Abstract: A biocompatible implant for continuous in vivo release of a neurotoxin over a treatment period extending from one month to five years. The implant can be made of casting a solution of a polymer, such as an ethyl vinyl acetate copolymer and the neurotoxin. The neurotoxin can be a botulinum toxin.

Abstract: An intraocular lens for implantation in an eye comprising an optic configured so that the optic can be deformed to permit the intraocular lens to be passed through an incision into the eye. A peripheral zone circumscribes the optical zone of the optic and one or more fixation members coupled to the peripheral zone and extending outwardly from the peripheral zone to retain the optic in the eye are provided. In one embodiment the fixation member or members are located so that the optical zone is free of such member or members. The peripheral zone preferably has a maximum axial thickness which is larger than the maximum axial thickness of the periphery of the optical zone.

Abstract: A biocompatible implant for continuous in vivo release of a neurotoxin over a treatment period extending from one month to five years. The implant can be made of casting a solution of a polymer, such as an ethyl vinyl acetate copolymer and the neurotoxin. The neurotoxin can be a botulinum toxin.

Abstract: A biocompatible implant for continuous in vivo release of a neurotoxin over a treatment period extending from one month to five years. The implant can be made of casting a solution of a polymer, such as an ethyl vinyl acetate copolymer and the neurotoxin. The neurotoxin can be a botulinum toxin.

Abstract: Apparatus for inserting intraocular lenses (IOLs) into eyes include a hollow tube including a material and having an interior wall defining a hollow space through which an IOL is passed and an outlet through which the IOL is passed from the hollow space into an eye, and a water soluble lubricity enhancing component physically secured to said hollow tube and concentrated at or near the interior wall in an amount effective to facilitate the passage of the IOL through the hollow space.

Abstract: Apparatus for inserting intraocular lenses (IOLs) into eyes comprises a tube, a rod having a distal end portion, and a tip carried by the distal end portion. The tip is softer than the distal end portion of the rod. Methods for inserting an IOL into an eye using such apparatus are within the scope of the present invention.

Abstract: Intraocular lenses include an optic adapted to focus light toward a retina of an eye and a movement assembly coupled to the optic. The optic includes a far vision correction power for infinity reduced by a diopter power increment. The movement assembly is adapted to cooperate with the eye to move the optic bidirectionally, that is anteriorly in the eye and posteriorly in the eye, for example, from a neutral resting position in the eye, to effect positive accommodating movement of the optic and negative accommodating movement of the optic, respectively. Methods of inserting such intraocular lenses into an eye are also provided.

Abstract: An intraocular lens implantable in an eye includes an optic for placement in the capsular bag of the eye and for directing light toward the retina of the eye. The optic has a central optical axis, an anterior face, an opposing posterior face and a peripheral edge surface between the faces. The peripheral edge surface has a substantially continuous curved configuration in the direction between the faces. The intersection of the peripheral edge surface and at least one of the anterior face and the posterior face, preferably both of such faces, forms a peripheral corner located at a discontinuity between the peripheral edge surface and the intersecting face or faces. The present IOLs inhibit cell growth from the eye in front of or in back of the optic and reduce glare obtained in the eye in which the IOL is located.

Abstract: A folding device for holding and folding an IOL and adapted to allow a surgeon to select between loading the IOL into a removably attached IOL injector and between holding the IOL in a folded state for removal with a separate instrument. The folding device includes a pair of opposing sides, each having an upper surface. A plurality of retaining brackets extend upwardly from the upper surfaces of each side. The brackets are adapted for receiving and removably retaining the IOL injector. A hinge couples the sides together along a fold axis and allows the sides to retain the IOL therebetween. The hinge allows the sides to fold together from a planer position about a first fold direction when using the separate instrument and towards each other about a second fold direction when using the IOL injector.

Abstract: Apparatus for holding intraocular lenses and apparatus for holding intraocular lens injectors are provided which provide convenient and effective packaging systems for intraocular lenses and allow convenient and effective transfer of an intraocular lens to an injector in preparation for insertion of the intraocular lens into an eye.

Abstract: Apparatus for inserting intraocular lenses (IOLs) into eyes comprises a tube, a rod having a distal end portion, and a tip carried by the distal end portion. The tip is softer than the distal end portion of the rod. Methods for inserting an IOL into an eye using such apparatus are within the scope of the present invention.

Abstract: Apparatus for inserting intraocular lenses (IOLs) into eyes include a hollow tube including a material and having an interior wall defining a hollow space through which an IOL is passed and an outlet through which the IOL is passed from the hollow space into an eye, and a lubricity enhancing component physically secured to said hollow tube and concentrated at or near the interior wall in an amount effective to facilitate the passage of the IOL through the hollow space.

Abstract: A three phase control arrangement is employed after visual detection of a target at greater range than otherwise available. The first and last phases employ an optimization criterion for which errors do not vary with distance from a target; limiting the initial error and process error in an intermediate phase which controls approach trajectory to the intended docking location and yielding repeatable high accuracy docking. The three phase approach with different control criteria and control gain parameters makes feasible a docking maneuver that begins at a much greater range and potentially greater lateral separation from the destination than would otherwise be possible, while providing control of both the final location and final orientation of the vehicle. A preferred visual thresholding technique provides consistency of results over a wide range of illumination and contrast conditions while limiting the computation burden for target image acquisition and tracking.

Abstract: A folding device for holding and folding an IOL and adapted to allow a surgeon to select between loading the IOL into a removably attached IOL injector and between holding the IOL in a folded state for removal with a separate instrument. The folding device includes a pair of opposing sides, each having an upper surface. A plurality of retaining brackets extend upwardly from the upper surfaces of each side. The brackets are adapted for receiving and removably retaining the IOL injector. A hinge couples the sides together along a fold axis and allows the sides to retain the IOL therebetween. The hinge allows the sides to fold together from a planer position about a first fold direction when using the separate instrument and towards each other about a second fold direction when using the IOL injector.

Abstract: Method of making an apparatus for inserting intraocular lenses (IOLs) into eyes include a hollow tube including a material and having a plasma exposed interior wall defining a hollow space through which an IOL is passed and an outlet through which the IOL is passed from the hollow space into an eye, and a lubricity enhancing component physically secured to said hollow tube and concentrated at or near the interior wall in an amount effective to facilitate the passage of the IOL through the hollow space.

Abstract: Apparatus for inserting intraocular lenses (IOLs) into eyes comprises a tube, a rod having a distal end portion, and a tip carried by the distal end portion. The tip is softer than the distal end portion of the rod. Methods for inserting an IOL into an eye using such apparatus are within the scope of the present invention.

Abstract: Apparatus for inserting intraocular lenses (IOLs) into eyes comprises a tube, a rod having a distal end portion, and a tip carried by the distal end portion. The tip is softer than the distal end portion of the rod. Methods for inserting an IOL into an eye using such apparatus are within the scope of the present invention.

Abstract: Apparatus for insertion of intraocular lenses into the eye are disclosed. In one embodiment, the apparatus comprises a loading chamber and an injection portion. The loading chamber has a proximal end and a distally extending opening. The loading chamber defines a first lumen and is adapted to receive an intraocular lens in an unfolded state at the distally extending opening and to fold the intraocular lens and maintain the intraocular lens folded as the intraocular lens is placed in the first lumen. The injection portion defines a second lumen aligned with the first lumen and is adapted to receive the folded intraocular lens from the first lumen in the second lumen. The injection portion has an open distal end through which the folded intraocular lens from the second lumen passes to be inserted into an eye.