Patents by Inventor Daniel Grun

Daniel Grun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating resistant cancers
    Patent number: 11246856
    Abstract: Provided herein is a method for reducing resistance in an individual having a drug resistant cancer, for example, a BRAF inhibitor resistant cancer. A Hippo signaling pathway inhibitor such as a Yes-associated protein 1 (YAP1) inhibitor, a Transcriptional Coactivator with PDZ-binding motif (TAZ) inhibitor, a Transcription enhancer domain (TEAD) inhibitor or a combination of these is administered. Also provided is a method of treating BRAF inhibitor resistance in an individual with a BRAF inhibitor resistant cancer, for example, malignant melanoma, with a Hippo signaling pathway inhibitor, such as Verteporfin, and a BRAF inhibitor.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: February 15, 2022
    Assignee: University of Maryland, Baltimore
    Inventors: Richard L. Eckert, Matthew Fisher, Daniel Grun, Gautam Adhikary, Wen Xu
  • Methods of Treating Resistant Cancers
    Publication number: 20200147047
    Abstract: Provided herein is a method for reducing resistance in an individual having a drug resistant cancer, for example, a BRAF inhibitor resistant cancer. A Hippo signaling pathway inhibitor such as a Yes-associated protein 1 (YAP1) inhibitor, a Transcriptional Coactivator with PDZ-binding motif (TAZ) inhibitor, a Transcription enhancer domain (TEAD) inhibitor or a combination of these is administered. Also provided is a method of treating BRAF inhibitor resistance in an individual with a BRAF inhibitor resistant cancer, for example, malignant melanoma, with a Hippo signaling pathway inhibitor, such as Verteporfin, and a BRAF inhibitor.
    Type: Application
    Filed: May 18, 2018
    Publication date: May 14, 2020
    Applicant: University of Baltimore, Maryland
    Inventors: Richard L. Eckert, Matthew Fisher, Daniel Grun, Gautam Adhikary, Wen Xu