Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Abstract: A centrifuge apparatus for separating whole blood into its serum and cell components. The device consists of a small centrifuge cup having a movable bottom wall formed by an upwardly movable piston. The cup is surrounded by a three-tiered ring-shaped container with the two upper tiers each containing a plurality of pockets. The centrifuge cup is spun at a high speed and the whole blood sample in the cup is separated, with excess sample expelled into the lowest tier. The multi-pocketed container is also spun as a centrifuge coaxially with the cup but at a lower speed. The bottom wall piston of the cup and the container are movable vertically relative to the cup by respective cams operated by a common timer-controlled motor.