Patents by Inventor Daniel G. Moro

Daniel G. Moro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110123621
    Abstract: The present invention relates to a method of forming shape-retentive and shape-conforming aggregate wound dressings and biomaterials composed of gel nanoparticles and wound or bodily fluid in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a dry powder of gel nanoparticles to a wound site in which the nanoparticles absorb some of the blood or wound exudate and coalesce in situ into the claimed shape-retentive aggregate dressing. The method also comprises introducing the dry nanoparticle powder in or on a wet bodily tissue in vivo to form the claimed shape-retentive biomaterial. In addition, the method also comprises incorporating biomedical agents to produce medicated aggregate dressings or biomaterials for a variety of medical applications. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel nanoparticles.
    Type: Application
    Filed: October 8, 2010
    Publication date: May 26, 2011
    Inventors: John St. John, Daniel G. Moro
  • Patent number: 7910135
    Abstract: The present invention relates to a method of forming shape-retentive and shape-conforming aggregate wound dressings and biomaterials composed of gel nanoparticles and wound or bodily fluid in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a dry powder of gel nanoparticles to a wound site in which the nanoparticles absorb some of the blood or wound exudate and coalesce in situ into the claimed shape-retentive aggregate dressing. The method also comprises introducing the dry nanoparticle powder in or on a wet bodily tissue in vivo to form the claimed shape-retentive biomaterial. In addition, the method also comprises incorporating biomedical agents to produce medicated aggregate dressings or biomaterials for a variety of medical applications. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel nanoparticles.
    Type: Grant
    Filed: October 13, 2006
    Date of Patent: March 22, 2011
    Assignee: ULURU Inc.
    Inventors: John St. John, Daniel G. Moro
  • Patent number: 7811605
    Abstract: The present invention relates to a method of forming shape-retentive aggregates of gel particles in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a suspension of gel particles in a polar liquid at a selected concentration, wherein the gel particles have an absolute zeta potential, into a medium in which the absolute zeta potential of the gel particles is decreased, resulting in the gel particles coalescing into the claimed shape-retentive aggregate. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel particles.
    Type: Grant
    Filed: October 6, 2004
    Date of Patent: October 12, 2010
    Assignee: ULURU Inc.
    Inventors: Daniel G. Moro, John V. St. John, Kevin F. Shannon, Bill C. Ponder
  • Publication number: 20090196936
    Abstract: The present invention relates to a method of forming shape-retentive and shape-conforming aggregate wound dressings and biomaterials composed of gel nanoparticles and wound or bodily fluid in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a dry powder of gel nanoparticles to a wound site in which the nanoparticles absorb some of the blood or wound exudate and coalesce in situ into the claimed shape-retentive aggregate dressing. The method also comprises introducing the dry nanoparticle powder in or on a wet bodily tissue in vivo to form the claimed shape-retentive biomaterial. In addition, the method also comprises incorporating biomedical agents to produce medicated aggregate dressings or biomaterials for a variety of medical applications. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel nanoparticles.
    Type: Application
    Filed: October 13, 2006
    Publication date: August 6, 2009
    Inventors: John ST. John, Daniel G. Moro
  • Publication number: 20080166409
    Abstract: The present invention is related to hydrogel particles and aggregates formed therefrom having characteristics including, without limitation, shape-retentiveness, elasticity, controllable pore sizes and controllable degradation rates that render them useful for a wide variety of applications including, without limitation, the controlled release of biologically active substances, in vivo medical devices, tissue growth scaffolding and tissue replacement.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 10, 2008
    Inventors: John V. St. John, Daniel G. Moro, Bill C. Ponder
  • Patent number: 7351430
    Abstract: The present invention is related to hydrogel particles and aggregates formed therefrom having characteristics including, without limitation, shape-retentiveness, elasticity, controllable pore sizes and controllable degradation rates that render them useful for a wide variety of applications including, without limitation, the controlled release of biologically active substances, in vivo medical devices, tissue growth scaffolding and tissue replacement.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: April 1, 2008
    Assignee: ULURU Inc.
    Inventors: John V. St. John, Daniel G. Moro, Bill C. Ponder
  • Publication number: 20040086548
    Abstract: The present invention is related to hydrogel particles and aggregates formed therefrom having characteristics including, without limitation, shape-retentiveness, elasticity, controllable pore sizes and controllable degradation rates that render them useful for a wide variety of applications including, without limitation, the controlled release of biologically active substances, in vivo medical devices, tissue growth scaffolding and tissue replacement.
    Type: Application
    Filed: November 6, 2002
    Publication date: May 6, 2004
    Inventors: John V. St. John, Daniel G. Moro, Bill C. Ponder
  • Publication number: 20040062724
    Abstract: A thin, flexible, bilayer or multi-layer film which when applied to teeth surfaces adheres and delivers an active compound to the underlying surface and erodes at a predetermined rate. The amount of time that the active agent remains in contact with the teeth surfaces is controlled by the composition of backing layer of the composite film. This erosion or residence time can be regulated one half hour to three hours, depending upon the desired therapeutic or cosmetic application.
    Type: Application
    Filed: May 23, 2003
    Publication date: April 1, 2004
    Inventors: Daniel G. Moro, Ernest Howard Callahan, David P. Nowotnik
  • Publication number: 20030138490
    Abstract: Disclosed is a new class of nanostructured polymeric materials comprising polymer gel nanoparticles that are covalently bonded through functional groups on the surfaces of neighboring particles. These nanoparticles may be prepared as suspensions in an aqueous or, non-aqueous environment. These gels have two unique and different structural networks; the primary network comprises crosslinked polymer chains in each individual particle, while the secondary network is a system of crosslinked nanoparticles. Particular polymer gel nanoparticle network compositions disclosed herein may function as carriers for controlled delivery of pharmaceuticals or other chemical agents, gel sensors and other commercial applications.
    Type: Application
    Filed: August 9, 2002
    Publication date: July 24, 2003
    Inventors: Zhibing Hu, Xihua Lu, Jun Gao, Bill C. Ponder, John St. John, Daniel G. Moro
  • Patent number: 6585997
    Abstract: The present invention relates to a layered pharmaceutical delivery device for the administration of pharmaceuticals or other active compounds to mucosal surfaces. The device may also be used by itself without the incorporation of a therapeutic. The device of the present invention consists of a water-soluble adhesive layer, a non-adhesive, bioerodable backing layer and one or more pharmaceuticals if desired in either or both layers. Upon application, the device adheres to the mucosal surface, providing protection to the treatment site and localized drug delivery. The “Residence Time”, the length of time the device remains on the mucosal surface before complete erosion, can be easily regulated by modifications of the backing layer.
    Type: Grant
    Filed: August 16, 2001
    Date of Patent: July 1, 2003
    Assignee: Access Pharmaceuticals, Inc.
    Inventors: Daniel G. Moro, Howard Callahan, David Nowotnik
  • Publication number: 20030044446
    Abstract: The present invention relates to a layered pharmaceutical delivery device for the administration of pharmaceuticals or other active compounds to mucosal surfaces. The device may also be used by itself without the incorporation of a therapeutic. The device of the present invention consists of a water-soluble adhesive layer, a non-adhesive, bioerodable backing layer and one or more pharmaceuticals if desired in either or both layers. Upon application, the device adheres to the mucosal surface, providing protection to the treatment site and localized drug delivery. The “Residence Time”, the length of time the device remains on the mucosal surface before complete erosion, can be easily regulated by modifications of the backing layer.
    Type: Application
    Filed: August 16, 2001
    Publication date: March 6, 2003
    Applicant: MUCOADHESIVE ERODIBLE DRUG DELIVERY DEVICE FOR CONTROLLED ADMN. OF PHARMACEUTICALS & OTHER ACTI
    Inventors: Daniel G. Moro, Howard Callahan, David Nowotnik
  • Patent number: 5468811
    Abstract: Hydrophilic composite polymer articles are provided which comprise at least one hydrophilic polymer in a powder form and one or more liquid components of which at least one is hydrophilic and which can be polymerized with said hydrophilic polymer. This composition is produced from a homogeneously mixed paste which can be molded or cast into a desired shape which will subsequently set. The resulting article has a shape-retaining, non-tacky flexible consistency which allows the shape to be further modified, if necessary.Such object can be then cured by any of the conventional curing methods to retain its shape permanently. The final properties of the composite can be tailored to suit the final application by using fillers or modifiers. In the medical field, such articles can be utilized as a sustained release devices as they can be loaded with the desired therapeutic drugs. These articles can be made non-toxic and biocompatible and used as prosthetic devices.
    Type: Grant
    Filed: August 24, 1994
    Date of Patent: November 21, 1995
    Assignee: National Patent Development Corporation
    Inventors: Daniel G. Moro, Samuel H. Ronel, Petr Kuzma
  • Patent number: 5292515
    Abstract: A method of preparing a hydrophilic plastic cartridge by centrifugally cang polymerizable hydrophilic material in a rotating polymerization tube whose longitudinal axis is maintained parallel to the ground. The speed of rotation causes radial outward displacement of the polymerizable material which upon assuming a predetermined shape within the rotating tube is then polymerized to the predetermined solid configuration. The resulting plastic cartridge is characterized by smooth, unscored internal and external cylindrical surfaces. The cartridges are used as a rate-limiting membrane in drug delivery devices. Sterilized kits containing a disposable needle/syringe or trocar-like instrument and the drug delivery device are used for subcutaneous implantation of the device in an animal body.
    Type: Grant
    Filed: March 31, 1993
    Date of Patent: March 8, 1994
    Assignee: Hydro Med Sciences, a Division of National Patent Development Corporation
    Inventors: Daniel G. Moro, Petr Kuzma, Harry Quandt
  • Patent number: 5266325
    Abstract: A method is provided for the preparation of homogeneous copolymers having a redetermined equilibrium water content (EWC) value formed by the addition polymerization of a mixture of ethylenically unsaturated monomer A and ethylenically unsaturated monomer B, for example, 2-hydroxyethyl methacrylate and hydroxypropyl methacrylate. The method requires determining the EWC values of the hydrogel homopolymer of hydrophilic monomer A (homopolymer A) and the hydrogel homopolymer of hydrophilic monomer B (homopolymer B); determining the relationship of the EWC values of the homogeneous copolymers AB versus the chemical composition of said copolymers AB; selecting the targeted EWC value and determining the chemical composition of copolymer AB having the targeted EWC value; forming a polymerizable mixture of monomer A and monomer B in amounts sufficient to yield copolymer AB having the targeted EWC value; and effect the polymerization reaction to yield copolymer AB characterized by the targeted EWC value.
    Type: Grant
    Filed: December 3, 1990
    Date of Patent: November 30, 1993
    Assignee: Hydro Med Science Division of National Patent Development Corp.
    Inventors: Petr Kuzma, Daniel G. Moro, Harry Quandt
  • Patent number: 5177154
    Abstract: A water compatible terpolymer for sealing and coating building materials which protects surfaces from environmental staining agents. The terpolymer is created by polymerizing a HEMA:SMA co-polymer with another monomer which contains either free acid or base groups. The resultant terpolymer is water solution after neutralization. Water is then added to bring the solvent level to 40% maximum and the solids level to 8%.
    Type: Grant
    Filed: April 30, 1991
    Date of Patent: January 5, 1993
    Assignee: National Patent Development Corp.
    Inventor: Daniel G. Moro
  • Patent number: 5045266
    Abstract: An acoustically sealed earmold for a hearing aid insertable into the ear of individuals with impaired hearing can be prepared in situ employing the hydrophilic composite polymer materials described herein. Such composite materials include at least one hydrophilic polymer in a powder form and one or more liquid components of which at least one is hydrophilic and which can be polymerized with said hydrophilic polymer. The resulting earmold has a shape-retaining, non-tacky flexible consistency which allows it to be shaped further and also to be modified to accommodate a receiver adapter or external receiver. The earmold can then be cured by any of the conventional curing methods to retain its shape permanently. This method enables an audiologist to fit the earmold and evaluate the hearing aid in a single office visit.
    Type: Grant
    Filed: November 2, 1989
    Date of Patent: September 3, 1991
    Assignee: National Patent Development Corporation
    Inventors: Daniel G. Moro, Samuel H. Ronel, Petr Kuzma
  • Patent number: 4272518
    Abstract: There is provided a composition and a process of treating a wound, especially burned tissue surface comprising applying to the wound a settable, non-toxic paste comprising a particulate, hydrophilic, water-swellable polymer and an inert, water-miscible organic liquid having a boiling point above about 120.degree. C. capable of forming a paste therewith, said paste having a setting time of up to an hour and a working time sufficient to apply to the paste to the burned tissue surface, the polymer of said paste in set condition being water-insoluble.
    Type: Grant
    Filed: July 10, 1979
    Date of Patent: June 9, 1981
    Inventors: Daniel G. Moro, Gary A. Griffin, Mark J. D'Andrea