Patents by Inventor Daniel G. Yansura
Daniel G. Yansura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230357445Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.Type: ApplicationFiled: April 7, 2023Publication date: November 9, 2023Applicant: Genentech, Inc.Inventors: Justin SCHEER, Christoph SPIESS, Daniel G. YANSURA
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Publication number: 20210171662Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.Type: ApplicationFiled: September 18, 2020Publication date: June 10, 2021Inventors: Justin SCHEER, Christoph SPIESS, Daniel G. YANSURA
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Publication number: 20190185584Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.Type: ApplicationFiled: July 25, 2018Publication date: June 20, 2019Inventors: Justin SCHEER, Christoph SPIESS, Daniel G. YANSURA
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Publication number: 20180282431Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.Type: ApplicationFiled: October 27, 2017Publication date: October 4, 2018Inventors: Justin SCHEER, Christoph SPIESS, Daniel G. YANSURA
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Patent number: 9637557Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.Type: GrantFiled: April 22, 2011Date of Patent: May 2, 2017Assignee: Genentech, Inc.Inventors: Justin Scheer, Christoph Spiess, Daniel G. Yansura
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Publication number: 20160222115Abstract: The invention provides methods and compositions comprising a novel stabilized monovalent antibody fragment.Type: ApplicationFiled: April 15, 2016Publication date: August 4, 2016Applicant: Genentech, Inc.Inventors: Arthur Jyh-Yen Huang, Ralph H. Schwall, Daniel G. Yansura
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Publication number: 20160207995Abstract: The invention provides anti-IL-4 antibodies and bispecific antibodies and methods of using the same.Type: ApplicationFiled: September 18, 2015Publication date: July 21, 2016Applicant: GENENTECH, INC.Inventors: Daniel G. Yansura, Nancy Y. Chiang, Mark S. Dennis, Michael Dillon, Germaine G. Fuh, Gerald R. Nakamura, Christoph Spiess, Lawren C. Wu, Yin Zhang
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Publication number: 20150266953Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.Type: ApplicationFiled: December 23, 2014Publication date: September 24, 2015Applicant: GENENTECH, INC.Inventors: Jian CHEN, Ellen FILVAROFF, Sherman FONG, Dorothy FRENCH, Audrey GODDARD, Paul J. GODOWSKI, J. Christopher GRIMALDI, Austin L. GUMEY, Kenneth J. HILLAN, Sarah G. HYMOWITZ, Hanzhong LI, James Pan ZTUBICOKE, Melissa A. STAROVASNIK, Daniel TUMAS, Menno VAN LOOKEREN, Richard VANDLEN, Colin K. WATANABE, P. Mickey WILLIAMS, William I. WOOD, Daniel G. YANSURA
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Publication number: 20150141283Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.Type: ApplicationFiled: September 17, 2014Publication date: May 21, 2015Applicant: GENENTECH, INC.Inventors: Jian CHEN, Ellen FILVAROFF, Sherman FONG, Dorothy FRENCH, Audrey GODDARD, Paul J. GODOWSKI, J. Christopher GRIMALDI, Austin L. GURNEY, Kenneth J. HILIAN, Sarah G. HYMOWITZ, Hanzhong LI, Melissa A. STAROVASNIK, Daniel TUMAS, Menno VAN LOOKEREN, Richard VANDLEN, Colin K. WATANABE, P. Mickey WILLIAMS, William I. WOOD, Daniel G. YANSURA, James PAN
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Publication number: 20140205593Abstract: The invention provides methods and compositions comprising a novel stabilized monovalent antibody fragment.Type: ApplicationFiled: April 15, 2013Publication date: July 24, 2014Applicant: Genentech, Inc.Inventors: Arthur Jyh-Yen Huang, Ralph H. Schwall, Daniel G. Yansura
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Publication number: 20130064827Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.Type: ApplicationFiled: August 23, 2012Publication date: March 14, 2013Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Dorothy French, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gumey, Kenneth J. Hillan, Sarah G. Hymowitz, Hanzhong Li, James Pan, Melissa A. Starovasnik, Daniel Tumas, Menno Van Lookeren, Richard Vandlen, Colin K. Watanabe, P. Mickey Williams, William I. Wood, Daniel G. Yansura
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Patent number: 8273703Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.Type: GrantFiled: September 29, 2006Date of Patent: September 25, 2012Assignee: Genentech, Inc.Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Dorothy French, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gumey, Kenneth J. Hillan, Sarah G. Hymowitz, Hanzhong Li, James Pan, Melissa A. Starovasnik, Daniel Tumas, Menno Van Lookeren, Richard Vandlen, Colin K. Watanabe, P. Mickey Williams, William I. Wood, Daniel G. Yansura
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Publication number: 20120064073Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.Type: ApplicationFiled: October 10, 2011Publication date: March 15, 2012Inventors: Jian Chen, Ellen Fllvaroff, Sherman Fong, Dorothy French, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Sarah G. Hymowitz, Hanzhong Li, James Pan, Melissa A. Starovasnik, Daniel Tumas, Menno Van Lookeren, Richard Vandlen, Colin K. Watanabe, P. Mickey Williams, William I. Wood, Daniel G. Yansura
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Publication number: 20120058909Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.Type: ApplicationFiled: October 10, 2011Publication date: March 8, 2012Inventors: Jian Chen, Elleri Filvaroff, Sherman Fong, Dorothy French, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hilian, Sarah G. Hymowitz, Hanzhong Li, James Pan, Melissa A. Starovasnik, Daniel Tumas, Menno Van Lookeren, Richard Vandlen, Colin K. Watanabe, P. Mickey Williams, William I. Wood, Daniel G. Yansura
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Publication number: 20110287009Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.Type: ApplicationFiled: April 22, 2011Publication date: November 24, 2011Applicant: Genentech, Inc.Inventors: Justin Scheer, Christoph Spiess, Daniel G. Yansura
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Patent number: 8034342Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.Type: GrantFiled: August 28, 2009Date of Patent: October 11, 2011Assignee: Genentech, Inc.Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Dorothy French, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Sarah G. Hymowitz, Hanzhong Li, James Pan, Melissa A. Starovasnik, Daniel Tumas, Menno Van Lookeren, Richard Vandlen, Colin K. Watanabe, P. Mickey Williams, William I. Wood, Daniel G. Yansura
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Publication number: 20110200596Abstract: The invention provides methods and compositions comprising a novel stabilized monovalent antibody fragment.Type: ApplicationFiled: March 10, 2011Publication date: August 18, 2011Applicant: Genentech, Inc.Inventors: Arthur Jyh-Yen Huang, Ralph H. Schwall, Daniel G. Yansura
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Publication number: 20100028343Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.Type: ApplicationFiled: August 28, 2009Publication date: February 4, 2010Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Dorothy French, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Sarah G. Hymowitz, Hanzhong Li, James Pan, Melissa A. Starovasnik, Daniel Tumas, Menno Van Lookeren, Richard Vandlen, Colin K. Watanabe, P. Mickey Williams, William I. Wood, Daniel G. Yansura
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Publication number: 20080160021Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.Type: ApplicationFiled: December 3, 2007Publication date: July 3, 2008Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Dorothy French, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Sarah G. Hymowitz, Hanzhong Li, James Pan, Melissa A. Starovasnik, Daniel Tumas, Menno Van Lookeren, Richard Vandlen, Colin K. Watanabe, P. Mickey Williams, William J. Wood, Daniel G. Yansura
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Patent number: 7029876Abstract: Vectors for producing polypeptides heterologous to prokaryotes are described comprising, along with the polypeptide-encoding nucleic acid, anti-termination nucleic acid that inhibits intragenic transcription termination with a non-lambda promoter therefor and/or nucleic acid encoding a GreA or GreB protein and a promoter therefor. Also described are processes for producing a heterologous polypeptide in prokaryotic host cells utilizing such elements to improve the quality and/or quantity of heterologous polypeptide produced.Type: GrantFiled: February 22, 2002Date of Patent: April 18, 2006Assignee: Genentech, Inc.Inventors: Eriks Sasha Paegle, Dorothea Reilly, Daniel G. Yansura