Abstract: Systems and methods for delivering and retrieving a leadless pacemaker are described. A leadless pacemaker retrieval system includes a catheter system having a snare assembly to capture the leadless pacemaker. The catheter system includes sheaths extending distally from a shaft, and the snare assembly includes several snare legs, such as segments of snare loops, that extend from one sheath to connect to another sheath. The snare loops can have bights that connect to opposing sheaths to form a docking space between the legs of the snare loops and radially between the sheaths. The snare assembly is movable between an engaged position and a disengaged position by translating the snare legs within lumens of the corresponding sheaths. In the engaged position, the snare assembly tightens around the leadless pacemaker to allow the leadless pacemaker to be retrieved. Other embodiments are also described and claimed.

Abstract: Provided is a near memory processing (NMP) module for a centralized logging storage array, which includes one or more servers configured to host one or more allocation units assigned to a logical volume, wherein the NMP module is associated with a respective allocation unit. The NMP module is configured to return a state of the respective allocation unit in response to one or more commands received from one or more client devices. The state of the allocation unit includes a mode of the allocation unit. The mode includes one of active, uninitialized, or sealed. When the mode of the allocation unit is uninitialized, the NMP module is configured to change the mode of the respective allocation unit to active in response to receiving an append command from a client device.

Abstract: A storage array for centralized logging is provided. The storage array for centralized logging includes one or more servers and a near memory processing NMP module. The one or more servers are configured to host one or more allocation units allocated to a logical volume. The NMP module is configured for one or more allocation units, and the NMP module is configured to record and update a state of a respective allocation unit in a reserved area of the respective allocation unit. The state includes a virtual offset of the respective allocation unit within a virtual log and a range of valid data in the respective allocation unit, and the NMP module is configured to return the allocation unit state in response to a command from one of one or more client devices.

Abstract: Systems and methods for delivering and retrieving a leadless pacemaker are described. A leadless pacemaker retrieval system includes a catheter system having a snare assembly to capture the leadless pacemaker. The catheter system includes sheaths extending distally from a shaft, and the snare assembly includes several snare legs, such as segments of snare loops, that extend from one sheath to connect to another sheath. The snare loops can have bights that connect to opposing sheaths to form a docking space between the legs of the snare loops and radially between the sheaths. The snare assembly is movable between an engaged position and a disengaged position by translating the snare legs within lumens of the corresponding sheaths. In the engaged position, the snare assembly tightens around the leadless pacemaker to allow the leadless pacemaker to be retrieved. Other embodiments are also described and claimed.

Abstract: An introducer hub assembly, such as an introducer hub assembly of a leadless cardiac pacemaker, including a hemostatic seal having a cross-slit configuration, is described. The hemostatic seal can be retained between a hub cap and an introducer hub. The hemostatic seal includes a first section having first slits intersecting along a longitudinal axis of the introducer hub, and a second section having second slits intersecting along the longitudinal axis. The first slits are angularly offset relative to the second slits to reduce a likelihood that fluid will leak directly through the seal. Other embodiments are also described and claimed.

Abstract: The disclosure provides compositions and methods for modifying a target nucleic acid. In some embodiments, a composition can include a targetable nuclease, a DNA-binding protein, and a donor template comprising a homology directed repair (HDR) template and one or more DNA-binding protein target sequences. In some embodiments, a composition can include a Cas protein, one or more single guide RNAs (sgRNAs), and an anionic polymer.

Abstract: A memory controller is configured to be operatively connected to clients for shared memory access. The memory controller is configured to perform a recovery of a shared memory by determining starting point for the recovery and then replicating shared memory to target file system. The memory controller is configured to determine starting point by: generate journal of file operations, generate a snapshot of the shared memory; restore shared memory as per the snapshot to the target file system; determine last operation before snapshot in journal; and set next operation after last operation as starting point. The memory controller is further configured to replicate shared memory by replaying file operations according to journal starting with starting point. The present disclosure enables to create an initial consistent synchronization point of the shared memory with clients, which in turn ensures reliable data recovery of the shared memory in any adverse event.

Abstract: A NAS memory controller is provided that is operatively connected to one or more NAS clients for shared memory access, where each NAS client includes a clock and is operatively connected to other NAS clients of the one or more NAS clients through a low-latency communications network. The NAS memory controller is configured to transmit an indication of a stop time and a restart time to each of the one or more NAS clients, and receive a journal of file operations from each of the one or more NAS clients after the stop time arrives. The NAS memory controller is further configured to determine a status of each journal.

Abstract: In a method for data recovery in a continuous data protection system, delta values representing an exclusive disjunction between successive values of data block contents of a content fragment of a dataset at a time t(n) and a time t(n?1) for n=1 to i, where i is selected according to a predetermined data protection profile, are generated. The delta values can be used to recover a dataset to a value at the selected point in time in association with a snapshot that is selected as a starting point for recovery based on a cost analysis associated with a volume of disk activity to restore.

Abstract: Controller technology, in which data specifying a user preference relating to an environmental parameter for a property is received. Based on data collected by a monitoring system, a location of one or more users within the property is identified. Environmental condition data for the property is accessed, the environmental condition data including environmental condition data for the location of the users within the property and other unoccupied locations within the property. The environmental condition data for the property is analyzed with respect to the preference relating to the environmental parameter for the property. Based on the analysis of the environmental condition data for the property with respect to the preference relating to the environmental parameter for the property, a setting for at least one component of an HVAC system is determined. The at least one component of the HVAC system is controlled according to the determined setting.

Abstract: An introducer hub assembly, such as an introducer hub assembly of a leadless cardiac pacemaker, including a hemostatic seal having a cross-slit configuration, is described. The hemostatic seal can be retained between a hub cap and an introducer hub. The hemostatic seal includes a first section having first slits intersecting along a longitudinal axis of the introducer hub, and a second section having second slits intersecting along the longitudinal axis. The first slits are angularly offset relative to the second slits to reduce a likelihood that fluid will leak directly through the seal. Other embodiments are also described and claimed.

Abstract: Constraints may be generated in a target programming language from traces of operations specified in a source input. Operations specified in an input, such as a data structure like a Directed Acyclic Graph (DAG) or source programming language, that access data may be traced. Based on the traces, a code template may be generated in a target programming language or data structure to test the operations of the traces to determine which traces are valid in order to add a portion of code in the target programing language that allow external code to be run only on valid traces.

Abstract: Templates may be generated for exploring models with discrete random variable distributions. Models may be received at a compiler that includes a description or translates to a Directed Acyclical Graph (DAG) that represents a probabilistic model, including one or more random variables. Traces starting from the one or more random variables and leading to a node in the DAG may be generated to convert into a set of groups of traces. Individual traces may be sorted in the groups of traces according to dependencies between traces in the groups of traces and code templates generated that explore a state space of possible sample values drawn from the one or more random variables.

Abstract: Read, write, and array tracking may be performed for a tree representing a program or a portion of a program. A tree may be obtained from a compiler or an interpreter. The tree may be traversed to generate a map data structure in a single pass, constructing a chain of dependencies between results observed at each node visited as part of traversing the tree.

Abstract: A method for tracking surgical items with a system including an imaging system, a display, and one or more processors is provided. The method includes capturing a video that depicts a user handling the surgical items, and performing computational analysis of the video to detect a characteristic arm motion of the user which is indicative of the user moving the surgical item to be counted in to a surgical procedure. The method further includes, in response to each instance of the characteristic arm motion being detected, updating a count of surgical items and displaying the updated count on the display.

Abstract: Different sampling orders of random variables in a Bayesian model may be generated for Markov Chain Monte Carlo sampling techniques. Code may be received that causes a Markov Chain Monte Carlo sampling technique to be performed with respect to a Bayesian model that includes random variables representing different parameterized probability distributions and connected via edges in a Directed Acyclical Graph (DAG). Instructions may be generated to execute the code that cause the Markov Chain Monte Carlo sampling technique, the instructions including performing different orders for sampling different random variables in the DAG in different iterations of the Markov Chain Monte Carlo sampling technique.

Abstract: A transport system for delivery or retrieval of a biostimulator, such as a leadless cardiac pacemaker, is described. The biostimulator transport system includes a docking cap supported by a bearing within a bearing housing. The bearing allows relative rotation between a torque shaft connected to the docking cap and an outer catheter connected to the bearing housing. The bearing housing and the docking cap include respective bearing retainers that constrain the bearing within the bearing housing without a weld attachment. The weldless retainers of the biostimulator transport system provide a robust mechanical securement of the bearing that is not vulnerable to corrosion. Other embodiments are also described and claimed.

Abstract: The present disclosure provides collapsible medical devices that may be introduced via a delivery device into a pre-existing patent foramen ovale or trans-septal puncture hole and left in place to provide both a sealing function on the atrial wall and a septal-access function for additional procedures. The disclosed medical devices include a penetrable and re-sealable gasket material disposed in an open lumen in the medical device. This penetrable and re-sealable material allows catheters or other medical devices to pass therethough for providing additional therapy to an individual. By allowing the access point or portal to be opened by a guidewire or another medical tool, the medical devices as disclosed herein may be particularly suitable for a variety of cardiac procedures including, for example, atrial fibrillation, mitral valve replacement or repair, left atrial appendage closures, and the like.

Abstract: Described herein are methods and systems for tracking surgical items. The methods may be performed by one or more processors, and may include receiving a first count of surgical items, receiving one or more images, wherein each image is a field of view comprising one or more surgical items, determining a second count of surgical items based at least in part on the one or more received images, and providing a notification based on the comparison between the first count of surgical items and the second count of surgical items.

Abstract: The present disclosure provides collapsible medical devices that may be introduced via a delivery device into a pre-existing patent foramen ovale or trans-septal puncture hole and left in place to provide both a sealing function on the atrial wall and a septal-access function for additional procedures. The disclosed medical devices include a penetrable and re-sealable gasket material disposed in an open lumen in the medical device. This penetrable and re-sealable material allows catheters or other medical devices to pass therethough for providing additional therapy to an individual. By allowing the access point or portal to be opened by a guidewire or another medical tool, the medical devices as disclosed herein may be particularly suitable for a variety of cardiac procedures including, for example, atrial fibrillation, mitral valve replacement or repair, left atrial appendage closures, and the like.