Patents by Inventor Daniel Griffith Anderson

Daniel Griffith Anderson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220204654
    Abstract: Provided herein are new cyclodextrin-based compounds, and pharmaceutically acceptable salts, stereoisomers, and isotopically labeled derivatives thereof, which are capable of binding sugars (e.g., glucose). The compounds provided herein may be conjugated to agents or tags (e.g., therapeutic agents such as insulin) to form conjugates. In another aspect, also provided herein are pharmaceutical compositions comprising the compounds and conjugates described herein. The compounds and conjugates described herein are capable of binding glucose; therefore, provided herein are methods of sensing or detecting glucose comprising contacting glucose with the compound or conjugate. In another aspect, also provided herein are methods of treating a disease (e.g., a metabolic disorder, such as diabetes) in a subject comprising administering to the subject a compound, conjugate, or composition provided herein.
    Type: Application
    Filed: April 24, 2020
    Publication date: June 30, 2022
    Applicant: Massachusetts Institute of Technology
    Inventors: Chandrabali Bhattacharya, Robert S. Langer, Daniel Griffith Anderson, Arijit Basu
  • Publication number: 20220054642
    Abstract: The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.
    Type: Application
    Filed: November 2, 2021
    Publication date: February 24, 2022
    Applicant: Massachusetts Institute of Technology
    Inventors: Matthew J. Webber, Eric Andrew Appel, Robert S. Langer, Daniel Griffith Anderson
  • Publication number: 20210388196
    Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (?-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.
    Type: Application
    Filed: June 15, 2021
    Publication date: December 16, 2021
    Applicants: Massachusetts Institute of Technology, Politecnico di Milano
    Inventors: Umberto Capasso Palmiero, James C. Kaczmarek, Daniel Griffith Anderson, Davide Moscatelli
  • Patent number: 11191841
    Abstract: The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: December 7, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Matthew J. Webber, Eric Andrew Appel, Robert S. Langer, Daniel Griffith Anderson
  • Publication number: 20210260195
    Abstract: The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as “conjugated lipomers” or “lipomers”) containing one or more groups of the formula (iii): wherein R3 and R4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.
    Type: Application
    Filed: December 15, 2020
    Publication date: August 26, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: James E. Dahlman, Avraham D. Schroeder, Daniel Griffith Anderson, Robert S. Langer, Christopher G. Levins
  • Patent number: 11041069
    Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (?-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: June 22, 2021
    Assignees: Massachusetts Institute of Technology, Politecnico di Milano
    Inventors: Umberto Capasso Palmiero, James C. Kaczmarek, Daniel Griffith Anderson, Davide Moscatelli
  • Publication number: 20210101875
    Abstract: Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
    Type: Application
    Filed: October 14, 2020
    Publication date: April 8, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: Kerry Peter Mahon, Kevin Thomas Love, Christopher G. Levins, Kathryn Ann Whitehead, Robert S. Langer, Daniel Griffith Anderson
  • Patent number: 10933139
    Abstract: The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as “conjugated lipomers” or “lipomers”) containing one or more groups of the formula (iii): wherein R3 and R4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: March 2, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: James E. Dahlman, Avraham D. Schroeder, Daniel Griffith Anderson, Robert S. Langer, Christopher G. Levins
  • Patent number: 10844028
    Abstract: Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: November 24, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Kerry Peter Mahon, Kevin Thomas Love, Christopher G. Levins, Kathryn Ann Whitehead, Robert S. Langer, Daniel Griffith Anderson
  • Publication number: 20200353099
    Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
    Type: Application
    Filed: May 20, 2020
    Publication date: November 12, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
  • Publication number: 20200330501
    Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R?, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.
    Type: Application
    Filed: May 5, 2020
    Publication date: October 22, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Yizhou Dong, Kevin Love, Robert S. Langer, Daniel Griffith Anderson, Delai Chen, Yi Chen, Arturo Jose Vegas, Akinleye C. Alabi, Yunlong Zhang
  • Patent number: 10736966
    Abstract: The present disclosure provides brush-poly(glycoamidoamine)-lipids (PGALs) (e.g., polymers of any one of Formulae (I)-(IV)) and methods of preparing the PGALs. A described PGAL may include poly(glycoamidoamine)-derived moieties (e.g., such as which may assist the PGAL and/or a complex of the PGAL and an agent to pass through cell membranes or be taken up by cells. Also provided are compositions including a described PGAL and an agent (e.g., polynucleotide, small molecule, peptide, or protein).
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: August 11, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Yizhou Dong, Joseph R. Dorkin, Robert S. Langer, Daniel Griffith Anderson
  • Patent number: 10695444
    Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: June 30, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
  • Patent number: 10682374
    Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R?, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: June 16, 2020
    Assignee: Massachusetts Intstitute of Technology
    Inventors: Yizhou Dong, Kevin Thomas Love, Robert S. Langer, Daniel Griffith Anderson, Delai Chen, Yi Chen, Arturo Jose Vegas, Akinleye C. Alabi, Yunlong Zhang
  • Patent number: 10683379
    Abstract: Described herein are polymers, polymeric gels, or a composition thereof, for drug delivery. The polymers, which include boronic-acid containing moieties (e.g., and polyol-containing moieties (e.g., are prepared by free-radical polymerization and can self-assemble into polymeric gels such as hydrogels. Also provided are methods or preparing the polymers, kits involving the polymers and/or polymeric gels or a composition thereof, for use as materials or delivery applications of an agent to a subject.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: June 16, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Eric Andrew Appel, Yizhou Dong, Robert S. Langer, Benjamin C. Tang, Omid Veiseh, Weiheng Wang, Matthew J. Webber, Kun Xue
  • Publication number: 20200172663
    Abstract: The present disclosure relates to improvements in the selection and formulation of PBAE polymers using a design of experiment approach, in which statistical methods are used to limit possible experimental conditions. The present disclosure relates to improved PBAE polymers and formulations.
    Type: Application
    Filed: October 25, 2019
    Publication date: June 4, 2020
    Inventors: James C. Kaczmarek, Daniel Griffith Anderson, Luke Hyunsik Rhym, Kevin John Kauffman, Asha Kumari Patel
  • Publication number: 20200109121
    Abstract: Provided herein are lipidoid compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, solvates, hydrates, polymorphs, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive lipidoid compounds, compositions, or formulations for treating and/or preventing diseases (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, metabolic disorder, long-term medical condition, inflammatory disease, autoinflammatory disease, liver disease, lung disease, spleen disease, familial amyloid neuropathy, cardiovascular disease, viral infection, infectious disease, fibrotic condition, or autoimmune disease) in a subject, methods for synthesizing the compounds described herein, and compounds described herein synthesized by the synthetic methods described herein.
    Type: Application
    Filed: August 30, 2019
    Publication date: April 9, 2020
    Inventors: Lei Miao, Linxian Li, Daniel Griffith Anderson, Yuxuan Huang
  • Publication number: 20190240349
    Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
    Type: Application
    Filed: February 6, 2019
    Publication date: August 8, 2019
    Inventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
  • Publication number: 20190194390
    Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize amino-polyesters (APEs). The APEs are shown to be effective biodegradable carriers for drug delivery applications.
    Type: Application
    Filed: November 2, 2018
    Publication date: June 27, 2019
    Inventors: Umberto Capasso Palmiero, Piotr S. Kowalski, Davide Moscatelli, Daniel Griffith Anderson
  • Publication number: 20190194444
    Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (?-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.
    Type: Application
    Filed: November 2, 2018
    Publication date: June 27, 2019
    Inventors: Umberto Capasso Palmiero, James C. Kaczmarek, Daniel Griffith Anderson, Davide Moscatelli