Patents by Inventor Daniel Getts

Daniel Getts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for genomic integration
    Patent number: 12599678
    Abstract: Methods and composition for modulating a target genome and stable integration of a transgene of interest into the genome of a cell are disclosed.
    Type: Grant
    Filed: May 5, 2023
    Date of Patent: April 14, 2026
    Assignee: CREATE Medicines, Inc.
    Inventors: Daniel Getts, Yuxiao Wang, Namita Bisaria, Inna Shcherbakova, Socheata Ly
  • Covalent polymer-antigen conjugated particles
    Patent number: 12502436
    Abstract: The present invention provides compositions comprising tolerizing immune modified particles (TIMPs) and methods for using and making said TIMPs. In particular, carrier polymer is covalently conjugated with antigenic peptide before particle formation, which allows for exquisite control of particle size and antigen encapsulation (e.g., for use in eliciting induction of immunological tolerance).
    Type: Grant
    Filed: October 24, 2022
    Date of Patent: December 23, 2025
    Assignees: COUR PHARMACEUTICALS DEVELOPMENT COMPANY INC., REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Ryan Pearson, Daniel Getts, John Puisis, James Herrmann, Lonnie D. Shea
  • ENGINEERED CHIMERIC FUSION PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20250276064
    Abstract: Compositions and methods for making and using engineered cells, such as, engineered myeloid cells that express a chimeric fusion protein that has a binding domain capable to binding surface molecules on target cells such as diseased cells.
    Type: Application
    Filed: March 20, 2025
    Publication date: September 4, 2025
    Inventors: Daniel Getts, Yuxiao Wang
  • COMPOSITIONS FOR CELL-SPECIFIC EXPRESSION AND USES THEREOF
    Publication number: 20250249099
    Abstract: Compositions and methods for making and using engineered NK cells, T cells and B cells that express a chimeric antigen receptor.
    Type: Application
    Filed: February 28, 2025
    Publication date: August 7, 2025
    Inventors: Daniel GETTS, Yuxiao Wang, Neha Diwanji
  • METHODS AND COMPOSITIONS FOR GENOMIC INTEGRATION
    Publication number: 20250250584
    Abstract: Methods and composition for modulating a target genome and stable integration of a transgene of interest into the genome of a cell are disclosed.
    Type: Application
    Filed: April 23, 2025
    Publication date: August 7, 2025
    Inventors: Daniel Getts, Yuxiao Wang, Namita Bisaria, Inna Shcherbakova, Socheata Ly
  • Methods and compositions for genomic integration
    Patent number: 12319925
    Abstract: Methods and composition for modulating a target genome and stable integration of a transgene of interest into the genome of a cell are disclosed.
    Type: Grant
    Filed: January 19, 2023
    Date of Patent: June 3, 2025
    Assignee: MYELOID THERAPEUTICS, INC.
    Inventors: Daniel Getts, Yuxiao Wang, Namita Bisaria, Inna Shcherbakova, Socheata Ly
  • BINDING DOMAINS AND METHODS OF USE THEREOF
    Publication number: 20250090663
    Abstract: Compositions and methods for binding to target antigens. Compositions comprising variable heavy chain domains with binding specificity to CD70, GPC3, IL13Ralpha2 and Cadherin CDH17 antigens.
    Type: Application
    Filed: September 13, 2024
    Publication date: March 20, 2025
    Inventors: Daniel Getts, Yuxiao Wang, Vania Emilova Ashminova, Thach Chu
  • Therapeutic cell compositions and methods of manufacturing and use thereof
    Patent number: 12252545
    Abstract: The present disclosure provides compositions and methods for making and using engineered killer phagocytic cells for immunotherapy in cancer or infection by expressing a chimeric antigen receptor having an enhanced phagocytic activity, the chimeric receptor is encoded by a recombinant nucleic acid.
    Type: Grant
    Filed: March 15, 2021
    Date of Patent: March 18, 2025
    Assignee: MYELOID THERAPEUTICS, INC.
    Inventors: Daniel Getts, Yuxiao Wang
  • ENGINEERED CHIMERIC FUSION PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20240391998
    Abstract: Compositions and methods for making and using engineered cells, such as, engineered myeloid cells that express a chimeric fusion protein that has a binding domain capable to binding surface molecules on target cells such as diseased cells.
    Type: Application
    Filed: May 24, 2024
    Publication date: November 28, 2024
    Inventors: Daniel Getts, Yuxiao Wang
  • MACROPHAGE SPECIFIC ENGAGER COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20240327482
    Abstract: Compositions and methods for making and using therapeutic agents comprising myeloid cell specific engagers, used for immunotherapy of cancer or infection.
    Type: Application
    Filed: March 8, 2024
    Publication date: October 3, 2024
    Inventors: Daniel Getts, Yuxiao Wang, Bruce McCreedy, Jr.
  • ENGINEERED CHIMERIC FUSION PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20240252630
    Abstract: Compositions and methods for making and using engineered cells, such as, engineered myeloid cells that express a chimeric fusion protein that has a binding domain capable to binding surface molecules on target cells such as diseased cells.
    Type: Application
    Filed: February 6, 2024
    Publication date: August 1, 2024
    Inventors: Daniel Getts, Yuxiao Wang, Bruce McCreedy, Jr.
  • Engineered chimeric fusion protein compositions and methods of use thereof
    Patent number: 12030938
    Abstract: Compositions and methods for making and using engineered cells, such as, engineered myeloid cells that express a chimeric fusion protein that has a binding domain capable to binding surface molecules on target cells such as diseased cells.
    Type: Grant
    Filed: January 20, 2023
    Date of Patent: July 9, 2024
    Assignee: MYELOID THERAPEUTICS, INC.
    Inventors: Daniel Getts, Yuxiao Wang
  • ENGINEERED CHIMERIC FUSION PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20240182543
    Abstract: Compositions and methods for making and using engineered myeloid cells that express a chimeric fusion protein for immunotherapy and compositions and methods for making and using engineered T cells that express a chimeric antigen receptor for immunotherapy.
    Type: Application
    Filed: November 21, 2023
    Publication date: June 6, 2024
    Inventors: Daniel GETTS, Yuxiao WANG
  • THERAPEUTIC CELL COMPOSITIONS AND METHODS FOR MANUFACTURE AND USES THEREOF
    Publication number: 20240148785
    Abstract: The present disclosure provides compositions and methods for making and using engineered killer phagocytic cells for immunotherapy in cancer or infection by expressing a chimeric antigen receptor having an enhanced phagocytic activity, the chimeric receptor is encoded by a recombinant nucleic acid.
    Type: Application
    Filed: November 2, 2023
    Publication date: May 9, 2024
    Inventors: Daniel GETTS, Patrick Mendes TAVARES
  • COMPOSITIONS AND METHODS FOR CONDITIONING PATIENTS FOR CELL THERAPY
    Publication number: 20240139241
    Abstract: Compositions and methods for therapeutic use of engineered myeloid cells are described. Methods for increasing therapeutic effectiveness of immune cells by use of an immune cell inhibitory agent prior to therapy is described. Effective use of myeloid cells in combination therapy is described.
    Type: Application
    Filed: October 23, 2023
    Publication date: May 2, 2024
    Inventors: Daniel GETTS, Bruce J. McCreedy, JR., Michele Luise Gerber, Thomas Etienne Prod’homme
  • ENGINEERED CHIMERIC FUSION PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20240139314
    Abstract: The present disclosure provides compositions and methods for making and using engineered myeloid cells for immunotherapy in cancer or infection by expressing a chimeric antigen receptor having an enhanced phagocytic activity, wherein the chimeric receptor is encoded by a recombinant nucleic acid.
    Type: Application
    Filed: October 13, 2023
    Publication date: May 2, 2024
    Inventors: Daniel GETTS, Yuxiao WANG
  • Engineered chimeric fusion protein compositions and methods of use thereof
    Patent number: 11944680
    Abstract: Compositions and methods for making and using engineered cells, such as, engineered myeloid cells that express a chimeric fusion protein that has a binding domain capable to binding surface molecules on target cells such as diseased cells.
    Type: Grant
    Filed: January 18, 2023
    Date of Patent: April 2, 2024
    Assignee: MYELOID THERAPEUTICS, INC.
    Inventors: Daniel Getts, Yuxiao Wang, Bruce McCreedy, Jr.
  • Methods and Compositions for Expression of Nucleic Acids in Cells
    Publication number: 20230374538
    Abstract: Compositions and methods for making and using engineered phagocytic cells that express a chimeric antigen receptor having an enhanced phagocytic activity for stable and durable expression are described and can be suitably used for immunotherapy in cancer or infection.
    Type: Application
    Filed: March 22, 2023
    Publication date: November 23, 2023
    Inventors: Daniel GETTS, Yuxiao WANG, Namita BISARIA, Inna SHCHERBAKOVA, William F. ROWLEY, JR.
  • METHODS AND COMPOSITIONS FOR GENOMIC INTEGRATION
    Publication number: 20230364266
    Abstract: Methods and composition for modulating a target genome and stable integration of a transgene of interest into the genome of a cell are disclosed.
    Type: Application
    Filed: May 5, 2023
    Publication date: November 16, 2023
    Inventors: Daniel GETTS, Yuxiao Wang, Namita Bisaria, Inna Shcherbakova, Socheata Ly
  • METHODS AND COMPOSITIONS FOR GENOMIC INTEGRATION
    Publication number: 20230364265
    Abstract: Methods and composition for modulating a target genome and stable integration of a transgene of interest into the genome of a cell are disclosed.
    Type: Application
    Filed: May 5, 2023
    Publication date: November 16, 2023
    Inventors: Daniel GETTS, Yuxiao Wang, Namita Bisaria, Inna Shcherbakova, Socheata Ly