Patents by Inventor Daniel G. Jay

Daniel G. Jay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of extracellular HSP90
    Patent number: 9068987
    Abstract: The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention relates to the use of molecules inhibiting extracellular Hsp90 function for the manufacture of a medicament for the treatment or prevention of invasion and/or metastatic potential of cancer cells.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: June 30, 2015
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: Daniel G. Jay, Brenda K. Eustace, Takashi Sakurai
  • INHIBITORS OF EXTRACELLULAR HSP90
    Publication number: 20140079720
    Abstract: The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention relates to the use of molecules inhibiting extracellular Hsp90 function for the manufacture of a medicament for the treatment or prevention of invasion and/or metastatic potential of cancer cells.
    Type: Application
    Filed: November 19, 2013
    Publication date: March 20, 2014
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: Daniel G. Jay, Brenda K. Eustace, Takashi Sakurai
  • NEUROPILIN-1 INHIBITORS
    Publication number: 20120058117
    Abstract: The present invention relates to molecules interfering with the function of neuropilin-1 in the context of angiogenesis and the treatment of cancer. Molecules, polypeptides, antibodies, compositions and methods are provided that are useful for reducing, inhibiting or treating angiogenesis, the invasion of blood vessels into tumors, and/or the invasion or the metastatic potential of specific tumor cells. Additionally, a method is provided that allows identifying molecules, which interfere with the functionality of neuropilin-1. Furthermore, a method is provided that allows determining whether a naturally occurring tumor cell depends on functional neuropilin-1 for its invasiveness and/or metastatic potential.
    Type: Application
    Filed: June 22, 2011
    Publication date: March 8, 2012
    Applicants: MEDAREX, INC., TUFTS UNIVERSITY
    Inventors: Christine Margarete UNGER, Gerald BESTE, Carolin ZEHETMEIER, Blanca LAIN, Claudia TORELLA, Jens NIEWÖHNER, Daniel G. JAY, Brenda K. EUSTACE, Roland KNAUER, Kristian Hobold JENSEN
  • INHIBITORS OF EXTRACELLULAR HSP90
    Publication number: 20110150881
    Abstract: The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention relates to the use of molecules inhibiting extracellular Hsp90 function for the manufacture of a medicament for the treatment or prevention of invasion and/or metastatic potential of cancer cells.
    Type: Application
    Filed: November 22, 2010
    Publication date: June 23, 2011
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: Daniel G. Jay, Brenda K. Eustace, Takashi Sakurai
  • Inhibitors of extracellular Hsp90
    Patent number: 7959915
    Abstract: The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention relates to the use of molecules inhibiting extracellular Hsp90 function for the manufacture of a medicament for the treatment or prevention of invasion and/or metastatic potential of cancer cells.
    Type: Grant
    Filed: September 12, 2005
    Date of Patent: June 14, 2011
    Assignee: Tufts University
    Inventors: Daniel G. Jay, Brenda K. Eustace, Takashi Sakurai
  • MODULATION OF THE POLIOVIRUS RECEPTOR FUNCTION
    Publication number: 20090215175
    Abstract: The present invention relates to the identification, the isolation and the use of molecules interfering with the function (s) mediated by the poliovirus receptor (PVR) on cells. The molecules can be used for the treatment of cells having a metastatic potential, metastasis and cancer. Further methods are provided that are useful for identifying and isolating molecules, which have the capacity to modulate PVR mediated adhesion or invasion potential of cells.
    Type: Application
    Filed: November 12, 2008
    Publication date: August 27, 2009
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: Christine Margarete UNGER, Gerald BESTE, Carolin ZEHETMEIER, Blanca LAIN, Claudia TORELLA, Daniel G. JAY, Brenda K. EUSTACE, Kevin Ernest SLOAN
  • Method for identifying biological binding molecules and apparatus for carrying out the method
    Publication number: 20030165842
    Abstract: The invention relates to a method for identifying the function of a ligand L using chromophore-assisted laser inactivation (CALI), characterized by the stages:
    Type: Application
    Filed: July 18, 2001
    Publication date: September 4, 2003
    Inventors: Jocelyn Ng, Daniel G. Jay, Liming Ge, Leodevico L. llag
  • Laser inactivation of inhibitory molecules in central nervous system myelin
    Patent number: 6479053
    Abstract: Methods for specifically inactivating myelin proteins which inhibit nerve regeneration are described. These methods are useful to promote axon regeneration.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: November 12, 2002
    Assignee: President and Fellows of Harvard College
    Inventor: Daniel G. Jay