Abstract: Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.

Abstract: A method of positioning a uterine manipulator within a patient includes applying a deforming force to a colpotomizer cup of the uterine manipulator to adjust the colpotomizer cup from a nominal width configuration to a reduced width configuration, inserting the colpotomizer cup into a vaginal canal of the patient while the colpotomizer cup is in the reduced width configuration, removing the deforming force from the colpotomizer cup to allow the colpotomizer cup to expand from the reduced width configuration to the nominal width configuration, and positioning the colpotomizer cup about a cervix of the patient while the colpotomizer cup is in the nominal width configuration.

Abstract: A method of positioning a uterine manipulator within a patient includes applying a deforming force to a colpotomizer cup of the uterine manipulator to adjust the colpotomizer cup from a nominal width configuration to a reduced width configuration, inserting the colpotomizer cup into a vaginal canal of the patient while the colpotomizer cup is in the reduced width configuration, removing the deforming force from the colpotomizer cup to allow the colpotomizer cup to expand from the reduced width configuration to the nominal width configuration, and positioning the colpotomizer cup about a cervix of the patient while the colpotomizer cup is in the nominal width configuration.

Abstract: A method of adjusting a uterine manipulator includes inserting a shaft of the uterine manipulator into a cervix, moving a colpotomizer sleeve of the uterine manipulator to a predetermined position along the shaft such that the cervix is received within a colpotomizer cup attached to the colpotomizer sleeve, depressing a rotatable locking member of the colpotomizer sleeve towards the shaft, confirming that the colpotomizer sleeve is accurately located at the predetermined position by visualizing a ruler marking of a plurality of ruler markings printed along the shaft using a magnification lens of the rotatable locking member, and compressing the shaft with the rotatable locking member of the colpotomizer sleeve to lock the colpotomizer sleeve at the predetermined position.

Abstract: A method of adjusting a uterine manipulator includes inserting a shaft of the uterine manipulator into a cervix, moving a colpotomizer sleeve of the uterine manipulator to a predetermined position along the shaft such that the cervix is received within a colpotomizer cup attached to the colpotomizer sleeve, depressing a rotatable locking member of the colpotomizer sleeve towards the shaft, confirming that the colpotomizer sleeve is accurately located at the predetermined position by visualizing a ruler marking of a plurality of ruler markings printed along the shaft using a magnification lens of the rotatable locking member, and compressing the shaft with the rotatable locking member of the colpotomizer sleeve to lock the colpotomizer sleeve at the predetermined position.

Abstract: A uterine manipulator includes a shaft configured to be inserted into a cervix and a colpotomizer assembly configured to move along the shaft. The shaft includes multiple ruler markings printed along a portion of the shaft. The colpotomizer assembly includes a sleeve that includes a rotatable locking member configured to compress the shaft in a manner that locks the colpotomizer assembly in position along the shaft when the rotatable locking member is depressed against the shaft. The rotatable locking member includes a cam roller configured to compress the shaft when the rotatable locking member is depressed towards the shaft.

Abstract: A uterine manipulator includes a shaft configured to be inserted into a cervix and a colpotomizer assembly configured to move along the shaft. The shaft includes multiple ruler markings printed along a portion of the shaft. The colpotomizer assembly includes a sleeve that includes a rotatable locking member configured to compress the shaft in a manner that locks the colpotomizer assembly in position along the shaft when the rotatable locking member is depressed against the shaft. The rotatable locking member includes a cam roller configured to compress the shaft when the rotatable locking member is depressed towards the shaft.