Patents by Inventor Daniel Getman

Daniel Getman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alpha-and beta-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Publication number: 20050267171
    Abstract: ?- and ?-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: April 21, 2005
    Publication date: December 1, 2005
    Applicant: G.D. Searle & Co.
    Inventors: Michael Vazquez, Richard Mueller, John Talley, Daniel Getman, Gary DeCrescenzo, John Freskos, Deborah Bertenshaw, Robert Heintz
  • Alpha-and beta-amino acid hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors
    Publication number: 20050267214
    Abstract: Certain Alpha- and Beta-amino acid hydroxyethylamino sulfamic acid derivatives represented by the following formula are useful as retroviral protease inhibitors:
    Type: Application
    Filed: June 28, 2005
    Publication date: December 1, 2005
    Applicant: G.D. Searle & Co.
    Inventors: Michael Vazquez, Richard Mueller, John Talley, Daniel Getman, Gary DeCrescenzo, Eric Sun
  • Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
    Publication number: 20050227926
    Abstract: Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Application
    Filed: January 18, 2005
    Publication date: October 13, 2005
    Applicant: G.D. Searle & Co.
    Inventors: Daniel Getman, Gary DeCrescenzo, John Freskos, Michael Vazquez, James Sikorski, Balekudru Devadas, Srinivasan Nagarajan, David Brown, Joseph McDonald
  • Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
    Publication number: 20050171366
    Abstract: A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
    Type: Application
    Filed: October 13, 2004
    Publication date: August 4, 2005
    Applicant: G.D. Searle & Co.
    Inventors: John Ng, Claire Przybyla, Richard Mueller, Michael Vazquez, Daniel Getman
  • Cyclic sulfone containing retroviral protease inhibitors
    Publication number: 20050119257
    Abstract: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
    Type: Application
    Filed: September 2, 2004
    Publication date: June 2, 2005
    Applicants: G.D. Searle & Co., Pharmacia Corporation (Monsanto Company)
    Inventors: Deborah Bertenshaw, Daniel Getman, Robert Heintz, John Talley, Kathryn Reed, Robert Chrusciel, Michael Clare
  • Sulfonyl aryl or heteroaryl hydroxamic acid compounds
    Publication number: 20050075374
    Abstract: A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.
    Type: Application
    Filed: June 14, 2004
    Publication date: April 7, 2005
    Inventors: Louis Bedell, Joseph McDonald, Thomas Barta, Daniel Becker, Shashidhar Rao, John Freskos, Brent Mischke, Daniel Getman, Gary DeCrescenzo, Clara Villamil
  • Cyclic sulfone containing retroviral protease inhibitors
    Patent number: 6875790
    Abstract: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
    Type: Grant
    Filed: February 20, 2003
    Date of Patent: April 5, 2005
    Assignees: G. D. Searle & Co., Pharmacia Corporation (Monsanto Corporation)
    Inventors: Deborah E. Bertenshaw, Daniel Getman, Robert M. Heintz, John J. Talley, Kathryn L. Reed, Robert Alan Chrusciel, Michael Clare
  • Thiol sulfonamide metalloprotease inhibitors
    Publication number: 20050014840
    Abstract: This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfonamide inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes for the preparation of proteinase inhibitors and processes for treating pathological conditions associated with pathological matrix metalloproteinase activity related to MMP-13.
    Type: Application
    Filed: May 4, 2004
    Publication date: January 20, 2005
    Inventors: Zaheer Abbas, Gary DeCrescenzo, John Freskos, Daniel Getman, Robert Heintz, Joseph McDonald, Brent Mischke
  • Retroviral protease inhibitors
    Publication number: 20050004230
    Abstract: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: March 5, 2004
    Publication date: January 6, 2005
    Applicant: Monsanto Company (now named Pharmacia Corporation, which is a wholly owned subsidiary of Pfizer, Inc
    Inventors: John Talley, Daniel Getman, Gary DeCrescenzo, Kathryn Reed, Ko-Chung Lin, John Freskos, Michael Clare, Donald Rogier, Robert Heintz, Michael Vazquez, Richard Mueller
  • Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Publication number: 20050004043
    Abstract: Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: February 24, 2004
    Publication date: January 6, 2005
    Applicant: G.D. Searle & Co.
    Inventors: Michael Vazquez, Richard Mueller, John Talley, Daniel Getman, Gary DeCrescenzo, John Freskos
  • Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Publication number: 20040267022
    Abstract: Sulfonamide-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: January 2, 2004
    Publication date: December 30, 2004
    Applicant: G. D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
  • Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent number: 6743929
    Abstract: Sulfonamide-containing hydroxyethylamine compounds are effecive as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: September 6, 2000
    Date of Patent: June 1, 2004
    Assignee: G. D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
  • Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent number: 6727282
    Abstract: Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: April 27, 2004
    Assignee: G.D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
  • Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inyhibitors
    Publication number: 20030220508
    Abstract: Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: September 9, 2002
    Publication date: November 27, 2003
    Applicant: G.D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
  • Cyclic sulfone containing retroviral protease inhibitors
    Patent number: 6552203
    Abstract: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
    Type: Grant
    Filed: October 11, 2001
    Date of Patent: April 22, 2003
    Assignee: Monsanto Company
    Inventors: Deborah E. Bertenshaw, Daniel Getman, Robert M. Heintz, John J. Talley, Kathryn L. Reed, Robert Alan Chrusciel, Michael Clare
  • &agr;- and &bgr;-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent number: 6534493
    Abstract: &agr;- and &bgr;-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: October 24, 2000
    Date of Patent: March 18, 2003
    Assignee: G.D. Searle
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
  • &agr; and &bgr;-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent number: 6472407
    Abstract: &agr;- and &bgr;-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: October 29, 2002
    Assignee: G.D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
  • Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent number: 6469207
    Abstract: Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: June 20, 2001
    Date of Patent: October 22, 2002
    Assignee: G. D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
  • Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Publication number: 20020137942
    Abstract: Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: June 20, 2001
    Publication date: September 26, 2002
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
  • Cyclic sulfone containing retroviral protease inhibitors
    Publication number: 20020107264
    Abstract: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
    Type: Application
    Filed: October 11, 2001
    Publication date: August 8, 2002
    Inventors: Deborah E. Bertenshaw, Daniel Getman, Robert M. Heintz, John J. Talley, Kathryn L. Reed, Robert Alan Chrusciel, Michael Clare