carrier serving the at least one SCell, or in inactive state where the base station does not transmit downlink signals on the carrier serving the at least one SCell. Thereby, the wireless device can adapt its behaviour depending on the signalled SCell status, e.g. by turning off its receiver and not perform any signal measurements when the SCell is in inactive state.

Abstract: Embodiments include methods for a user equipment (UE) configured to operate in a radio access network (RAN). Such methods include receiving, from a radio node in the RAN, a new feedback indicator (NFI) that indicates whether acknowledgement signaling previously scheduled for transmission by the UE was received by the radio node. The acknowledgement signaling is associated with one or more first downlink (DL) hybrid ARQ (HARQ) processes. Such methods include, when the NFI indicates the acknowledgement signaling was not received by the RAN node, selecting a first HARQ codebook to be used for encoding the acknowledgement signaling together with further acknowledgement signaling associated with one or more second DL HARQ processes. Such methods include, using the selected first HARQ codebook, encoding the acknowledgement signaling and the further acknowledgement signaling to obtain first encoded information and transmitting the first encoded information to the radio node via an uplink (UL) channel.

Abstract: A personal care implement includes a treatment device having a longitudinal axis and including a treatment portion having at least one treatment element; a connection portion having a main body and a first resilient snap attachment protruding from the main body, the main body formed of a first material having a first hardness and the first resilient snap attachment formed of a second material having a second hardness, the first hardness being greater than the second hardness; and the treatment device is alterable between: (1) a detached state; and (2) an assembled state in which the treatment device is detachably coupled to a grip section such that the first resilient snap attachment cooperates with and engages a first engagement portion of the grip section to secure the treatment device to the grip section.

Abstract: An electrode tip for an implantable cardiac electrode, wherein the electrode tip comprises a housing having an electrode lead feed section, an electrode lead receiving section and a sealing element arranged between the electrode lead feed section and the electrode lead receiving section. The sealing element serves for sealing the electrode lead feed section in a fluid tight manner against the electrode lead receiving section, when an electrode lead is arranged within the electrode lead feed section and the electrode lead receiving section and is surrounded by the sealing element. According to an aspect of the invention, the sealing element consists of an injection-moldable material and constitutes a non-removable sealing portion forming an integral part of the housing.

Abstract: The invention provides methods of synthesizing a product DNA molecule having a desired and/or defined sequence. The methods involve assembling oligonucleotide members of a library that contains less than 20,000 members that can be assembled into all possible DNA sequences using the methods provided herein. Also disclosed are kits containing a library of 20,000 or less oligonucleotide members, where the oligonucleotide members in the library can be assembled into every possible polynucleotide sequence. Further disclosed are oligonucleotide libraries having less than 20,000 defined locations and having an oligonucleotide library member at each location, and the oligonucleotide library members can be assembled into every possible polynucleotide sequence.

Abstract: An implantable cardiac electrode comprising an electrode lead and an electrode tip, wherein the electrode tip comprises a housing and a fixation screw received within the housing, wherein the fixation screw is electrically conductive connected to the electrode lead and serves for fixing the electrode tip within cardiac tissue. The housing comprises a first element and a second element, wherein the first element has a sleeve-like shape and defines a receiving space for the fixation screw, wherein the second element is at least partially inserted into the receiving space so that the first element overlaps the second element in an overlapping area, wherein the first element and the second element are bonded together in the overlapping area, wherein the first element comprises a first material being transparent for light having a first wavelength, wherein the second element comprises a second material that is absorbing for light having the first wavelength.

Abstract: A rapid and automatic virus imaging and analysis system includes (i) electron optical sub-systems (EOSs), each of which has a large field of view (FOV) and is capable of instant magnification switching for rapidly scanning a virus sample; (ii) sample management sub-systems (SMSs), each of which automatically loads virus samples into one of the EOSs for virus sample scanning and then unloads the virus samples from the EOS after the virus sample scanning is completed; (iii) virus detection and classification sub-systems (VDCSs), each of which automatically detects and classifies a virus based on images from the EOS virus sample scanning; and (iv) a cloud-based collaboration sub-system for analyzing the virus sample scanning images, storing images from the EOS virus sample scanning, and storing and analyzing machine data associated with the EOSs, the SMSs, and the VDCSs.

Abstract: Described herein are systems and methods for point cloud alignment with a floor plan or a video stream of an environment. The systems and method comprise overlaying a graphical representation of a point cloud onto an image of the floor plan and the video stream. The systems and methods further comprise aligning the graphical representation of the point cloud and the image of the floor plan with the video stream using a point alignment. The systems and methods further comprise displaying an update of the graphical representation based at least in part on a further point alignment or a movement alignment.

Abstract: The disclosure relates to the use of biomarkers for predicting the response to cancer (e.g., melanoma) treatments, for selecting a treatment for a cancer patient (e.g., using targeted therapy, e.g., using an agent targeting BRAF and/or an agent targeting MEK in combination with an immuno-oncology therapy (e.g., an anti-PD-1 therapy)), for stratifying cancer patients into different treatment groups, for treating cancer patients, and for predicting clinical outcome in cancer.

Abstract: A base station (300), a wireless device (302) and methods thereinfor supporting radio communication, wherein the base station (300) employs carrier aggregation with multiple carriers serving a primary cell, PCell, and at least one secondary cell, SCell. The base station (300) signals (3:3) an SCell status to the wireless device (302), the SCell status indicating whether the at least one SCell will be in active state where the base station (300) transmits downlink signals on a carrier serving the at least one SCell, or in inactive state where the base station (300) does not transmit downlink signals on the carrier serving the at least one SCell. Thereby, the wireless device (302) can adapt its behaviour depending on the signalled SCell status, e.g. by turning off its receiver and not perform any signal measurements when the SCell is in inactive state.

Abstract: The invention provides methods of assembling a DNA molecule having a desired sequence. The methods involve contacting a DNA ligase with a plurality of short oligonucleotides to be assembled and performing the ligase chain reaction to thereby generate a set of polynucleotides. Oligonucleotides in the plurality overlap with and are complementary to a sequence of at least one other oligonucleotide in the plurality, and at least 50% of the oligonucleotides in the plurality are 6-30 nucleotides in length. The set of polynucleotides produced are contacted with a DNA polymerase and dNTPs in a mixture to join the set of polynucleotides and thereby create a DNA molecule having a desired sequence by polymerase chain assembly. The method allows for production of oligonucleotides of any length having very high sequence fidelity to a desired sequence.

Abstract: The scheduling flexibility of CSI reference signals enables time and frequency synchronization using multiple non-zero CSI-RSs transmitted in the same subframe, or using CSI-RSs transmitted in the same subframe with other synchronization signals. Also, multiple synchronization signals may be scheduled in the same subframe to enable fine time and frequency synchronization without cell-specific reference signals.

Abstract: The invention provides methods of synthesizing a product DNA molecule having a desired and/or defined sequence. The methods involve annealing at least one long oligonucleotide and at least one short oligonucleotide to at least one anchor strand having a sequence at least partially complementary to the at least one long and at least one short oligonucleotide. The invention also provides methods of synthesizing DNA molecules by assembling oligonucleotide members of a library that contains less than 20,000 members that can be assembled into all possible DNA sequences.

Abstract: A system comprising one or more processors and one or more non-transitory computer-readable media storing computing instructions, that when executed on the one or more processors, cause the one or more processors, to perform functions comprising: receiving, by an application programing interface (API), a change request for a route plan, wherein the change request is subject to a scenario specification and a load feasibility specification; determining an updated route plan based on whether the change request for the route plan is a feasible route based on the scenario specification and the load feasibility specification, and the route stop time is the route start time is flexible; and outputting the updated route plan and, when the route stop time is flexible, outputting the route start time. Other embodiments are disclosed.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating sickle cell disease (SCD) are described.

Abstract: The disclosed embodiments relate to a method performed by an apparatus and also relate to an apparatus. The method includes transmitting to a communication device a burst including a subframe; receiving from the communication device a HARQ values associated with the subframe; and determining a random backoff contention window size based on the received HARQ values and also based on previously unused HARQ feedbacks. The apparatus is configured to perform the method steps described above.

Abstract: A method and apparatus is disclosed for interfacing an asynchronous network with a synchronous network and in particular for efficiently utilizing available bandwidth of a synchronous network transmit opportunity. In one embodiment asynchronous traffic arrives via an asynchronous network at a network device, such as a switch, for transmission over a synchronous network. The traffic is parsed into cells and after switching, a reassembly unit is provided for processing one or more cells buckets. Write operations occur based on an ingress pointer while read operations are controlled by an egress pointer. Upon occurrence of a transmit opportunity on the synchronous network, the entire bandwidth of the transmit opportunity is utilized by loading awaiting cells from bucket memory on to the synchronous network. Sufficient cells are stored in memory between the memory locations identified by the ingress pointer and the egress pointer to insure total utilization of transmit opportunity bandwidth.

Abstract: System and method for dynamically altering bandwidth allocation to each region serviced by a network. Each region is allocated an initial estimated bandwidth on the network and compares instantaneous demand against the allocation. When demand falls below the allocation, the region releases bandwidth so other regions can take advantage of that bandwidth. When demand exceeds the allocation, the region takes advantage of bandwidth released by other regions.

Abstract: Communication circuitry is comprised of processing circuitry, parallel channels, and crossbar integrated circuits. The processing circuitry exchanges the communications between communication links and the parallel channels. The parallel channels transfer the communications in parallel with a clock signal. The crossbar integrated circuits receive the communications and the clock signal over the parallel channels, switch the communications based on the clock signal, and transfer the switched communications to the parallel channels.