Patents by Inventor Daniel GRIFFITHS
Daniel GRIFFITHS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115143Abstract: A system and method for promoting and safeguarding the wellbeing of patients in relation to a fluid injection may obtain patient data; determine, based on the patient data, an initial risk prediction for a patient for a fluid injection to be administered to the patient, the initial risk prediction including a probability that the patient experiences at least one adverse event in response to the fluid injection; provide, to a user device, before the fluid injection is administered to the patient, the initial risk prediction; determine, after the fluid injection is started, sensor data associated with the patient; determine, based on the sensor data determined after the fluid injection is started, a current risk prediction including a probability that the patient experiences the at least one adverse event in response to the fluid injection; and provide, to the user device, the current risk prediction.Type: ApplicationFiled: December 20, 2023Publication date: April 11, 2024Inventors: Johannes Anton Thüring, Arthur Uber, III, David Griffiths, Michael McDermott, Charles Lang, Linda Van Roosmalen, Barry Skirble, Adam Czibur, Daniel Moore, Vincenzo Caruso, Brandon Clarke
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Patent number: 11946598Abstract: Methods, systems, and devices for ultra or extreme-high vacuum are described. Such systems may comprise a vacuum chamber, a target within the vacuum chamber, two or more overlapping radiation shields arranged within an inner vacuum space of a vacuum chamber, and surrounding at least a portion of the target, a first and a second cooling element unit thermally coupled to a first and second radiation shield of the two or more overlapping radiation shields, wherein the first unit is configured to reduce the first radiation shield's temperature to at least <100K, and the second unit is configured to reduce the second radiation shield's temperature to at least <25K, and a third cooling element unit coupled to the target and isolated from the first and second radiation shield, wherein the third cooling element unit is configured to reduce the target's temperature to at least <4K.Type: GrantFiled: September 12, 2019Date of Patent: April 2, 2024Assignee: The Regents of of the University of Colorado, a body corporateInventors: Daniel Dessau, Justin Griffith
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Patent number: 11939321Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.Type: GrantFiled: April 7, 2021Date of Patent: March 26, 2024Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Valerio Berdini, Ildiko Maria Buck, James Edward Harvey Day, Charlotte Mary Griffiths-Jones, Thomas Daniel Heightman, Steven Howard, Christopher William Murray, David Norton, Marc O'Reilly, Alison Jo-Anne Woolford, Michael Liam Cooke, David Cousin, Stuart Thomas Onions, Jonathan Martin Shannon, John Paul Watts
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Publication number: 20240046220Abstract: A customer experience interface that facilitates provision of veterinary care is described. The customer experience interface may interact with practice resources such as practice management software or systems to generate appointment reminders and provide such reminders to pet owners. The customer experience interface may utilize suggestion models to generate sets of suggestions for a specific visit, such as tests, vaccinations, etc. Owners may be able to evaluate, select, and/or schedule services and products via a user interface provided by the customer experience interface. Owner may be able to evaluate pricing and review research or information such as instructional videos, consumer reviews, and/or other appropriate data. A visit plan may be generated and visit management may allow feedback to be received from practitioners and owners during a visit.Type: ApplicationFiled: August 8, 2022Publication date: February 8, 2024Applicant: Innovative Veterinary PracticesInventors: Marthina Greer, Daniel Griffiths
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Publication number: 20240018763Abstract: A riser bar assembly is provided for use in an ablutionary setting. An adjustable riser bar has a telescopic arrangement, and includes a first bar element, a second bar element translatable relative to the first bar element along a length of the first bar element, and a collet configured such that relative positions of the first bar element and the second bar element can be fixed by tightening the collet.Type: ApplicationFiled: July 10, 2023Publication date: January 18, 2024Inventors: Ben Lea, Daniel Griffiths, David Pixton
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Publication number: 20240018760Abstract: A fluid flow control valve assembly is provided, and includes a fluid flow control valve which includes a first flow control member having one or more flow channels, and a second flow control member adjacent to the first flow control member. The second flow control member moves relative to the first flow control member. A first valve actuator causes movement of the second flow control member relative to the first flow control member. An operating member connects to the first valve actuator. The operating member moves in a linear direction and the operating member on the first valve actuator moves the second flow control member. Movement of the second flow control member adjusts the position of the second flow control member relative to the one or more flow channels in the first flow control member such that a flow rate through the fluid flow control valve may change.Type: ApplicationFiled: July 10, 2023Publication date: January 18, 2024Inventors: Ben Lea, Daniel Griffiths, Oliver Jones
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Publication number: 20230338577Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.Type: ApplicationFiled: May 2, 2023Publication date: October 26, 2023Applicant: Massachusetts Institute of TechnologyInventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
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Publication number: 20230305590Abstract: A computer-implemented data processing method to improve information quality in data sequences by attenuating noise in the data sequences, the method including: receiving input data sequences, having a plurality of elements, from one or more sensors, each of the elements having at least one dimensional component; performing a spectral analysis on the dimensional component of each of the elements, independently, to estimate a signal profile of the input data sequences; estimating a noise profile of the input data sequences using calibration data associated with the sensor; dynamically calculating a time-constant for a noise attenuation filter, and adapting the time-constant over time, for each one of the elements in the input data sequences, based on the relationship between the noise profile and the signal profile; applying the noise attenuation filter for each one of the elements to each one of the elements, respectively, to filter the input data sequences to derive filtered data sequences; and outputting thType: ApplicationFiled: March 11, 2021Publication date: September 28, 2023Inventors: Russell Brinkworth, Anthony Finn, Daniel Griffiths, Phillip Stanley Martin Skelton
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Publication number: 20230257353Abstract: Provided herein are lipidoid compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, solvates, hydrates, polymorphs, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive lipidoid compounds, compositions, or formulations for treating and/or preventing diseases (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, metabolic disorder, long-term medical condition, inflammatory disease, autoinflammatory disease, liver disease, lung disease, spleen disease, familial amyloid neuropathy, cardiovascular disease, viral infection, infectious disease, fibrotic condition, or autoimmune disease) in a subject, methods for synthesizing the compounds described herein, and compounds described herein synthesized by the synthetic methods described herein.Type: ApplicationFiled: July 28, 2022Publication date: August 17, 2023Applicant: Massachusetts Institute of TechnologyInventors: Lei Miao, Linxian Li, Daniel Griffith Anderson, Yuxuan Huang
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Patent number: 11696953Abstract: Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.Type: GrantFiled: September 7, 2022Date of Patent: July 11, 2023Assignee: Massachusetts Institute of TechnologyInventors: Daniel Griffith Anderson, Kevin John Kauffman, James C. Kaczmarek, Asha Kumari Patel
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Publication number: 20230212288Abstract: The invention relates to the field of immunology and biotechnology, and also to the creation of novel effective high-molecular compounds having therapeutic properties. Variants of amino acid sequences of complementarity-determining regions (CDR) of antigen-binding fragments of a protein molecule specific to human cell CD3 receptors are proposed. The proposed CDR can be used for engineering various antigen-binding molecules, one of the essential function of which is a specific interaction with CD3-bearing cells. Bispecific molecules that specifically bind to human cell CD3 and CD19 receptors were engineered by means of the inclusion of said CDR in the composition of an antibody-like molecule intrinsically binding to the CD19 receptor.Type: ApplicationFiled: August 20, 2020Publication date: July 6, 2023Inventors: Aleksandr Aleksandrovich PISKUNOV, Svetlana Georgievna ABBASOVA, Anton Nikolaevich MOROZOV, Aleksandr Mikhailovich SHUSTER, Peter SLAVNY, Daniel GRIFFITHS, Izabela KACZYNSKA, John MCCAFFERTY, Michael DYSON
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Patent number: 11679165Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.Type: GrantFiled: May 20, 2020Date of Patent: June 20, 2023Assignee: Massachusetts Institute of TechnologyInventors: Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
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Publication number: 20230183168Abstract: Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of polynucleotides, such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, liver disease, spleen disease, lung disease, painful condition, psychiatric disorder, musculoskeletal disease, a metabolic disorder, inflammatory disease, or autoimmune disease).Type: ApplicationFiled: December 13, 2022Publication date: June 15, 2023Applicant: Massachusetts Institute of TechnologyInventors: Daniel Griffith Anderson, Luke Hyunsik Rhym, Allen Jiang, Jacob Witten, Idris Raji
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Publication number: 20230124955Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R?, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.Type: ApplicationFiled: August 23, 2022Publication date: April 20, 2023Applicant: Massachusetts Institute of TechnologyInventors: Yizhou Dong, Kevin Thomas Love, Robert S. Langer, Daniel Griffith Anderson, Delai Chen, Yi Chen, Arturo Jose Vegas, Akinleye C. Alabi, Yunlong Zhang
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Patent number: 11608412Abstract: The present disclosure relates to improvements in the selection and formulation of PBAE polymers using a design of experiment approach, in which statistical methods are used to limit possible experimental conditions. The present disclosure relates to improved PBAE polymers and formulations.Type: GrantFiled: October 25, 2019Date of Patent: March 21, 2023Assignee: Massachusetts Institute of TechnologyInventors: James C. Kaczmarek, Daniel Griffith Anderson, Luke Hyunsik Rhym, Kevin John Kauffman, Asha Kumari Patel
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Publication number: 20230061974Abstract: Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.Type: ApplicationFiled: September 7, 2022Publication date: March 2, 2023Applicant: Massachusetts Institute of TechnologyInventors: Daniel Griffith Anderson, Kevin John Kauffman, James C. Kaczmarek, Asha Kumari Patel
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Patent number: 11464860Abstract: Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.Type: GrantFiled: October 25, 2018Date of Patent: October 11, 2022Assignee: Massachusetts Institute of TechnologyInventors: Daniel Griffith Anderson, Kevin John Kauffman, James C. Kaczmarek, Asha Kumari Patel
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Publication number: 20220320407Abstract: An apparatus is provided for generating an electrical current from a temperature differential in an ablutionary fitting. A heat transfer plate includes a projection directly contacting water carried in a first region of the fitting. A thermoelectric module includes one or more thermoelectric elements thermally coupled between the heat transfer plate and a housing of the ablutionary fitting in a second region of the ablutionary fitting. The thermoelectric elements generate electricity from a temperature differential between water carried in the first and second regions of the ablutionary fitting.Type: ApplicationFiled: June 23, 2022Publication date: October 6, 2022Inventors: Daniel GRIFFITHS, Benjamin LEA, Mitchell Connor HOBBS
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Patent number: 11459304Abstract: Provided herein are lipidoid compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, solvates, hydrates, polymorphs, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive lipidoid compounds, compositions, or formulations for treating and/or preventing diseases (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, metabolic disorder, long-term medical condition, inflammatory disease, autoinflammatory disease, liver disease, lung disease, spleen disease, familial amyloid neuropathy, cardiovascular disease, viral infection, infectious disease, fibrotic condition, or autoimmune disease) in a subject, methods for synthesizing the compounds described herein, and compounds described herein synthesized by the synthetic methods described herein.Type: GrantFiled: August 30, 2019Date of Patent: October 4, 2022Assignee: Massachusetts Institute of TechnologyInventors: Lei Miao, Linxian Li, Daniel Griffith Anderson, Yuxuan Huang
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Patent number: 11458158Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R?, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.Type: GrantFiled: May 5, 2020Date of Patent: October 4, 2022Assignee: Massachusetts Institute of TechnologyInventors: Yizhou Dong, Kevin Thomas Love, Robert S. Langer, Daniel Griffith Anderson, Delai Chen, Yi Chen, Arturo Jose Vegas, Akinleye C. Alabi, Yunlong Zhang