Patents by Inventor Daniel G. Genov

Daniel G. Genov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same
    Patent number: 11939333
    Abstract: Solid forms of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphic forms, cocrystals, and amorphous forms thereof, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: January 18, 2022
    Date of Patent: March 26, 2024
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Louis Grenier, Andre Lescarbeau, Praveen Sharma, Daniel G. Genov
  • SOLID FORMS OF ISOQUINOLINONES, AND PROCESS OF MAKING, COMPOSITION COMPRISING, AND METHODS OF USING THE SAME
    Publication number: 20220135576
    Abstract: Solid forms of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphic forms, cocrystals, and amorphous forms thereof, and pharmaceutical compositions thereof.
    Type: Application
    Filed: January 18, 2022
    Publication date: May 5, 2022
    Inventors: Louis Grenier, Andre Lescarbeau, Praveen Sharma, Daniel G. Genov
  • Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same
    Patent number: 11247995
    Abstract: Solid forms of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphic forms, cocrystals, and amorphous forms thereof, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: February 15, 2022
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Louis Grenier, Andre Lescarbeau, Praveen Sharma, Daniel G. Genov
  • SOLID FORMS OF ISOQUINOLINONES, AND PROCESS OF MAKING, COMPOSITION COMPRISING, AND METHODS OF USING THE SAME
    Publication number: 20190185477
    Abstract: Solid forms of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphic forms, cocrystals, and amorphous forms thereof, and pharmaceutical compositions thereof.
    Type: Application
    Filed: November 20, 2018
    Publication date: June 20, 2019
    Inventors: Louis Grenier, Andre Lescarbeau, Praveen Sharma, Daniel G. Genov
  • Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same
    Patent number: 10160761
    Abstract: Solid forms of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphic forms, cocrystals, and amorphous forms thereof, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: December 25, 2018
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Louis Grenier, Andre Lescarbeau, Praveen Sharma, Daniel G. Genov
  • Transfer hydrogenation of cyclopamine analogs
    Patent number: 9879025
    Abstract: Provided herein is a process for the transfer-hydrogenation of ketone analogs of members of the jervine type of Veratrum alkaloids, such as cyclopamine. Also provided herein are novel ruthenium transfer-hydrogenation catalysts.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: January 30, 2018
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Daniel G. Genov, Brian C. Austad, Brian H. White
  • SOLID FORMS OF ISOQUINOLINONES, AND PROCESS OF MAKING, COMPOSITION COMPRISING, AND METHODS OF USING THE SAME
    Publication number: 20170088553
    Abstract: Solid forms of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphic forms, cocrystals, and amorphous forms thereof, and pharmaceutical compositions thereof.
    Type: Application
    Filed: September 13, 2016
    Publication date: March 30, 2017
    Inventors: Louis Grenier, Andre Lescarbeau, Praveen Sharma, Daniel G. Genov
  • TRANSFER HYDROGENATION OF CYCLOPAMINE ANALOGS
    Publication number: 20170029433
    Abstract: Provided herein is a process for the transfer-hydrogenation of ketone analogs of members of the jervine type of Veratrum alkaloids, such as cyclopamine. Also provided herein are novel ruthenium transfer-hydrogenation catalysts.
    Type: Application
    Filed: June 23, 2016
    Publication date: February 2, 2017
    Inventors: Daniel G. Genov, Brian C. Austad, Brian H. White
  • Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
    Patent number: 9481667
    Abstract: Solid forms of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. Also provided herein are processes for preparing compounds, solid forms thereof, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: November 1, 2016
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Daniel G. Genov, Louis Grenier, Andrew B. Hague, Alexander Redvers Eberlin, Ludovic Sylvain Marc Renou, Susana Del Rio Gancedo
  • Transfer hydrogenation of cyclopamine analogs
    Patent number: 9394313
    Abstract: Provided herein is a process for the transfer-hydrogenation of ketone analogs of members of the jervine type of Veratrum alkaloids, such as cyclopamine. Also provided herein are novel ruthenium transfer-hydrogenation catalysts.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: July 19, 2016
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Daniel G. Genov, Brian C. Austad, Brian H. White
  • Transfer hydrogenation of cyclopamine analogs
    Patent number: 9376447
    Abstract: Provided herein is a process for the transfer-hydrogenation of ketone analogs of members of the jervine type of Veratrum alkaloids, such as cyclopamine. Also provided herein are novel ruthenium transfer-hydrogenation catalysts.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: June 28, 2016
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Daniel G. Genov, Brian C. Austad, Brian H. White
  • SALTS AND SOLID FORMS OF ISOQUINOLINONES AND COMPOSITION COMPRISING AND METHODS OF USING THE SAME
    Publication number: 20160024051
    Abstract: Solid forms of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. Also provided herein are processes for preparing compounds, solid forms thereof, and pharmaceutical compositions thereof.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 28, 2016
    Inventors: Daniel G. GENOV, Louis GRENIER, Andrew B. HAGUE, Alexander Redvers EBERLIN, Ludovic Sylvain Marc RENOU, Susana DEL RIO GANCEDO
  • SALTS AND SOLID FORMS OF ISOQUINOLINONES AND COMPOSITION COMPRISING AND METHODS OF USING THE SAME
    Publication number: 20140275135
    Abstract: Solid forms of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. Also provided herein are processes for preparing compounds, solid forms thereof, and pharmaceutical compositions thereof.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: Infinity Pharmaceuticals, Inc.
    Inventors: Daniel G. GENOV, Louis GRENIER, Andrew B. HAGUE, Alexander Redvers EBERLIN, Ludovic Sylvain Marc RENOU, Susana DEL RIO GANCEDO
  • Transfer Hydrogenation of Cyclopamine Analogs
    Publication number: 20120065400
    Abstract: Provided herein is a process for the transfer-hydrogenation of ketone analogs of members of the jervine type of Veratrum alkaloids, such as cyclopamine. Also provided herein are novel ruthenium transfer-hydrogenation catalysts.
    Type: Application
    Filed: September 14, 2011
    Publication date: March 15, 2012
    Applicant: INFINITY PHARMACEUTICALS, INC.
    Inventors: Daniel G. Genov, Brian C. Austad, Brian H. White
  • Transfer Hydrogenation of Cyclopamine Analogs
    Publication number: 20120065399
    Abstract: Provided herein is a process for the transfer-hydrogenation of ketone analogs of members of the jervine type of Veratrum alkaloids, such as cyclopamine. Also provided herein are novel ruthenium transfer-hydrogenation catalysts.
    Type: Application
    Filed: September 14, 2011
    Publication date: March 15, 2012
    Applicant: INFINITY PHARMACEUTICALS, INC.
    Inventors: Daniel G. Genov, Brian C. Austad, Brian H. White