Abstract: The laser micro-porator (10) for porating a biological membrane (1), comprises: a) a laser source (7) that emits a pulsed beam (4), the laser source (7) comprising a laser diode (7c); b) optics (8a,8b,8x) that modify the pulsed beam to direct a laser beam (4) of less that 1 mm width on the biological membrane (1); c) a deflector (8f) oriented to direct the laser beam (4) in various directions; d) a laser beam shaping device that reshapes the energy intensity distribution of the laser beam (4); and e) a poration controller (11) that controls the laser source (7) to create a poration consisting of a plurality of individual pores (2) in the biological membrane (1).

Abstract: A micro-porator (10) for porating a biological membrane (1), comprising: a) a controller (11) b) an initial microporation dataset (D); c) and an ablator (10a) for creating a microporation on the biological membrane (1), the controller (11) controlling the ablator (10a) based on the initial microporation dataset (D), to create the microporation as defined by the initial microporation dataset (D).

Abstract: A system for transmembrane administration of a permeant, the system comprising: a) at least one permeant (5a), b) data of at least one initial microporation dataset (D) for the at least one permeant (5a), c) and a micro-porator (10) configured to porate a biological membrane (1) as defined by the initial microporation dataset (D).

Abstract: There is disclosed a method for creating an initial permeation surface (A) in a biological membrane (1) comprising: a) creating a plurality of individual micropores (2i) in the biological membrane (1), each individual micropore (2i) having an individual permeation surface (Ai); and b) creating such a number of individual micropores (2i) and of such shapes, that the initial permeation surface (A), which is the sum of the individual permeation surfaces (Ai) of all individual micropores (2i), having a desired value. A Microporator performing the method is also disclosed.

Abstract: The laser micro-porator (10) for porating a biological membrane (1), comprises: a) a laser source (7) that emits a pulsed beam (4), the laser source (7) comprising a laser diode (7c); b) optics (8a,8b,8x) that modify the pulsed beam to direct a laser beam (4) of less that 1 mm width on the biological membrane (1); c) a deflector (8f) oriented to direct the laser beam (4) in various directions; d) a laser beam shaping device that reshapes the energy intensity distribution of the laser beam (4); and e) a poration controller (11) that controls the laser source (7) to create a poration consisting of a plurality of individual pores (2) in the biological membrane (1).